2019
DOI: 10.1101/654863
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A feedback loop of conditionally stable circuits drives the cell cycle from checkpoint to checkpoint

Abstract: We perform logic-based network analysis on a model of the mammalian cell cycle. This model is composed of a Restriction Switch driving cell cycle commitment and a Phase Switch driving mitotic entry and exit. By generalizing the concept of stable motif, i.e., a self-sustaining positive feedback loop that maintains an associated state, we introduce the concept of conditionally stable motif, the stability of which is contingent on external conditions. We show that the stable motifs of the Phase Switch are conting… Show more

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“…Connections among virtual nodes encode the update functions. The structure of this auxiliary network tightly constrains the attractors of a system (33,49,50). The expanded network can be used to identify control strategies that drive the system to a desired attractor (51,52).…”
Section: Introductionmentioning
confidence: 99%
“…Connections among virtual nodes encode the update functions. The structure of this auxiliary network tightly constrains the attractors of a system (33,49,50). The expanded network can be used to identify control strategies that drive the system to a desired attractor (51,52).…”
Section: Introductionmentioning
confidence: 99%