A field trial in Thailand of the efficacy of oral fluralaner for the treatment of dogs with generalized demodicosis

Duangkaew, Lerpen; Larsuprom, Lawan; Anukkul, Pojnicha; Lekcharoensuk, Chalermpol; Chen, Charles

doi:10.1111/vde.12524

Cited by 22 publications

(22 citation statements)

References 9 publications

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“…In another uncontrolled eld study involving dogs with generalized demodicosis, in Thailand, a parasitological cure was observed in 100% of dogs (n = 67) within 3 months following treatment with orally administered uralaner [16]. This is consistent with our nding of a day 84 parasitological cure in 100% of dogs treated orally with uralaner and 96.1% of those receiving uralaner spot-on.…”

Section: Discussionsupporting

confidence: 84%

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A European Field Assessment of the efficacy of fluralaner (Bravecto®) chewable and spot-on formulations for treatment of dogs with generalized demodicosis

Petersen

Chiummo

Zschiesche

et al. 2020

Preprint

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Background : Recent reports indicate that the isoxazoline compounds have the potential to provide safe and effective treatment of canine generalized demodicosis, a condition that has been traditionally difficult to cure. Controlled field studies are needed to confirm this potential. A study was therefore initiated to investigate the efficacy of a single oral or spot-on treatment with fluralaner, an isoxazoline, compared with multiple topical treatments with imidacloprid-moxidectin, in dogs naturally affected by generalized demodicosis. Methods : Veterinary clinics in 5 European countries enrolled 134 dogs diagnosed with generalized demodicosis. Dogs were randomized to treatment with either fluralaner chewables, fluralaner spot-on, or topical imidacloprid-moxidectin in a 2:2:1 ratio. Both fluralaner formulations were administered once, at the approved dose rate, on day 0. Imidacloprid-moxidectin was administered per label on day 0, and every 4 weeks, more frequently if necessary. At each visit (days 0, 28, 56, 84), dogs were monitored for demodectic mites, using deep skin scrapings, and observed for health and for severity of skin lesions. Treatment was considered efficacious if more than 90% of the dogs were free of live mites at both days 56 and 84. Results : Of 124 dogs completing the study, 57 were diagnosed with juvenile-onset demodicosis and 67 with the adult-onset form. A single treatment with oral or spot-on fluralaner was efficacious, each eliminating mites from at least 98.0% of treated dogs on days 56 and 84. Against juvenile-onset demodicosis, efficacy of the oral and spot-on formulations was 96.0% and 100%, respectively, and against adult-onset demodicosis 100% and 96.7%. Multiple administrations of imidacloprid-moxidectin were not efficacious, eliminating mites from 87.5% of dogs (92.0% with juvenile-onset demodicosis cured; 81.8% with adult-onset demodicosis). All groups showed a marked reduction in skin lesions by day 28, with continuing clinical improvement at each subsequent visit through day 84. There were no treatment-related adverse events. Conclusion : A single administration of fluralaner chewables or fluralaner spot-on is highly effective against juvenile-onset and adult-onset forms of generalized canine demodicosis. Topically applied imidacloprid-moxidectin at weekly to monthly intervals over the 84-day study did not achieve the proportion of mite-free dogs required to demonstrate efficacy.

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Section: Discussionsupporting

confidence: 84%

“…mites, based on deep skin scrapings, and resolution of clinical signs. A non-blinded, uncontrolled, open-label study with orally administered uralaner provided evidence that those laboratory results could translate into eld e cacy [10,16,17].…”

Section: Introductionmentioning

confidence: 99%

A European Field Assessment of the efficacy of fluralaner (Bravecto®) chewable and spot-on formulations for treatment of dogs with generalized demodicosis

Petersen

Chiummo

Zschiesche

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Results from this controlled field study confirm results from a recent uncontrolled field study in which parasitological cures were observed over three months after fluralaner treatment in all dogs presented with juvenile-onset demodicosis [19]. Fluralaner treatment was also effective in dogs with adult onset demodicosis one month following a second treatment, administered 12 weeks after the first.…”

Section: Discussionsupporting

confidence: 83%

A European Field Assessment of the efficacy of fluralaner (Bravecto®) chewable and spot-on formulations for treatment of client-owned dogs with generalized demodicosis

Petersen

Chiummo

Zschiesche

et al. 2019

Preprint

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Background: Generalized canine demodicosis is unlikely to resolve without therapy and has been traditionally difficult to cure, however there are recent reports of isoxazoline compounds providing safe and effective treatment. This field study compared the efficacy of either oral or topically administered of fluralaner, an isoxazoline, with multiple topical treatments (as often as weekly) with imidacloprid-moxidectin for the treatment of naturally infested dogs with generalized demodicosis.Methods: This study in 5 European countries included 134 dogs randomized for treatment with either fluralaner chewable tablets, fluralaner spot-on, or topical imidacloprid-moxidectin. Both fluralaner formulations were administered once at the approved dose on day 0, while imidacloprid-moxidectin was administered at the approved dose once every 4 weeks or more frequently if necessary. Dogs were monitored for mites, using deep skin scrapings, and clinical signs prior to treatment on day 0, and then on approximately 28, 56 and 84 days after initial treatment. Treatment was considered efficacious if more than 90% of the dogs were free of live mites at days 56 and 84.Results: Treatment with topical or oral fluralaner was 98.0% effective while imidacloprid-moxidectin treatment was 87.5% effective. All groups showed a marked reduction in skin lesions by day 28, with continuing improvement at each subsequent visit through the final assessment on day 84. There were no treatment-related adverse events. Conclusion:Fluralaner chewable tablets and fluralaner spot-on are highly effective for treating dogs affected with generalized canine demodicosis following a single administration. Topical imidaclopridmoxidectin at weekly to monthly intervals did not achieve the mite-free levels required for adequate efficacy over the 12 weeks study period.

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“…The efficacy of the treatment of demodicosis with isoxazolines has been described (Six et al, 2016;Snyder et al, 2017;Lebon et al, 2018). The oral treatment of this disease with fluralaner was effective as observed by other authors (Fourie et al, 2015;Bezerra et al, 2017;Duangkaew et al, 2018) with a single-dose administration. All the dogs obtained negative deep skin scrapings.…”

Section: Discussionmentioning

confidence: 63%

“…This compound was successfully used in parasitic skin diseases as miticidal therapy for sarcoptic mange (Romero et al, 2016) and demodicosis (Fourie et al, 2015;Duangkaew et al, 2018). Against generalized demodicosis, its administration resulted in 99.8% reduction of the mean mite observed by skin scrapings 28 days after treatment, while a 100% reduction was observed in 56 days after treatment (Fourie et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Efficacy of fluralaner against canine generalized demodicosis

et al. 2019

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A field trial in Thailand of the efficacy of oral fluralaner for the treatment of dogs with generalized demodicosis

Abstract: Fluralaner given at the label dose for flea and tick prevention is effective for the treatment of canine generalized demodicosis.

Cited by 22 publications

References 9 publications

A European Field Assessment of the efficacy of fluralaner (Bravecto®) chewable and spot-on formulations for treatment of dogs with generalized demodicosis

A European Field Assessment of the efficacy of fluralaner (Bravecto®) chewable and spot-on formulations for treatment of dogs with generalized demodicosis

A European Field Assessment of the efficacy of fluralaner (Bravecto®) chewable and spot-on formulations for treatment of client-owned dogs with generalized demodicosis

Efficacy of fluralaner against canine generalized demodicosis

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