A feasibility study of percutaneous radiofrequency ablation followed by radiotherapy in the management of painful osteolytic bone metastases

Staso, Mario Di; Zugaro, Luigi; Gravina, Giovanni Luca; Bonfili, Pierluigi; Marampon, Francesco; Nicola, L. Di; Conchiglia, Armando; Ventura, Lori M.; Franzese, Pietro; Gallucci, M.; Masciocchi, Carlo; Tombolini, Vincenzo

doi:10.1007/s00330-011-2133-3

Cited by 82 publications

(41 citation statements)

References 12 publications

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“…In particular, RF ablation (RFA), is a minimally invasive technique that uses electrical currents (≈500 kHz) to heat the target biological tissue. It has been increasingly used in recent years for the treatment of cancer in the liver [1], kidney [2], bone [3], breast [4], prostate [5] and lung [6].…”

Section: Introductionmentioning

confidence: 99%

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Review of the mathematical functions used to model the temperature dependence of electrical and thermal conductivities of biological tissue in radiofrequency ablation

Trujillo

Berjano

2013

International Journal of Hyperthermia

126

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Purpose: Although theoretical modeling is widely used to study different aspects of radiofrequency ablation (RFA) its utility is directly related to its realism. An important factor in this realism is the use of mathematical functions to model the temperaturedependence of tissue thermal (k) and electrical () conductivities. Our aim was to review the piecewise mathematical functions most commonly used for modeling the temperaturedependence of k and  in RFA computational modeling. Materials and methods:We built a hepatic RFA theoretical model of a cooled electrode and compared lesion dimensions and impedance evolution with combinations of mathematical functions proposed in previous studies We employed the thermal damage contour D63 to compute the lesion dimension contour, which corresponds to Ω= 1, Ω being local thermal damage assessed by the Arrhenius damage model. Results:The results were very similar in all cases in terms of impedance evolution and lesion size after 6 minutes of ablation. Although the relative differences between cases in terms of time to first roll-off (abrupt increase in impedance) were as much as 12%, the maximum relative differences in terms of the short lesion (transverse) diameter were below 3.5%. Conclusions:The findings suggest that the different methods of modeling temperature dependence of k and  reported in the literature do not significantly affect the computed lesion diameter.3

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Section: Introductionmentioning

confidence: 99%

“…0.026 70 1045 1080 (3) 3455 (3) Liver 0.132 (1) 0.502 (2) 370 (4) 2156 (4) electric conductivity; k, thermal conductivity; density; c, specific heat (1) Assessed at 17ºC. This allows initial impedance (≈100  to match the experimental mean value obtained from [30].…”

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confidence: 99%

Review of the mathematical functions used to model the temperature dependence of electrical and thermal conductivities of biological tissue in radiofrequency ablation

Trujillo

Berjano

2013

International Journal of Hyperthermia

126

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“…Conversely, the cytotoxic temperatures generated at the center of an ablation volume dissipate with distance, resulting in less reliable necrosis of the tumor periphery. In a preliminary cohort study, Di Staso et al [65] compared the pain responses of 15 patients with solitary skeletal metastases treated with RFA followed by cEBRT (20 Gy in 5 fractions) with 30 patients treated with cEBRT alone. At 12-week follow-up, patients in the combined treatment group more frequently reported both complete (53% [8 of 15] radiation-and ablation-induced VCF emerge, the long-term clinical benefit of prophylactic vertebral augmentation will need to be evaluated [66].…”

Section: Future Researchmentioning

confidence: 99%

The Metastatic Spine Disease Multidisciplinary Working Group Algorithms

et al. 2015

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The Metastatic Spine Disease Multidisciplinary Working Group consists of medical and radiation oncologists, surgeons, and interventional radiologists from multiple comprehensive cancer centers who have developed evidence-and expert opinionbased algorithms for managing metastatic spine disease. The purpose of these algorithms is to facilitate interdisciplinary referrals by providing physicians with straightforward recommendations regarding the use of available treatment options, including emerging modalities such as stereotactic body radiation therapy and percutaneous tumor ablation. This consensus document details the evidence supporting the Working Group algorithms and includes illustrative cases to demonstrate how the algorithms may be applied. The Oncologist 2015;20:1205-1215Implications for Practice: The Metastatic Spine Disease Multidisciplinary Working Group algorithms can facilitate interdisciplinary referrals by providing physicians with straightforward recommendations regarding available treatment options, including emerging modalities such as stereotactic body radiation therapy and percutaneous tumor ablation.

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“…[1][2][3][4][5][6][7][8][9][10][11] Conversely, benign diseases are still under investigation and, so far, the treatment of only osteoid osteoma has appeared in literature. [12][13][14][15] There is scarce literature describing the characteristics and the treatment of benign lesions other than osteoid osteoma, 16 and the studies are usually restricted to a low number of patients.…”

Section: Introductionmentioning

confidence: 99%

Treatment of focal benign lesions of the bone: MRgFUS and RFA

Masciocchi

Arrigoni

Marra

et al. 2016

BJR

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The objective of this study was to evaluate the role of MR-guided focused ultrasound surgery and radiofrequency ablation in the management of bone and soft-tissue lesions. Musculoskeletal interventional radiology represents an interesting option for the treatment of benign bone and soft-tissue lesions to avoid the invasiveness of surgery and related risks. The imaging techniques now available, besides representing an optimal guide, allow control of the temperature reached in the region of interest, avoiding or minimizing damage to the sensitive structures surrounding the lesion. INTRODUCTIONInterventional radiology (IR) procedures are well established in the treatment of malignant, particularly metastatic, diseases of bone and soft tissues and are exhaustively described in literature.

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A feasibility study of percutaneous radiofrequency ablation followed by radiotherapy in the management of painful osteolytic bone metastases

Abstract: Our results suggest that RFA-RT is safe and more effective than RT. The findings described here should serve as a framework around which to design future clinical trials.

Cited by 82 publications

References 12 publications

Review of the mathematical functions used to model the temperature dependence of electrical and thermal conductivities of biological tissue in radiofrequency ablation

Review of the mathematical functions used to model the temperature dependence of electrical and thermal conductivities of biological tissue in radiofrequency ablation

The Metastatic Spine Disease Multidisciplinary Working Group Algorithms

Treatment of focal benign lesions of the bone: MRgFUS and RFA

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