A Fatty Acid Glycoside from a Marine-Derived Fungus Isolated from Mangrove Plant Scyphiphora hydrophyllacea

Zeng, Yan‐Bo; Wang, Hui; Zuo, Wei; Zheng, Bo; Tao, Yang; Dai, Hao‐Fu; Mei, Wen‐Li

doi:10.3390/md10030598

Cited by 30 publications

(19 citation statements)

References 11 publications

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“…e antibacterial activity of GERM CLEAN (Shanxin, Chengdu, Sichuan, China) on S. mutans was preliminarily tested using the filter paper disc agar diffusion method introduced elsewhere with minor modification [44][45][46][47]. Briefly, 100 μl of mid-exponential phase UA159 suspension was spread on fresh nutrient BHI agar medium plates and dried at room temperature for 5 min.…”

Section: E Filter Paper Disk Agar Diffusion Methodmentioning

confidence: 99%

Antimicrobial Effect of a Peptide Containing Novel Oral Spray on Streptococcus mutans

Xiong

Chen

et al. 2020

BioMed Research International

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Objective. To investigate the antibacterial effect of a novel antimicrobial peptide containing oral spray GERM CLEAN on Streptococcus mutans (S. mutans) in vitro and further explore the related mechanisms at phenotypic and transcriptional levels. Methods. The disk diffusion method was used to preliminarily appraise the antimicrobial effect of GERM CLEAN. The minimal inhibitory concentration (MIC) of GREM CLEAN towards S. mutans was determined by the broth dilution method. S. mutans virulence-related phenotypic assays including initial adhesive assay, pH drop, exopolysaccharides (EPS), and biofilm formation measurements and quantitative real-time PCR (qRT-PCR) were further applied to detect the inhibitory mechanisms of GREM CLEAN at 1/2MIC. Results. The diameter (10.18 ± 1.744 mm) of inhibition zones formed by GERM CLEAN preliminarily indicated its inhibitory effect on the major cariogenic bacteria S. mutans. The minimal inhibitory concentration of GERM CLEAN on S. mutans was 100% mass fraction (the stock solution). The study of the antibacterial mechanism showed that GERM CLEAN had a certain inhibitory effect on the initial adhesion, acid production, extracellular polysaccharides (EPS) production, and biofilm formation of S. mutans. GERM CLEAN disturbed S. mutans biofilm physiology mainly through destruction of biofilm architecture and suppression of bacterial growth. The results of qRT-PCR further confirmed that the expression levels of EPS and lactic acid generation genes including gtfB, gtfC, gtfD, and ldh were significantly repressed by treating with GERM CLEAN, and this was consistent with our phenotypic results. Conclusion. The novel antimicrobial peptide containing oral spray GERM CLEAN has an anti-Streptococcus mutans effect and the inhibitory property may be due to suppression of the virulence factors of S. mutans including adhesive, acidogenicity, EPS, and biofilm formation.

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Section: E Filter Paper Disk Agar Diffusion Methodmentioning

confidence: 99%

Antimicrobial Effect of a Peptide Containing Novel Oral Spray on Streptococcus mutans

Xiong

Chen

et al. 2020

BioMed Research International

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“…(unidentied mangrove, South China Sea coast) was the source of the eremophilane sesquiterpenes 399-401 328 and the known fungal metabolite 07H239-A. 329 A fatty acid glucoside 402 with moderate inhibitory properties against S. aureus and MRSA was obtained from an unidentied endophytic fungus (mangrove leaves Scyphiphora hydrophyllacea, Wenchang, Hainan, China), 330 while investigation of an uniden-tied endophytic fungus (mangrove leaves Avicennia marina, Oman) yielded farinomaleins C-E 403-405 and an isoindoline congener 406, 331 in addition to the known farinomalein B. 332…”

Section: Fungi From Mangrovesmentioning

confidence: 99%

Marine natural products

et al. 2014

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This review covers the literature published in 2012 for marine natural products, with 1035 citations (673 for the period January to December 2012) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1241 for 2012), together with the relevant biological activities, source organisms and country of origin. Biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

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“…ZJ-2008004 and exhibited two Gram-positive bacteria, S. albus and B. subtilis (MIC, 5 and 2.5 μM, respectively) [ 41 ]. New fatty acid glycoside 116 was isolated from Scyphiphora hydrophyllacea A1 and showed inhibitory effects on S. aureus and MRSA (IZ, 3.8 and 4.7 at 500 μg/disk, respectively) [ 86 ].…”

Section: New Antibacterial and Antifungal Compounds From Marine Fumentioning

confidence: 99%

Antibacterial and Antifungal Compounds from Marine Fungi

et al. 2015

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This paper reviews 116 new compounds with antifungal or antibacterial activities as well as 169 other known antimicrobial compounds, with a specific focus on January 2010 through March 2015. Furthermore, the phylogeny of the fungi producing these antibacterial or antifungal compounds was analyzed. The new methods used to isolate marine fungi that possess antibacterial or antifungal activities as well as the relationship between structure and activity are shown in this review.

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A Fatty Acid Glycoside from a Marine-Derived Fungus Isolated from Mangrove Plant Scyphiphora hydrophyllacea

Cited by 30 publications

References 11 publications

Antimicrobial Effect of a Peptide Containing Novel Oral Spray on Streptococcus mutans

Antimicrobial Effect of a Peptide Containing Novel Oral Spray on Streptococcus mutans

Marine natural products

Antibacterial and Antifungal Compounds from Marine Fungi

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