A field evaluation of the efficacy of tolfenamic acid and oxytetracycline in the treatment of bovine respiratory disease

Abstract

In a blinded multicentre trial 313 cattle showing clinical signs of respiratory disease were allocated randomly into three groups, treated intramuscularly with a long-acting oxytetracycline formulation at a dose rate of 20 mg/kg bodyweight in combination with vehicle alone (placebo) or with tolfenamic acid at 2 mg/kg bodyweight once or on two occasions with a 48-h interdosing interval. The clinical status of the animals was monitored for 5 days using a specific scoring system and weight gain was calculated between day 0 and day 21. Relapses were monitored from day 5 until day 21. When oxytetracycline was combined with two injections of tolfenamic acid, there was a significant (P < 0.04) improvement in the clinical resolution. This regimen also produced non-significant improvements in cure rate, reduced frequency of relapses and improved weight gain.

Pharmacokinetic–pharmacodynamic integration and modelling of oxytetracycline for the calf pathogensMannheimia haemolyticaandPasteurella multocida

“…In early field studies, usually with small animal numbers, oxytetracycline was reported as effective for metaphylaxis and therapy in cases of calf pneumonia, as assessed by resolution or improvement of clinical signs (Deleforge, Thomas, Davot, & Boisrame, ; Laven & Andrews, ; Morck et al., ; Musser, Mechor, Grohn, Dubovi, & Shin, ). On the other hand, O'Connor et al.…”

Assessment of the duration of the pain response associated with lameness in dairy cows, and the influence of treatment

“…As such, the absence of such a benefi t is not evidence that NSAID are of no benefi t in the treatment of lameness. Tolfenamic acid has proven analgesic and antiinfl ammatory effects in cattle (Deleforge et al 1994;Landoni et al 1995) but our fi rst measurement of nociceptive threshold was made 72 hours after the injection of tolfenamic acid, 24 hours longer than the dosage interval recommended in the product datasheet (Ethical Agents Ltd). Further research is required to quantify the short-term benefi ts of treating lame cattle with NSAID; in particular, data are needed on whether different products have signifi cantly different benefi ts.…”

Pharmacokinetic and pharmacodynamic modelling of marbofloxacin administered alone and in combination with tolfenamic acid in calves

“…In addition, its anti‐inflammatory, antipyretic and antihyperalgesic properties provide a pharmacological basis for its use in combination with antimicrobial drugs, in pneumonias of young calves and pigs. For example, TA has been used for BRD therapy in combination with oxytetracycline (Deleforge et al. , 1994).…”