A fibrinogen biosensing platform based on plasmonic Ga nanoparticles and aminosilane–titanate antibody trapping

Magdaleno, Alvaro J.; Gordillo, N.; Pau, J. L.; Manso‐Silván, Miguel

doi:10.1002/mds3.10083

Cited by 3 publications

(5 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The diverse surface functionalization of Ga LM makes Ga-based LM plasmon resonance biosensors highly promising for various applications. Using a similar method, as shown in Figure 10b, Magdaleno et al [78] prepared an aminosilane-titanate trapping layer to modify the Ga LM NPs platform at the first step, followed by bio specific functionalization of the platform using IGGs to capture plasma protein Fibrinogen (Fbg). [79] Bovine serum albumin was used to [65] Copyright 2007, American Physical Society; b) Switching of plasmonic response in Ga core-shell structure.…”

Section: Optical Sensormentioning

confidence: 99%

“…Using a similar method, as shown in Figure 10b, Magdaleno et al. [ 78 ] prepared an aminosilane‐titanate trapping layer to modify the Ga LM NPs platform at the first step, followed by bio specific functionalization of the platform using IGGs to capture plasma protein Fibrinogen (Fbg). [ 79 ] Bovine serum albumin was used to prevent Fbg from interacting nonspecifically with the surface.…”

Section: Applications Based On the Optical Properties Of Lmsmentioning

confidence: 99%

Section: Applications Based On the Optical Properties Of Lmsmentioning

confidence: 99%

“…Copyright 2016, The Royal Society of Chemistry; b) Biospecific functionalization of Ga-based LM sensor platform to detect Fbg. Reproduced with permission [78]. Copyright 2020, Wiley-VCH; c) Ga-based LM plasmonic oxide frameworks for Raman detective sensor platform.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Gallium‐Based Liquid Metals: Optical Properties, Applications, and Challenges

Wu,

Fang,

et al. 2023

Advanced Optical Materials

View full text Add to dashboard Cite

Originating from the intrinsic metallic and liquid natures, gallium‐based liquid metals (Ga‐based LMs) have been greatly developed in the research of soft electronics, chemical synthesis, and other fields due to their fascinating characteristics. Meanwhile, the development and application of metal optics can help modern medicine and industry reach rapid developmental stages, such as disease imaging, photothermal treatment, and sensor detection. However, Ga‐based LMs have been much less explored in terms of their optical properties, particularly liquid alloys, and few reviews have contributed to their photonic applications. Ga‐based LMs can achieve wideband‐tunable plasmonic resonance and exhibit characteristic optical responses owing to their unique polymorphisms, undercooling, and superior mobility. Ga‐based LMs have broad applications in optical switches and memory, optical sensors, light sources, light‐driven micro or nano‐robots, photoacoustic imaging, and controllable metamaterials. In this study, recent progress in the optical properties of Ga‐based LMs and their potential applications are summarized. Current challenges in optical applications and future perspectives in this research field are summarized and discussed.

show abstract

Section: Optical Sensormentioning

confidence: 99%

Section: Applications Based On the Optical Properties Of Lmsmentioning

confidence: 99%

Section: Applications Based On the Optical Properties Of Lmsmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Gallium‐Based Liquid Metals: Optical Properties, Applications, and Challenges

Wu,

Fang,

et al. 2023

Advanced Optical Materials

View full text Add to dashboard Cite

show abstract

“…In the present work we aim at describing through Montecarlo simulations the surface segregation by kinetic demixing taking place in hybrid organosilane/Ti-alkoxide (OrgSil/Ti-alk) xerogels. This surface segregation has been in fact used previously to activate antibody immobilization in biosensors [53,54] or DNA in micro-arrays [55], to study the adsorption of viral capsids [56] and condition cell-adhesion [57]. To compare the simulations with experiments, we propose the determination of in-depth concentration profiles of the OrgSil/Ti-alk condensates through hard x-ray photoelectron spectroscopy, a non-destructive technique allowing the description of gradients of matter in the range of tens of nanometers [58,59], a scale matching perfectly the typical thickness of the OrgSil/Ti-alk functionalization layers.…”

Section: Introductionmentioning

confidence: 99%

Montecarlo Simulation and HAXPES Analysis of Organosilane Segregation in Titania Xerogel Films; Towards a Generic Surface Chemofunctionalization Process

et al. 2020

Self Cite

View full text Add to dashboard Cite

The formation of xerogels implies a sequence of hydrolysis and condensation reactions, which are intricate to analyze in heteromolecular sols. We analyze by probabilistic Montecarlo methods the development of hybrid organosilane–titania xerogels and illustrate how partial charges of the reacting molecules can help estimating relative probabilities for the condensation of the molecules. Since the condensation rate of Ti alkoxides is much higher than the corresponding rate of Si alkoxides (especially if bearing a non-hydrolizable group), by imposing a fast condensation process in agreement with low pH kinetics, the process leads to a surface segregation of the organosilane. The simulation results are compared with results of characterization of thin condensates of two different organosilanes within a titanium–isopropoxide matrix. Non-destructive in-depth profiles were obtained by hard x-ray photoelectron spectroscopy, which can resolve through estimation of Si and specific moieties of the organosilane molecules the progress of the condensation. These results are relevant for the generalization of chemo-functionalization processes by kinetic demixing of organosilanes, which have myriad applications in biomedicine and biotechnology.

show abstract

Real‐Time Detection of Fibrinogen via Imprinted Recognition Sites

et al. 2021

View full text Add to dashboard Cite

In this study, the fibrinogen imprinted surface plasmon resonance (SPR) biosensor was developed for the monitoring of fibrinogen levels in patient serum samples using a microcontact imprinting method. The fibrinogen imprinted and nonimprinted polymeric films on the SPR chip surface were prepared by the microcontact imprinting approach and characterized by ellipsometer, contact angle measurements, and Fourier transform infrared spectroscopy. The limit of detection and quantification values of the fibrinogen imprinted SPR biosensors in the linear range of 0.05-9.0 mg/mL were 0.00066 and 0.00219 mg/mL, respectively. In all kinetic ana-lyzes, the response time was 11 min for equilibration, adsorption, and desorption cycles. The selectivity studies of SPR biosensors were performed in the presence of fibrinogen, myoglobin, hemoglobin, and immunoglobulin G in a competitive manner. For the validation studies of the fibrinogen imprinted SPR biosensor, the fibrinogen level of diluted patient serum samples was determined by enzyme-linked immunosorbent assay (ELISA). The experimental results show that the serum samples of patients in high and low-risk groups were identified with the recovery of about % 97-99 according to both SPR biosensor and ELISA analysis results.

show abstract

A fibrinogen biosensing platform based on plasmonic Ga nanoparticles and aminosilane–titanate antibody trapping

Cited by 3 publications

References 35 publications

Gallium‐Based Liquid Metals: Optical Properties, Applications, and Challenges

Gallium‐Based Liquid Metals: Optical Properties, Applications, and Challenges

Montecarlo Simulation and HAXPES Analysis of Organosilane Segregation in Titania Xerogel Films; Towards a Generic Surface Chemofunctionalization Process

Real‐Time Detection of Fibrinogen via Imprinted Recognition Sites

Contact Info

Product

Resources

About