A field study on the evaluation of day-of-hatch and in grow-out application of live infectious bursal disease virus vaccine in broiler chickens

Ray, Susim Mukul; Ashash, Udi; Muthukumar, Shanthini

doi:10.1016/j.psj.2021.101252

Cited by 10 publications

(15 citation statements)

References 37 publications

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“…However, the bursal lesions may develop later than would be expected from this study in SPF layer-type chickens, due to residual levels of MDA (McCarty et al, 2005;Rautenschlein et al, 2005). Though, the live vaccine can generate the antibody titer quickly, but the live IBD virus vaccine may be neutralized or break through the increased MDA and induce enduring damage to the young broiler chick's immune response (Ray et al, 2021). The factors like vaccine manufacturers guidelines for storage, timing, and due dates, consult veterinarians and health status monitoring before vaccine administration to the birds (Fesseha, 2020).…”

Section: Discussionmentioning

confidence: 66%

Detection of Maternally Derived Antibodies (Mda) Titer and Comparison of Intermediate and Intermediate Plus (Gm-97 Strain) Vaccines of Infectious Bursal Disease Virus

Meher

Islam²,

Gupta³

et al. 2022

J microb biotech food sci

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The Infectious Bursal disease (IBD) is an important devastating disease among the infectious diseases of poultry in Bangladesh. Hence, this study was designed to determine the MDA titer and compare the two commercially available vaccines strains of IBDV (“GM-97 strain Intermediate plus” and “Intermediate type strain”). In this study, a total of 1500 layer birds were equally allocated into three groups (group-A, group-B and control). The Group-A and Group-B were vaccinated by “GM-97 strain Intermediate plus” and “Intermediate type strain” of IBD vaccine, respectively and control was unvaccinated. Blood samples were collected prior to vaccination (1- and 7-days old birds), as well as 7, 14, and 21 days after vaccination. The antibody titer was measured by iELISA test. The highest MDA mean titer was 6227.69±327.63 in day-old birds. The group-A birds had the significantly (p<0.01) higher antibody mean titer than group-B and control. The highest antibody mean titer was 9121.94±657.05 at the age of 39 days in group-A. The MDA titer at 1 days-old had the higher effect size (4.10; CI:4675.36-6072.01; n=16). In group-A, the highest effect size (4.49, CI:5953.80-7556.08; n=16) was in 32 days-old (14 d.p.v.) and the group-B had the highest effect size (3.35; CI:4861.04-6702.59; n=16) was in 32 days-old (14 d.p.v.). Significantly (p<0.01) higher histopathological-lesion scores were 4.75±0.25 and 3.5±0.65 in 32- and 39-days-old respectively in group-A. In brief, the protective level of IBDV MDA titer may remain up to 1 week of post-hatching and the Intermediate plus vaccine can generate higher antibody titer than the intermediate type.

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Section: Discussionmentioning

confidence: 66%

Detection of Maternally Derived Antibodies (Mda) Titer and Comparison of Intermediate and Intermediate Plus (Gm-97 Strain) Vaccines of Infectious Bursal Disease Virus

Meher

Islam²,

Gupta³

et al. 2022

J microb biotech food sci

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“…In broiler production, live attenuated vaccines can be administered via the water supply to protect against viral diseases that affect bird welfare and productivity. Live vaccinations can induce physiological and immunological stresses in flocks (Ray et al, 2021), and there is experimental evidence to suggest that stress responses may increase the susceptibility of chickens to colonization with Campylobacter (Humphrey et al, 2014). In addition, live vaccinations can require the suspension or neutralization of sanitary treatments in the water supply, which may create a window for transmission of Campylobacter via the water system (Zimmer et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

“…bird welfare and productivity. Live vaccinations can induce physiological and immunological stresses in flocks (Ray et al, 2021), and there is experimental evidence to suggest that stress responses may increase the susceptibility of chickens to colonization with…”

Section: Ta B L E 1 (Continued)mentioning

confidence: 99%

UK‐wide risk factor study of broiler carcases highly contaminated with Campylobacter

Smith

Lawes

Davies

et al. 2023

Zoonoses and Public Health

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Campylobacter is a major cause of food poisoning and is typically the most common cause of gastroenteritis in the UK. Data collected at broiler farm and abattoir level, for slaughter batches that were sampled for UK‐wide monitoring, were used to generate two epidemiological risk factor models. A total of 483 batches slaughtered between January 2016 and March 2017 were used in the analysis, coming from 19 abattoirs representing more than 85% of UK broiler production. For each selected slaughter batch, one carcase was sampled after primary chilling and 10 randomly sampled birds had caecal samples collected at the evisceration point. Samples were used for Campylobacter identification and quantification. Two multivariable mixed‐effects models were designed, one with the binary outcome for the detection of a highly contaminated (>1000 colony forming units (CFU)/g) Campylobacter‐positive carcase, whereas the other used the Campylobacter colony count (CFU/g) carcase outcome. The results suggest that caecal colonization within the batch was a key factor for the occurrence of Campylobacter on carcases, and many factors that were identified in the model were also likely to be related to colonization or related to the risk of introduction of Campylobacter from partial depopulation (referred to as thinning) of ~30% of the flock approximately 1 week before full flock depopulation events. The amount of neck skin in the sample was another key factor identified and was included in both models as a risk factor. The models have also identified other factors which may be related to the general health and husbandry on‐farm (use of prebiotics or vaccines, and identification of the product used for drinking line cleaning), whereas the other factors may identify control points related to transmission within a farm. The identification of these variables could help focus control efforts on‐farm, especially for relatively easy improvements, such as improving the provision of house‐specific bird‐weighing buckets/cages in houses.

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“…Over the years, different vaccination strategies have been developed and practiced, such as: live attenuated, inactivated, sub-unit, vectored/recombinant, and immune complexes. Unsurprisingly, each one of these strategies possesses pros and cons, such as efficacy vs. safety, vaccine virus neutralization by MDA vs. impairment of maternal immunity, onset vs. duration of immunity, and finally, the ability to elicit both humoral and cellular immune response [ 10 , 11 , 12 , 13 ]. Nevertheless, live attenuated vaccination mimics infection by the field strain virus; it provides the best host protection to poultry by activating cellular and mucosal immune responses in addition to a humoral response [ 1 , 3 , 10 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Immunization and Host Responses to MB-1, a Live Hatchery Vaccine against Infectious Bursal Disease

Wein

Loeb²,

Asmare³

et al. 2023

Vaccines

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MB-1 is an attenuated infectious bursal disease virus vaccine. Previously, we observed a temporal delay of vaccine virus replication in the bursae of chicks due to maternally derived antibodies (MDAs). The mechanism that allowed its survival despite MDA neutralization remained unclear. We hypothesized that after vaccination at 1 day of age (DOA), the MB-1 virus penetrates and resides in local macrophages that are then distributed to lymphoid organs. Furthermore, MB-1’s ability to survive within macrophages ensures its survival during effective MDA protection. PCR analysis of lymphoid organs from chicks with MDA, vaccinated on 1 DOA, demonstrated that the MB-1 virus was identified at low levels solely in the spleen pre-14 days of age. Fourteen days after vaccination, the virus was identified using PCR in the bursa, with viral levels increasing with time. The possible delay in viral colonization of the bursa was attributed to the presence of anti-IBDV capsid VP2 maternal IgA and IgY in the bursa interstitium. These indicate that during the period of high MDA levels, a small but viable MB-1 viral reservoir was maintained in the spleen, which might have served to colonize the bursa after MDA levels declined. Thereafter, individual immunization of chicks against Gumboro disease was achieved.

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A field study on the evaluation of day-of-hatch and in grow-out application of live infectious bursal disease virus vaccine in broiler chickens

Cited by 10 publications

References 37 publications

Detection of Maternally Derived Antibodies (Mda) Titer and Comparison of Intermediate and Intermediate Plus (Gm-97 Strain) Vaccines of Infectious Bursal Disease Virus

Detection of Maternally Derived Antibodies (Mda) Titer and Comparison of Intermediate and Intermediate Plus (Gm-97 Strain) Vaccines of Infectious Bursal Disease Virus

UK‐wide risk factor study of broiler carcases highly contaminated with Campylobacter

Immunization and Host Responses to MB-1, a Live Hatchery Vaccine against Infectious Bursal Disease

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