A feasibility study on oxidation state of arsenic in cut tobacco, mainstream cigarette smoke and cigarette ash by X-ray absorption spectroscopy

Liu, C.; Jin, Hu; McAdam, Kevin

doi:10.1016/j.sab.2009.10.005

Cited by 16 publications

(21 citation statements)

References 20 publications

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“…The presence of arsenite (As(III)) could not be verified using this method because As(III) species appears to elute in the chromatographic void volume. Interestingly, recent XANES results had revealed that the 3R4F cut tobacco contained almost exclusively As(V) 4 in broad agreement with the findings of this study.…”

Section: Arsenic Speciation Analysis Of Cut Tobaccosupporting

confidence: 93%

“…Recently synchrotron-based X-ray Absorption Near-Edge Structure (XANES) spectroscopy was applied to study the oxidation state of As in cut tobacco, cigarette mainstream smoke and cigarette ash. 4 Although the qualitative results obtained revealed the complex oxidation in which As is involved during the cigarette smoking process, no identification of the As species mediating such processes could be achieved due to the low content of As in the samples.…”

Section: Introductionmentioning

confidence: 92%

“…The concentration of water-soluble As represents approximately 31% of the total As in the solid smoke condensate (0.45 mg kg À1 As, as previously reported elsewhere). 4 Fig. 5A shows the As profile of a water extract of mainstream smoke condensate stored at À80 C, immediately after being received (in dry ice).…”

Section: Water-soluble Arsenic Speciation Of Mainstream Smoke Condens...mentioning

confidence: 99%

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Determination of total arsenic and arsenic speciation in tobacco products: from tobacco leaf and cigarette smoke

Taebunpakul

Liu

Wright

et al. 2011

J. Anal. At. Spectrom.

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Section: Arsenic Speciation Analysis Of Cut Tobaccosupporting

confidence: 93%

Section: Introductionmentioning

confidence: 92%

Section: Water-soluble Arsenic Speciation Of Mainstream Smoke Condens...mentioning

confidence: 99%

See 1 more Smart Citation

Determination of total arsenic and arsenic speciation in tobacco products: from tobacco leaf and cigarette smoke

Taebunpakul

Liu

Wright

et al. 2011

J. Anal. At. Spectrom.

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“…It was relatively straightforward for XANES spectra to reveal the dominant arsenic species as As(V) in both ground 3R4F tobacco and the cigarette ash samples, based on the K-edge position of the As(III) and As(V) standards (7). Grinding and pelleting the cut tobacco and ash samples were useful to improve the signal-to-noise ratio.…”

Section: Main Experimental Resultsmentioning

confidence: 99%

“…This experiment was conducted at either Station 16.5 (Daresbury Synchrotron Radiation Source, UK) or Beamline X1 (HASYLAB, Hamburg, Germany). Further experimental details and data processing protocols are available elsewhere (7).…”

Section: X-ray Absorption Near Edge Structure (Xanes) Analysismentioning

confidence: 99%

Arsenic Speciation in Tobacco and Cigarette Smoke

Liu

Wright

McAdam

et al. 2012

Beiträge Zur Tabakforschung International/Contributions to Tobacco Research

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Arsenic is one of the metals found in cured tobacco and mainstream cigarette smoke. Levels of arsenic in modern filtered cigarette smoke range from sub-ppm to a few tens of ppms. To enable accurate smoke toxicity assessment on arsenic in cigarette smoke, it is desirable to establish its chemical forms in addition to total quantities because different arsenic compounds possess different toxicological potentials.Progress has been made on measuring the arsenic speciation in tobacco and mainstream cigarette smoke by using a combination of synchrotron-based X-ray absorption spectroscopy and high-performance liquid chromatography- inductively coupled plasma mass spectrometry (HPLC-ICP-MS). In this paper, we describe the experimental procedures developed together with the main findings. A transient redox transformation between As(V) and As(III) was confirmed in freshly generated mainstream smoke. Potential areas for future research are highlighted in order to further our understanding of the speciation mechanism for arsenic in tobacco products.

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Fractionation of cadmium in tobacco and cigarette smoke condensate using XANES and sequential leaching with ICP-MS/MS

Cuello-Nuñez¹,

Benning

Liu

et al. 2018

Anal Bioanal Chem

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Fractionation data for cadmium in tobacco products, as obtained by sequential leaching of cadmium species with ICP-MS/MS analysis, and separately by X-ray absorption near edge structure (XANES) are presented here for the first time. The total amount of cadmium found in 3R4F cigarette cut tobacco was 1526 ± 42 μg kg, of which 5% was found in the smoke under ISO smoking conditions. XANES analysis showed that Cd in tobacco, cigarette smoke and ash was present in the + 2 oxidation state. Examination of the gas-particle partitioning of smoke cadmium suggests that Cd in mainstream smoke is best viewed as semi-volatile, existing in both particulate and gas phases. Sequential extraction of trapped tobacco smoke was carried out to get a deeper insight into the chemistry of cigarette smoke cadmium compounds. Consecutive extractions with ultrapure water, dilute (1%) nitric acid and 10% nitric acid led to extraction of a total amount of Cd which agreed with that obtained after microwave digestion of the whole sample, suggesting that cadmium was quantitatively leachable into aqueous/acidic solutions. Most Cd (~ 90% of the total Cd in the smoke condensate) was extracted into dilute nitric acid (likely as CdO, Cd(OH) and CdCO) with a minor percentage (3%) extracted into water (likely as CdCl) and in 10% nitric acid (likely as CdS). Extraction of trapped mainstream smoke with pentane, followed by ICP-MS/MS analysis, to examine the possible presence of organocadmium in 3R4F tobacco smoke, did not show the presence of organocadmium compounds above the method LOQ (2 μg kg), possibly due to their reactivity under the experimental conditions. The high selectivity with sufficient sensitivity achieved by ICP-MS/MS was invaluable to quantify Cd (at low μg kglevels) simultaneously with sulphur and chlorine in the tobacco smoke fractions of complex matrix. The cadmium chemistry in the smoke, identified in this study, is consistent with both relatively high lung absorption and DNA binding; both potentially important factors for disease progression in smokers. Graphical Abstract This paper provides quantitative fractionation data for cadmium in tobacco and smoke by using sequential leaching with ICPMS and XANES.

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A feasibility study on oxidation state of arsenic in cut tobacco, mainstream cigarette smoke and cigarette ash by X-ray absorption spectroscopy

Cited by 16 publications

References 20 publications

Determination of total arsenic and arsenic speciation in tobacco products: from tobacco leaf and cigarette smoke

Determination of total arsenic and arsenic speciation in tobacco products: from tobacco leaf and cigarette smoke

Arsenic Speciation in Tobacco and Cigarette Smoke

Fractionation of cadmium in tobacco and cigarette smoke condensate using XANES and sequential leaching with ICP-MS/MS

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