2022
DOI: 10.1038/s41598-022-22186-0
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A feasibility study using sodium alginate injection for penetrating abdominal trauma in a swine model

Abstract: Penetrating abdominal injury is a major cause of death in trauma. Sodium alginate hydrogel, a hemostatic agent, offers a platform for targeting both mechanical and biological injuries. The current study assessed the effect of Very Low Viscosity (high) G (VLVG) alginate following abdominal trauma in a swine model of penetrating abdominal injury. Seven anesthetized pigs were instrumented with invasive monitoring catheters and abdominal trauma was introduced by laparoscopic hepatectomy. Ten minutes after the indu… Show more

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“…It is a hydrophilic linear polysaccharide composed of β-D-mannuronic acid and α-L-guluronic acid obtained from brown algae. Due to its biocompatibility, biodegradability, non-immunogenicity, gel-forming properties and its structural similarity to the extra cellular matrix, Alg is used for biomedical applications [12,[15][16][17][18].…”
Section: Introductionmentioning
confidence: 99%
“…It is a hydrophilic linear polysaccharide composed of β-D-mannuronic acid and α-L-guluronic acid obtained from brown algae. Due to its biocompatibility, biodegradability, non-immunogenicity, gel-forming properties and its structural similarity to the extra cellular matrix, Alg is used for biomedical applications [12,[15][16][17][18].…”
Section: Introductionmentioning
confidence: 99%