A fatty acid-rich fraction of an endolichenic fungus Phoma sp. suppresses immune checkpoint markers via AhR/ARNT and ESR1

Varlı, Mücahit; Ngo, Men Thi; Kim, Seong–Min; Taş, İsa; Zhou, Rui; Gamage, Chathurika D. B.; Pulat, Sultan; Park, So‐Yeon; Sesal, Nüzhet Cenk; Hur, Jae‐Seoun; Kang, Kyo Bin; Kim, Hangun

doi:10.1016/j.heliyon.2023.e19185

Cited by 4 publications

(3 citation statements)

References 57 publications

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“…Moreover, in 2023, Varlı et al found that the fatty acid subfractions of the endolichenic fungus Phoma sp. EL006848 could efficiently suppress multiple immune checkpoints via the inhibition of the benzo[a]pyrene-induced (an AhR ligand) expression of PD-L1 [90], and a further extensive phytochemical investigation successfully led to the isolation and identification of palmitic acid (399), stearic acid (400), and oleic acid (401), thus unambiguously verifying that the fatty acids from the endolichenic fungi Phoma sp. possessed strong potential for immunotherapy.…”

Section: Othersmentioning

confidence: 88%

“…Moreover, the authors speculated that the presence of a double bond on the side chain in these phomalone derivatives may be essential for their inhibitory effect against NO production. In 2019, two known compounds, (R)-7-hydroxy-3-((S)-1-hydroxyethyl)-5-methoxy-3,4dime-thylisobenzofuran-1(3H)-one (90) and clearanol E (91), were isolated from the EtOAc extract of O. korrae by Li et al [30]. In the same year, Yang et al reported two phomalone derivatives, 1-(2,4-dihydroxy-3-[2-hydroxyethyl]-6-methoxyphenyl)butan-1-one (92) and 1-(2,4-dihydroxy-3-[2-hydroxyethyl]-6-methoxyphenyl)-3-hydroxybutan-1-one (93), which were isolated from the endolichenic fungus Cochliobolus kusanoi [29].…”

Section: Simple Aromatic Polyketidesmentioning

confidence: 99%

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Endolichenic Fungi: A Promising Medicinal Microbial Resource to Discover Bioactive Natural Molecules—An Update

Zhang,

Ran,

et al. 2024

JoF

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Lichens are some of the most unique fungi and are naturally encountered as symbiotic biological organisms that usually consist of fungal partners (mycobionts) and photosynthetic organisms (green algae and cyanobacteria). Due to their distinctive growth environments, including hot deserts, rocky coasts, Arctic tundra, toxic slag piles, etc., they produce a variety of biologically meaningful and structurally novel secondary metabolites to resist external environmental stresses. The endofungi that live in and coevolve with lichens can also generate abundant secondary metabolites with novel structures, diverse skeletons, and intriguing bioactivities due to their mutualistic symbiosis with hosts, and they have been considered as strategically significant medicinal microresources for the discovery of pharmaceutical lead compounds in the medicinal industry. They are also of great importance in the fundamental research field of natural product chemistry. In this work, we conducted a comprehensive review and systematic evaluation of the secondary metabolites of endolichenic fungi regarding their origin, distribution, structural characteristics, and biological activity, as well as recent advances in their medicinal applications, by summarizing research achievements since 2015. Moreover, the current research status and future research trends regarding their chemical components are discussed and predicted. A systematic review covering the fundamental chemical research advances and pharmaceutical potential of the secondary metabolites from endolichenic fungi is urgently required to facilitate our better understanding, and this review could also serve as a critical reference to provide valuable insights for the future research and promotion of natural products from endolichenic fungi.

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Section: Othersmentioning

confidence: 88%

Section: Simple Aromatic Polyketidesmentioning

confidence: 99%

Endolichenic Fungi: A Promising Medicinal Microbial Resource to Discover Bioactive Natural Molecules—An Update

Zhang,

Ran,

et al. 2024

JoF

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“…Notably, BbOle1 gene in B. bassiana was targeted by HapX, a bZIP-type TF, which controlled the amount of oleic acid (OA) ( 13 ). According to recent investigations, human pathogenic fungi ( Pseudevernia furfuracea and Malassezia sympodialis ) can release OA and decrease the host’s immune response ( 29 , 30 ). This suggests that OA can assist pathogenic fungi withstand the immune responses of host insects.…”

Section: Introductionmentioning

confidence: 99%

The basic leucine zipper domain (bZIP) transcription factor BbYap1 promotes evasion of host humoral immunity and regulates lipid homeostasis contributing to fungal virulence in Beauveria bassiana

Wang,

Chen,

Zhang

et al. 2024

mSphere

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Basic leucine zipper domain transcription factors (TFs), of which yeast activator protein (Yap) is a significant class, are crucial for the development of sclerotia, the stress response, vegetative growth, and spore adhesion. Nevertheless, nothing is known about how Yap TFs contribute to the pathogenicity of entomopathogenic fungus. In this work, Beauveria bassiana was used to identify and knock out the yeast gene BbYap1 , which is similar to Yap. The BbYap1 gene deletion has an impact on lipid homeostasis of B. bassiana ; oleic acid, for example, dropped by 95.69%. The BbYap1 mutant exhibited much less virulence and vegetative development in comparison to the wild strain, while demonstrating a greater sensitivity to chemical stress. It is noteworthy that the physiological abnormalities brought on by BbYap1 deletion were largely repaired by the addition of exogenous oleic acid, as seen by the notable increase in insect survival in the blood cavity injection group. Following infection with the BbYap1 mutant, the host exhibits a considerable down-regulation of the expression of β-1,3-glucan recognition protein, gallerimycin, gloverin, and moricin-like protein genes. Likewise, the introduction of exogenous oleic acid markedly increased the host’s expression of the aforementioned genes. In summary, BbYap1 regulates cellular enzyme lipid homeostasis and fungal virulence by eluding host humoral defense, which contributes to fungal chemical stress and vegetative development. IMPORTANCE Entomopathogenic fungi (EPF) offer an effective and eco-friendly alternative to curb insect populations in biocontrol strategy. When EPF enter the hemolymph of their host, they encounter a variety of stress reactions, such as immunological and oxidative stress. Basic leucine zipper domain transcription factors, of which yeast activator protein (Yap) is a significant class, have diverse biological functions related to metabolism, development, reproduction, conidiation, stress responses, and pathogenicity. This study demonstrates that BbYap1 of Beauveria bassiana regulates cellular enzyme lipid homeostasis and fungal virulence by eluding host humoral defense, which contributes to fungal chemical stress and vegetative development. These findings offer fresh perspectives for comprehending molecular roles of YAP in EPF.

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Unveiling the antimetastatic activity of monoterpene indole alkaloids targeting MMP9 in cancer cells, with a focus on pharmacokinetic and cellular insights

Varlı,

Lee,

Kang

et al. 2024

Molecules and Cells

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A fatty acid-rich fraction of an endolichenic fungus Phoma sp. suppresses immune checkpoint markers via AhR/ARNT and ESR1

Cited by 4 publications

References 57 publications

Endolichenic Fungi: A Promising Medicinal Microbial Resource to Discover Bioactive Natural Molecules—An Update

Endolichenic Fungi: A Promising Medicinal Microbial Resource to Discover Bioactive Natural Molecules—An Update

The basic leucine zipper domain (bZIP) transcription factor BbYap1 promotes evasion of host humoral immunity and regulates lipid homeostasis contributing to fungal virulence in Beauveria bassiana

Unveiling the antimetastatic activity of monoterpene indole alkaloids targeting MMP9 in cancer cells, with a focus on pharmacokinetic and cellular insights

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