A Finite Element Model Revealing Stress Distribution on Tissue Engineering Scaffold in Perfused Bioreactor

Fan, Jie; Liu, X. Y.; Fan, Yi

doi:10.1007/978-3-642-29305-4_521

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…To avoid idiosyncrasy and identify the most typical behaviors, we created a list of 16 immoral behaviors, 9 moral behaviors based on prior research [10,40,41,45], and general societal concerns regarding online behaviors (see Table 1). Participants were individually tested in the lab.…”

Section: Methodsmentioning

confidence: 99%

“…With the vast popularity of the Internet and social media, moral observer-licensing may become increasingly common in cyberspace. Although cyberspace is often characterized by virtuality and anonymity [38][39][40], it can be seen as an extension of the real world, and thus it encompasses patterns of behavior common in real life [41][42][43][44]. Indeed, some patterns of behavior, including moral observer-licensing, may be even more salient in cyberspace because of its virtuality and anonymity.…”

Section: The Current Researchmentioning

confidence: 99%

“…In Study 1, we aimed to examine whether the phenomenon of moral observer-licensing was present in cyberspace. As cyberspace is an important extension of the real world and plays an increasingly significant role in regulating individuals' sense of self and social behavior [10,41,42,44], we expected to observe moral observer-licensing in this context.…”

Section: Studymentioning

confidence: 99%

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Moral Observer-Licensing in Cyberspace

Ran

Hou

Dong

et al. 2022

Behavioral Sciences

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Moral observer-licensing happens when observers condone actors’ morally questionable conduct due to the actors’ history of moral behaviors. In four studies (N = 808), we investigated this phenomenon in the context of cyberspace and its contributing factors and boundary conditions. The pilot study determined what participants perceived as typically moral and immoral behaviors in cyberspace. Then, in Study 1, participants condemned a story character’s online immoral behavior less often when they were informed of the character’s prior online moral behavior than when they were not, which indicates moral observer-licensing in cyberspace. Study 2 confirmed the presence of moral observer-licensing in cyberspace and further demonstrated that a character’s prior moral or immoral behavior online respectively reduces or intensifies the perceived negativity of the character’s subsequent immoral behavior. Finally, Study 3 showed that participants who identified with the victim in a hypothetical scenario showed less forgiveness and more condemnation of a character’s immoral behavior than those who identified with the perpetrator or the bystander. These findings are of theoretical and practical significance for our understanding of cyber ethics.

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Section: Methodsmentioning

confidence: 99%

Section: The Current Researchmentioning

confidence: 99%

Section: Studymentioning

confidence: 99%

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Moral Observer-Licensing in Cyberspace

Ran

Hou

Dong

et al. 2022

Behavioral Sciences

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A review on the use of computational methods to characterize, design, and optimize tissue engineering scaffolds, with a potential in 3D printing fabrication

et al. 2018

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The design and fabrication of tissue engineering scaffolds is a highly complex process. In order to provide a proper architecture for cells to grow, proliferate, and differentiate to form tissues, scaffolds have to be made with suitable properties. However, the limited structural designs and conventional fabrication techniques severely cripple the improvement of scaffold properties. To overcome these limitations, many researchers have recently adopted computational methods combined with 3D printing techniques as a new approach for scaffold design and fabrication. This approach allows scaffolds to be designed and fabricated with highly complex microstructures and good control and accuracy. Previous works have also shown this approach to be a very useful tool to predict the scaffold properties and to optimize the scaffold designs with a great reduction of experimental iterations. As this approach combining computational methods and 3D printing techniques for scaffold design and fabrication has many advantages over the conventional trial‐and‐error based approach, it is imperative to provide a state‐of‐the‐art review on the topic. To this end, this article reviews the various applications of computational methods in scaffold design and simulation; it also briefly reviews the application of 3D printing techniques to fabricate the computationally designed scaffolds. Finally, the limitations and future trends of this approach are discussed. Overall, this review will enable readers to understand the benefits of using computational methods coupled with 3D printing to design and fabricate scaffolds, and thus help researchers to improve and optimize the scaffold properties for future tissue engineering research. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 1329–1351, 2019.

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Geometrical and mechanical analysis of polylactic acid and polyvinylidine fluoride scaffolds for bone tissue engineering

Akbari,

Khazaeinejad

2023

Engineering with Computers

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Utilising finite element analyses and experimental testing, this study investigates the influence of scaffold porosity on mechanical behaviour and evaluates the potential of polylactic acid (PLA) and polyvinylidine fluoride (PVDF) as bone substitute materials. Scaffold geometries were devised using design parameters adapted from extant literature and then generated using computer-aided engineering tools. Methodical variations in strand thickness were applied, maintaining other design criteria constant for robust analysis. Results, derived under varied loading conditions, suggest that scaffold mechanical properties are influenced significantly by geometry, strand diameter and porosity. Cubic scaffolds exhibited marked strength. Structures with reduced porosity demonstrated heightened mechanical characteristics, while facilitating bone cell proliferation. For a comparative context, PVDF scaffolds were benchmarked against human femur bone properties, revealing a mechanical behaviour alignment, particularly in their Young’s modulus.

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A Finite Element Model Revealing Stress Distribution on Tissue Engineering Scaffold in Perfused Bioreactor

Cited by 3 publications

References 9 publications

Moral Observer-Licensing in Cyberspace

Moral Observer-Licensing in Cyberspace

A review on the use of computational methods to characterize, design, and optimize tissue engineering scaffolds, with a potential in 3D printing fabrication

Geometrical and mechanical analysis of polylactic acid and polyvinylidine fluoride scaffolds for bone tissue engineering

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