The problems discussed in the present paper are well-known both from the theoretical (numerical) and experimental point of view. The novelty of our approach depends on the application of hybrid experimental methods and a comparison of their effectiveness in the description of complicated fatigue problems arising in the analysis of the behavior of laminated panels with open holes and subjected to tensile loading. Three experimental methods were used: infrared thermography (passive), structural health monitoring (active), and digital image correlation. The experimental investigations were supplemented by the finite element description of the problem dealing mainly with the static behavior, monitoring the development and final fracture of composites. The considerations concern laminated panels oriented at ±45 • with different types of holes, i.e., vertical elliptical, horizontal elliptical, and circular.