A favorable maternal and neonatal outcome following chemotherapy with etoposide, bleomycin, and cisplatin for management of grade 3 immature teratoma of the ovary

Ghaemmaghami, Fatemeh; Abbasi, Fatemeh; Abadi, Akram Ghahghai Nezam

doi:10.3802/jgo.2009.20.4.257

Cited by 29 publications

(19 citation statements)

References 9 publications

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“…Giant ovarian teratomas commonly present with acute abdominal pain caused by adnexal torsion (9) and abdominal distention due to the rapid growth of a large, unilateral tumor undergoing capsular distention, hemorrhage or necrosis (10). The patients may also have certain non-specific abdominal complaints indicating mass effect, including menoxenia, dyspnea and the symptoms of other organs becoming influenced by the tumor.…”

Section: Discussionmentioning

confidence: 99%

Management of giant ovarian teratoma: A case series and review of the literature

Wang

Liu

et al. 2012

Oncology Letters

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Abstract. The management of ovarian teratomas in normal conditions is well established, but in rare giant cases (tumor diameter over 15 cm), the choice of management, such as laparotomic or laparoscopic approaches, are controversial and may be therapeutically challenging for surgeons. The aims of the current study were to analyze the clinical features of giant ovarian teratoma and to discuss its management. The clinical data of 330 patients with giant ovarian teratoma (of whom 1 patient was treated by the authors and 329 were admitted to the Second Affiliated Hospital of Zhejiang University Medical College between January 1st 2000 and December 31st 2010) were reviewed and analyzed. The patients had an age range of 6 to 83 years and a mean tumor size of 24.9±7.1 cm. Of the 330 patients, 102 (30.9%) were asymptomatic and the majority (69.1%, 228/330) reported symptoms. There were more patients in the laparotomic group than the laparoscopic group, especially for the emergency cases (5.5 vs. 0%, P<0.05). Accidental cyst rupture was more frequent when a laparoscopic approach was used (31.5 vs. 19.6%, P<0.05). These results suggest that laparotomic resection may be preferred for the en bloc mass removal, adequate abdominal cavity irrigation and avoidance of accidental mass rupture in the management of giant ovarian teratomas. Familiarity with the imaging features of giant ovarian teratomas effectively aids preoperative diagnosis and differentiation.

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Section: Discussionmentioning

confidence: 99%

Management of giant ovarian teratoma: A case series and review of the literature

Wang

Liu

et al. 2012

Oncology Letters

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“…It may be administered during pregnancy [ 1 , 17 , 18 ], and has been considered safe for the fetus if given during the second or third trimester, with births of healthy babies reported (e.g. [ 19 – 21 ]. However, no data have been reported on possible detrimental effects of etoposide on the reproductive systems of these children, with none having yet reached puberty.…”

Section: Introductionmentioning

confidence: 99%

Etoposide damages female germ cells in the developing ovary

et al. 2016

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BackgroundAs with many anti-cancer drugs, the topoisomerase II inhibitor etoposide is considered safe for administration to women in the second and third trimesters of pregnancy, but assessment of effects on the developing fetus have been limited. The purpose of this research was to examine the effect of etoposide on germ cells in the developing ovary. Mouse ovary tissue culture was used as the experimental model, thus allowing us to examine effects of etoposide on all stages of germ cell development in the same way, in vitro.ResultsFetal ovaries from embryonic day 13.5 CD1 mice or neonatal ovaries from postnatal day 0 CD1 mice were cultured with 50–150 ng ml−1 or 50–200 ng ml−1 etoposide respectively, concentrations that are low relative to that in patient serum. When fetal ovaries were treated prior to follicle formation, etoposide resulted in dose-dependent damage, with 150 ng ml−1 inducing a near-complete absence of healthy follicles. In contrast, treatment of neonatal ovaries, after follicle formation, had no effect on follicle numbers and only a minor effect on follicle health, even at 200 ng ml−1. The sensitivity of female germ cells to etoposide coincided with topoisomerase IIα expression: in the developing ovary of both mouse and human, topoisomerase IIα was expressed in germ cells only prior to follicle formation.ConclusionsExposure of pre-follicular ovaries, in which topoisomerase IIα expression was germ cell-specific, resulted in a near-complete elimination of germ cells prior to follicle formation, with the remaining germ cells going on to form unhealthy follicles by the end of culture. In contrast, exposure to follicle-enclosed oocytes, which no longer expressed topoisomerase IIα in the germ cells, had no effect on total follicle numbers or health, the only effect seen specific to transitional follicles. Results indicate the potential for adverse effects on fetal ovarian development if etoposide is administered to pregnant women when germ cells are not yet enclosed within ovarian follicles, a process that starts at approximately 17 weeks gestation and is only complete towards the end of pregnancy.Electronic supplementary materialThe online version of this article (doi:10.1186/s12885-016-2505-9) contains supplementary material, which is available to authorized users.

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“…Giant ovarian teratomas commonly present with acute abdominal pain caused by adnexal torsion, and unilateral tumour undergoing capsular distension, haemorrhage or necrosis 9,10 . They may present with abdominal distension due to rapid growth of the tumour.…”

Section: Discussionmentioning

confidence: 99%

Management of giant ovarian teratoma

Pradhan

Sherpa

Joshi

et al. 2014

J. Kathmandu Med. Coll.

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Sabita Pathak, third year Resident,5 Meeta Thapa, second year Resident,6 Basanta Sharma, fi rst year Resident, Department of Obstetrics and Gynaecology, Nepal Medical College Teaching Hospital, Kathmandu, Nepal AbstractThe management of ovarian teratoma in normal condition is well established but in rare giant tumour (diameter over 15 cm) management approaches such as laparoscopy or laparotomy are controversial and may be therapeutically challenging for surgeons. Laparotomic resection is the preferred method for the en-block mass removal, adequate abdominal cavity irrigation, and avoidance of accidental mass rupture during management of giant ovarian teratoma.Here we discuss a case of a 43 year old multiparous lady suffering from a huge ovarian tumour of size 40 cm, admitted in Nepal Medical College Teaching Hospital on 15th May 2013. This patient underwent laparotomy on 21st May 2013 and left sided huge multiloculated ovarian cystic teratoma was removed en-bloc with no complications.

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A favorable maternal and neonatal outcome following chemotherapy with etoposide, bleomycin, and cisplatin for management of grade 3 immature teratoma of the ovary

Cited by 29 publications

References 9 publications

Management of giant ovarian teratoma: A case series and review of the literature

Management of giant ovarian teratoma: A case series and review of the literature

Etoposide damages female germ cells in the developing ovary

Management of giant ovarian teratoma

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