A Feedback Control Approach to Organic Drug Infusions Using Electrochemical Measurement

Myers, Mark H.; Li, Yaqin; Kivlehan, Francine; Lindner, Ernő; Chaum, Edward

doi:10.1109/tbme.2015.2464771

Cited by 8 publications

(6 citation statements)

References 13 publications

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“…In the study, conducted by Myers et al in [32], a PID controller is triggered after the bolus injection is injected. A minor amount of fluctuation in drug concentration is observed.…”

Section: Methodsmentioning

confidence: 99%

“…Finally, the PI controller is tuned by using parameter 5 to control the closed-loop drug delivery. The parameter set employed in our simulation study is identified from the experimental and simulation parameters in [32]. …”

Section: Methodsmentioning

confidence: 99%

“…The design process of phase-lead, lag, lead-lag, and cascaded lead controllers is performed by applying the principles of the root locus technique [26-28], using MATLAB SISOTOOL [29-31]. The simulation study is based on the model developed by Myers et al in [32]. …”

Section: Introductionmentioning

confidence: 99%

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A Comparative Analysis of PID, Lead, Lag, Lead-Lag, and Cascaded Lead Controllers for a Drug Infusion System

Jadoon

Shakeel

Saleem

et al. 2017

Journal of Healthcare Engineering

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Goal The aim of this paper is to conduct a comprehensive comparative analysis between five different controllers for a drug infusion system in total intravenous anesthesia (TIVA) administration. Methods The proposed method models a dilution chamber with first order exponential decay characteristics to represent the pharmacokinetic decay of a drug. The dilution chamber is integrated with five different control techniques with a simulation-based comparative analysis performed between them. The design process is conducted using MATLAB SISOTOOL. Results The findings show that each controller has its own merits and demerits. The results generated using MATLAB signify and confirm the effectiveness of PI and cascaded lead controllers, with cascaded lead controller as the best control technique to automate and control the propofol delivery. Conclusion In this paper, different control techniques for measurement-based feedback-controlled propofol delivery is confirmed with promising results. Significance The comparative analysis showed that this drug infusion platform, merged with the proper control technique, will perform eminently in the field of total intravenous anesthesia.

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“…In the study, conducted by Myers et al in [32], a PID controller is triggered after the bolus injection is injected. A minor amount of fluctuation in drug concentration is observed.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

A Comparative Analysis of PID, Lead, Lag, Lead-Lag, and Cascaded Lead Controllers for a Drug Infusion System

Jadoon

Shakeel

Saleem

et al. 2017

Journal of Healthcare Engineering

View full text Add to dashboard Cite

show abstract

“…Consider the drug delivery system in biomedical engineering (e.g., the intravenous (IV) bag associated with the intravenous therapy), the mathematical model of which can be represented as follows [17, 24]:

{\overset{x}{true}}_{1} false(t false) = - a false(t false) x_{1} false(t false) + b false(t false) x_{2} false(t false),

{\overset{x}{true}}_{2} false(t false) = - c false(t false) x_{2} false(t false) + u false(t false),

where the state

x_{1} false(t false) \in ([], x_{1 m}, x_{1 M})

and

x_{2} false(t false) \in ([], x_{2 m}, x_{2 M})

denote the drug concentration level and infusion rate of the human body, the control u ( t ) denotes the drug delivery rate to the human body. Note that it will cause severe discomfort of the human body if the state x exceeds the specified range.…”

Section: Application To Drug Delivery Systemmentioning

confidence: 99%

“…In this section, we will analyze the overall performance of the system under the proposed control (66). (24), and Q (63)-(64). Suppose that the system is subject to Assumptions 1-6, the control (66) can guarantee the uniform boundedness and uniform ultimate boundedness of the system Q.…”

Section: Performance Analysis Of the Proposed Controlmentioning

confidence: 99%

Guaranteeing performance for uncertain nonlinear systems with bounded state constraint and mismatching condition

Fang

Chen

et al. 2019

Asian Journal of Control

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The control design problem for the uncertain nonlinear system with bounded state constraint and mismatching condition is considered in this paper. The uncertainty in the system, which may be due to unknown system parameters and external disturbance, is nonlinear and time‐varying. The state of the system is constrained to be bounded. The system does not satisfy the (global) matching condition. A creative one‐to‐one state transformation is proposed by converting the bounded states into the unbounded ones. A step‐by‐step state transformation is proposed to convert the mismatched system into a matched system. The robust control is then proposed based on the transformed system. The control is demonstrated to be able to guarantee the uniform boundedness and uniform ultimate boundedness of the system in the presence of uncertainty, while the state constraint can be always guaranteed.

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Intelligent automated drug administration and therapy: future of healthcare

Sharma

Singh²,

Gaur

et al. 2021

Drug Deliv. and Transl. Res.

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A Feedback Control Approach to Organic Drug Infusions Using Electrochemical Measurement

Abstract: This platform will contribute to high-performance TIVA application of intravenous propofol anesthesia.

Cited by 8 publications

References 13 publications

A Comparative Analysis of PID, Lead, Lag, Lead-Lag, and Cascaded Lead Controllers for a Drug Infusion System

A Comparative Analysis of PID, Lead, Lag, Lead-Lag, and Cascaded Lead Controllers for a Drug Infusion System

Guaranteeing performance for uncertain nonlinear systems with bounded state constraint and mismatching condition

Intelligent automated drug administration and therapy: future of healthcare

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