A field trial of the heat resistant V4 vaccine against Newcastle disease by eye-drop inoculation in village poultry in Cameroon

Bell, J.G.; Fotzo, T.M.; Amara, Abdelkader; Agbede, G.

doi:10.1016/0167-5877(95)00494-7

Cited by 12 publications

(5 citation statements)

References 6 publications

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“…However, it was observed that some birds with low or undetectable ND HI antibody titres survived after challenge. This observation has been reported by Ibrahim et al (1981) who concluded that low HI antibody titre following NDV4 vaccination were not indicative of susceptibility to challenge, an observation also confirmed by other researchers (Bell et al, 1995;Wambura et al, 2000;Tu et al, 1998). In addition to serum antibody, secretory antibody (IgA) at mucosal surfaces and cell mediated immunity are thought to play a role in resistance to challenge (Alexander, 2003).…”

Section: Discussionsupporting

confidence: 68%

Newcastle disease virus antibody in serum and feather pulp of chickens vaccinated with thermostable vaccine coated on grains and brans in Zaria, Northern Nigeria

Abah¹,

Ayuba²,

Adamu³

2017

J. Vet. Med. Anim. Health

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Thermostable Newcastle disease vaccine virus strain I2 (NDVI 2 ) was investigated for its efficacy as foodborne vaccine using maize, sorghum and their brans as carriers. Immune response to vaccination and resistance to challenge were assessed by haemagglutination inhibition (HI) test. After primary and secondary vaccination at three and six weeks of age, sera and feather pulp samples were analyzed to determine the antibody titre in the different groups. The highest mean antibody titre of 7.39 ± 0.42 log 2 was recorded for serum when the vaccine was administered through treated sorghum coated with gum Arabic (TSGG) and 7.28 ± 0.37 log 2 for feather pulp in the group given maize bran (MZB) at eight weeks of age. There was no significant difference (p ˃ 0.05) between the HI antibody titre in the feed groups from feather pulp samples at three weeks of age while a significant difference (p < 0.05) in the serum antibody titre was observed between all the feed groups at five weeks of age. There was correlation in antibody titre between serum and feather pulps only at two weeks after second vaccination. The protection rate after challenge in all the groups was low with the highest rate (14%) recorded when the vaccine was administered in treated maize (TMZ) and TSGG. The study concluded that the vaccine could be effective for the protection of village chickens as food-borne vaccine provided the carrier foods are adequately treated to remove antiviral agents. The use of feather samples as suitable alternative to serum for ND serology was discussed.

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Section: Discussionsupporting

confidence: 68%

Newcastle disease virus antibody in serum and feather pulp of chickens vaccinated with thermostable vaccine coated on grains and brans in Zaria, Northern Nigeria

Abah¹,

Ayuba²,

Adamu³

2017

J. Vet. Med. Anim. Health

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“…This shows that smallholder farmers can choose among the methods of vaccination that suits their particular farming systems and needs. Elsewhere, it was shown that chickens vaccinated via oral route elicited good protection level even though booster vaccination was needed 2–4 weeks later [ 6 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of spray and oral delivery of Newcastle disease I2 vaccine in chicken reared by smallholder farmers in central Ethiopia

et al. 2018

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BackgroundNewcastle disease (ND) is a highly infectious disease causing considerable economic losses to poultry farmers worldwide. Conventional vaccine delivery methods are not suitable for smallholder and rural poultry producers, and thus appropriate vaccination methods need to be sought. This study was carried out with the main objective of evaluating the efficacy of ND I2 vaccine delivered via drinking water and spray under smallholder farmers’ condition in Minjar-Shenkora district, central Ethiopia. Twenty households were randomly assigned to intervention and control groups. Chickens owned by the selected households were randomly assigned to one of the three intervention groups. Blood samples were collected regularly for antibody assay from individual chicken vaccinated with ND I2 vaccine using different routes.ResultsAt baseline, there was no difference in antibody titer among the experimental groups. After the first and booster vaccinations, the three vaccinated groups had significantly higher antibody titer (P < 0.001) than the unvaccinated control group. Interestingly, there was no statistically significant difference in antibody titer among the vaccinated groups. Out of the 40 chicken in the unvaccinated control only 14 had antibody titter≥ log23. Similarly 19/37 of chicken in the drinking water group, 19/37 of chicken in the eye drop group and 20/40 chicken in the spray group had antibody titer ≥ log23. Two weeks after the first vaccination the proportion of chicken with antibody titer ≥ log23 rose to 23/37, 30/37 and 29/40 in the group vaccinated via drinking water, eye drop and spray, respectively. The proportion remained low in unvaccinated group. Hundred percent of the vaccinated chicken survived after infection with the virulent ND virus (Alemaya strain); whereas only 40% survived from the unvaccinated control group.ConclusionThe results of this study showed that ND I2 vaccine administered via drinking water and spray under smallholder farmers’ situation provoked protective antibody level similar to the eye drop method. The use of ND I2 vaccine could contribute to food security if used by rural poultry farmers properly.

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“…Even though this vaccine is administered to individual birds through intramuscular or subcutaneous injection, it seems to still occupy a privileged position in this region despite the existence of more easily administered equivalents through the oral route that have been tested and are in use in other parts of the world (Bell et al 1995;Nguyen-Ba-Vy 1994;Tu et al 1998;Wambura et al 2000). The objectives of this study were to sensitise farmers on the importance of vaccination against ND through demonstration trials and to determine conditions under which a less intensive sustainable vaccination programme could be developed.…”

Section: Introductionmentioning

confidence: 94%

The potential role of an inactivated thermostable vaccine in the control of Newcastle disease in traditionally free-roaming poultry in Central and West Africa

Awa

Tama

Njoya

et al. 2008

Trop Anim Health Prod

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In spite of the clinical and economic importance of Newcastle disease (ND), vaccination of traditional poultry flocks is not a common practice in Cameroon and other countries in West and Central Africa. This study was designed to demonstrate the importance of vaccination against ND and to propose a sustainable vaccination programme with a LaSota strain of NDV vaccine (Multivax) produced in Cameroon. It consisted of field vaccination trials, determination of a strategic vaccination programme through sero-monitoring and assessing vaccine keeping quality under field conditions. Twelve months monitoring of vaccinated flocks revealed that the epidemic periods of March-April and December-January passed without major incidence in flocks. Mortalities were reduced from above 90% in previous years to 10.8% and 24.6% in two experimental sites respectively. Vaccination antibodies were sustained above protection threshold for about 80 days. A booster administered 35 days after the priming dose did not have any effect on declining serum antibodies. The vaccine remained efficacious in eliciting antibody production for up to 10 weeks after initial use and kept at ambient temperature averaging 34 degrees C. For good protection in a less intense vaccination programme, it would be necessary to administer the vaccine one month to the anticipated month of epidemic, thus requiring at least two campaigns per year.

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A field trial of the heat resistant V4 vaccine against Newcastle disease by eye-drop inoculation in village poultry in Cameroon

Cited by 12 publications

References 6 publications

Newcastle disease virus antibody in serum and feather pulp of chickens vaccinated with thermostable vaccine coated on grains and brans in Zaria, Northern Nigeria

Newcastle disease virus antibody in serum and feather pulp of chickens vaccinated with thermostable vaccine coated on grains and brans in Zaria, Northern Nigeria

Evaluation of spray and oral delivery of Newcastle disease I2 vaccine in chicken reared by smallholder farmers in central Ethiopia

The potential role of an inactivated thermostable vaccine in the control of Newcastle disease in traditionally free-roaming poultry in Central and West Africa

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