A fifth subtype of Kaposi's sarcoma, classic Kaposi's sarcoma in men who have sex with men: a cohort study in Paris

Denis, D.; Seta, V.; Régnier‐Rosencher, E.; Kramkimel, N.; Chanal, J.; Avril, Marie-Françoise; Dupin, Nicolas

doi:10.1111/jdv.14831

Cited by 39 publications

(29 citation statements)

References 37 publications

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“…We did not use pathology reports as direct source to collect cases of KS. Recently a fifth type of KS, KS‐CLA affecting men who have sex with men, has been suggested . The sexual preferences of our patients were often lacking, so we cannot conclude on such explanation for KS‐CLA cases in Finland.…”

Section: Discussionmentioning

confidence: 78%

Kaposi sarcoma in Southern Finland (2006–2018)

2019

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Background Kaposi sarcoma (KS) age-standardized incidence rate is below 0.3 per 100,000 in Nordic countries. Data on KS in Finland have been sparse.Methods A retrospective review of all the patients with KS cases managed in the Helsinki University Central Hospital between 2006 and 2018.Results Forty patients (median age at diagnosis 45 years, 38 males) were included. About 2.5 new cases were diagnosed per year (incidence 0.16 /100,000). The different subtypes of KS were: human immunodeficiency virus (HIV) (65%), classical KS (30%), and immunodepression (5%). Patients with HIV were significantly younger, more likely to have cutaneous lesions of the face, the trunk, and mucosal lesions, and KS within lymph nodes and inner organs. KS was diagnosed at the same time as HIV in 77% of cases, 28% with CD4-cell level above 300 cells/mm 3 . Among the patients with classical KS (n = 12), 75%were of Finnish origin, 41% had a second primary malignancy diagnosed, and 25% had noninsulin dependent diabetes mellitus. Among HIV patients, 27% had another AIDSrelated illness, 7% of the patients developed lymphoproliferative disorders, and 7% a hemophagocytic syndrome. Patients with HIV were always treated with antiviral therapy, with pegylated liposomal doxorubicin in 57% of the cases. Local radiotherapy was the main treatment for other KS types. None of the 5 deaths during follow-up was related to KS. ConclusionsClassical KS (KS-CLA) occurs among native Finns, frequently with other present malignancies. Screening of HIV and other malignancies is warranted in new cases of KS. ª

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Section: Discussionmentioning

confidence: 78%

Kaposi sarcoma in Southern Finland (2006–2018)

2019

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“…Non-epidemic KS is a rare, recently identified subtype of KS found in HIV-negative men who engage in sex with other men 10, 11. This subtype has been hypothesized to be related to the high prevalence of HHV-8 in semen and prostate samples 12 …”

Section: Discussionmentioning

confidence: 99%

An unusual series of patients with Kaposi sarcoma

et al. 2019

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“… Non-epidemic KS is a recently introduced category, which affects HIV-negative MSM. This form of KS has a better prognosis, as lesions are often limited [29].…”

Section: Kaposi Sarcomamentioning

confidence: 99%

“…(place for figure3) KS was classified into four clinical-epidemiological forms: classic KS, endemic KS, epidemic KS (or AIDS-associated KS) and iatrogenic KS. A fifth form called non-epidemic KS has recently been added[29].…”

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confidence: 99%

Update on Kaposi sarcoma-associated herpesvirus (KSHV or HHV8) – review

Iftode

Rădulescu

Aramă

et al. 2020

Romanian Journal of Internal Medicine

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Human herpesvirus 8, also known as Kaposi sarcoma-associated herpesvirus (KSHV), is one of the few pathogens recognized as direct carcinogen, being involved in the pathogenesis of Kaposi sarcoma, primary effusion lymphoma and multicentric Castleman disease. KSHV is a relatively recently discovered virus, with still limited possibilities for diagnosis and treatment. Therefore, ongoing studies are trying to answer the main issues related to the management of KSHV infection and its associated diseases. This review updates the current knowledge of the KSHV infection, discussing aspects related to epidemiology, virological features, clinical manifestations, diagnosis and treatment.

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A fifth subtype of Kaposi's sarcoma, classic Kaposi's sarcoma in men who have sex with men: a cohort study in Paris

Abstract: First CKS cohort in low-endemic zone. We describe a fifth subtype of KS: KS in MSM. The CD4 T-cell count was found to correlate with prognosis.

Cited by 39 publications

References 37 publications

Kaposi sarcoma in Southern Finland (2006–2018)

Kaposi sarcoma in Southern Finland (2006–2018)

An unusual series of patients with Kaposi sarcoma

Update on Kaposi sarcoma-associated herpesvirus (KSHV or HHV8) – review

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