A father's IgE-mediated contact urticaria from mother's milk

Mäkinen-Kiljunen, Soili; Plosila, Mikko

doi:10.1016/j.jaci.2003.10.060

Cited by 17 publications

(12 citation statements)

References 7 publications

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“…Despite this, a significant sequence homology between other bovine and human milk proteins has led to the suggestion that cross-reactivity between conserved regions of bovine and human casein may exist [47,48]. Indeed, the first case of IgE-mediated allergy to endogenous human milk protein described a young father who showed contact urticaria upon exposure to breast milk, but not cow's milk, had specific IgE antibodies to human but not bovine ALA [49]. Schulmeister et al [50] found IgE antibodies to human milk in more than 80% of the tested cow's milkallergic patients.…”

Section: Allergy To Other Mammalian Milkmentioning

confidence: 99%

Mammalian milk allergy: clinical suspicion, cross-reactivities and diagnosis

Järvinen

Chatchatee

2009

Current Opinion in Allergy &Amp; Clinical Immunology

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Section: Allergy To Other Mammalian Milkmentioning

confidence: 99%

Mammalian milk allergy: clinical suspicion, cross-reactivities and diagnosis

Järvinen

Chatchatee

2009

Current Opinion in Allergy &Amp; Clinical Immunology

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“…The demographic and serologic characterization of the milk-allergic patients (Table 1: #2-21) and a nonallergic control individual (Table 1: #1) is displayed in Table 1. Patient #11 from France is different from a previously described patient [18].…”

Section: Patients' Sera Biological Materialsmentioning

confidence: 83%

“…Several earlier studies reported that milk-allergic patients also show IgE reactivity to human milk antigens [15][16][17] and there is evidence that IgE reactivity to human milk may be of biological relevance [18]. We have analysed the presence of IgE antibodies to human milk antigens in children and adults suffering from clinically relevant allergy to milk and milk products from cows and other animals.…”

Section: Discussionmentioning

confidence: 99%

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Sensitization to human milk

Schulmeister

Swoboda

Quirce

et al. 2007

Clin Experimental Allergy

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“…Similarly, based on the homology between certain cow’s milk and human milk proteins, previous research has suggested that cross-reactivity could exist [16–19]. Clinical reactivity to human milk proteins was demonstrated in a case report describing an IgE-mediated allergic reaction in a male to human milk, but not cow’s milk, which was found to be due to specific IgE antibodies to human, but not bovine ALA [20]. This case raises the possibility of a primary sensitization to human milk proteins.…”

Section: Discussionmentioning

confidence: 99%

Presence of functional, autoreactive human milk‐specific IgE in infants with cow's milk allergy

Järvinen

Geller

Bencharitiwong

et al. 2011

Clin Experimental Allergy

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Summary Background Occasionally, exclusively breastfed infants with cow’s milk allergy (CMA) remain symptomatic despite strict maternal milk avoidance. Objective To determine whether or not persistence of symptoms could be due to sensitization against endogenous human milk proteins with a high degree of similarity to bovine allergens. Methods Ten peptides representing known bovine milk IgE-binding epitopes [α-lactalbumin (ALA), β- and κ-casein] and the corresponding, highly homologous human milk peptides were labelled with sera from 15 breastfed infants with CMA, aged 3 weeks to 12 months, and peptide (epitope)-specific IgE antibodies were assessed. Nine of the 15 breastfed infants became asymptomatic during strict maternal avoidance of milk and other major food allergens; six infants remained symptomatic until weaned. Ten older children, aged 5–15 years, with CMA were also assessed. The functional capacity of specific IgE antibodies was assessed by measuring β-hexosaminidase release from rat basophilic leukaemia cells passively sensitized and stimulated with human and bovine ALA. Results A minimum of one human milk peptide was recognized by IgE antibodies from 9 of 15 (60%) milk-allergic infants, and the majority of older children with CMA. Genuine sensitization to human milk peptides in the absence of IgE to bovine milk was occasionally seen. There was a trend towards specific IgE being detected to more human milk peptides in those infants who did not respond to the maternal milk elimination diet than in those who did (P = 0.099). Functional IgE antibody to human ALA was only detected in infants not responding to the maternal diet. Conclusions and Clinical Relevance Endogenous human milk epitopes are recognized by specific IgE from the majority of infants and children with CMA. Such autoreactive, human milk-specific IgE antibodies appear to have functional properties in vitro. Their role in provoking allergic symptoms in infants exclusively breastfed by mothers strictly avoiding dietary milk remains unclear.

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A father's IgE-mediated contact urticaria from mother's milk

Cited by 17 publications

References 7 publications

Mammalian milk allergy: clinical suspicion, cross-reactivities and diagnosis

Mammalian milk allergy: clinical suspicion, cross-reactivities and diagnosis

Sensitization to human milk

Presence of functional, autoreactive human milk‐specific IgE in infants with cow's milk allergy

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