The International Maritime Organization has recently updated the ship emission standards to reduce atmospheric contamination. One technique for reducing emissions involves using liquefied natural gas (LNG). The tanks used for the transport and storage of LNG must have very low thermal expansion and high cryogenic toughness. For excellent cryogenic properties, high-Mn steel with a complete austenitic structure is used to design these tanks. We aim to determine the optimum welding conditions for performing Laser-MIG (Metal Inert Gas) hybrid welding through the MIG leading and laser following processes. A welding speed of 100 cm/min was used for welding a 15 mm thick high-Mn steel plate. The welding performance was evaluated through mechanical property tests (tensile and yield strength, low-temperature impact, hardness) of the welded joints after performing the experiment. As a result, it was confirmed that the tensile strength was slightly less than 818.4 MPa, and the yield strength was 30% higher than base material. The low-temperature impact values were equal to or greater than 58 J at all locations in the weld zone. The hardness test confirmed that the hardness did not exceed 292 HV. The results of this study indicate that it is possible to use laser-MIG hybrid welding on thick high-Mn steel plates.