A Feasibility Study of Alcoholic-Alkaline Treated Rice Starch for Disintegrant in Tablet

Abstract

The objectives of this research were to study the properties of alcoholic-alkaline treated rice starch (Modified rice starch, MRS) and to investigate the properties of tablet using propranolol HCl as a model drug. The properties of MRS, a tablet disintegrant were compared with a commercial product of sodium starch glycolate (Explotab ®). The result showed that starch granule and gelatinization endotherm of MRS was not evident. The swelling capacity of MRS in distilled water, 0.1 M hydrochloric acid and phosphate buffer (pH 6.8) was similar. Disintegration time and friability of MRS was decreased, hardness was 6-7 kp and drug release was increased. These properties were similar to tablet using Explotab ®. It can be concluded that MRS can be used as a disintegrant and its displayed feasibility for fast disintegrated tablet.