In magnetic resonance imaging (MRI), three-dimensional linearly varied magnetic field gradients are required in the imaging volume, for the encoding of the spatial information of the imaged object.The gradient magnetic field is generated by gradient coils, whose performance directly affects the final MR image quality. Modern MRI applications demand gradient coils to be designed with higher performance such as a faster slew rate for rapid imaging, and fewer system interactions to ensure distortion-free images.During MR imaging, the gradient coil current switches quickly and the alternating current under a strong magnetic field generates a large Lorentz force, thus increasing the vibrations and noise in the gradient assembly, and the vibrations can also transmit to other components in the system. Moreover, the gradient magnetic field induces eddy currents on the surrounding conductive materials, resulting in further mechanical vibration. The sound pressure level (SPL) of an MRI scanner very commonly exceeds 100 dB, which may be discomforting to patients. Therefore, an effective acoustic noise control is necessary for the MRI operation.This thesis attempts to design a novel gradient coil system in an MRI scanner with a particular focus on the investigation of an acoustic noise control scheme. A brief summary of the thesis work is as follows.(1) Gradient coil design A conventional cylindrical MRI scanner has a long patient bore, which may make some patients uneasy due to claustrophobia. In order to alleviate this, an asymmetric gradient coil was proposed to accommodate an asymmetric MRI magnet. The coil was designed with a number of features, for example, to enable the installation of the shim tray, the coil was configured with one end connected and the other end separated. The electromagnetic and acoustic performances were also improved compared with a conventional non-connected coil system.The stream function approach is commonly used in gradient coil design, but an issue with this design is a connection problem between coil loops. To eliminate the field errors due to the coil connections, this thesis proposed a novel spiral coil design scheme, including both transverse coils and a longitudinal coil. The proposed coil design method was not only able to improve the magnetic II performance of the coil, but also could integrate the cooling system into the coil design using hollow wires in the discrete wire space.Wire spacing is a major engineering problem in gradient coil design. Conventional gradient coils are designed with three primary layers and three shielding layers, and in general, primary transverse coils are located in two layers separated by a very dense wire structure. In this thesis, a novel gradient coil design strategy using a layer-sharing scheme was proposed. This design scheme mutually combined the x and y gradient coil layers, effectively utilizing the unoccupied or sparse coil-layer space. The new method was modelled in the case of an asymmetric head coil design, and enhanced coil performan...