A Finite Element Study on Variations in Mass Transport in Stented Porcine Coronary Arteries Based on Location in the Coronary Arterial Tree

Keyes, Joseph T.; Simon, B. R.; Geest, Jonathan P. Vande

doi:10.1115/1.4024137

Cited by 3 publications

(2 citation statements)

References 49 publications

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“…This is supported by our findings that demonstrate drug transport and mechanical properties of the porcine coronary arteries vary as a function of vessel and location. [6][7][8] However, currently, there is no ideal imaging modality to monitor and quantify drug delivery to the coronary artery with sub-mm precision.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5] We hypothesize that these failures would be minimized by evaluating in situ coronary artery drug delivery. [6][7][8][9][10][11][12][13][14] Restenosis was minimized by improving drug retention and transport in the coronary artery. Drug delivery to the tunica media has reduced or prevented migration and proliferation of vascular smooth muscle cells that cause restenosis.…”

Section: Introductionmentioning

confidence: 99%

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Tracking delivery of a drug surrogate in the porcine heart using photoacoustic imaging and spectroscopy

2017

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, "Tracking delivery of a drug surrogate in the porcine heart using photoacoustic imaging and spectroscopy," J. Biomed. Opt. 22(4), 041016 (2017), doi: 10.1117/1.JBO.22.4.041016. Abstract. Although the drug-eluting stent (DES) has dramatically reduced the rate of coronary restenosis, it still occurs in up to 20% of patients with a DES. Monitoring drug delivery could be one way to decrease restenosis rates. We demonstrate real-time photoacoustic imaging and spectroscopy (PAIS) using a wavelength-tunable visible laser and clinical ultrasound scanner to track cardiac drug delivery. The photoacoustic signal was initially calibrated using porcine myocardial samples soaked with a known concentration of a drug surrogate (DiI). Next, an in situ coronary artery was perfused with DiI for 20 min and imaged to monitor dye transport in the tissue. Finally, a partially DiI-coated stent was inserted into the porcine brachiocephalic trunk for imaging. The photoacoustic signal was proportional to the DiI concentration between 2.4 and 120 μg∕ml, and the dye was detected over 1.5 mm from the targeted coronary vessel. Photoacoustic imaging was also able to differentiate the DiI-coated portion of the stent from the uncoated region. These results suggest that PAIS can track drug delivery to cardiac tissue and detect drugs loaded onto a stent with sub-mm precision. Future work using PAIS may help improve DES design and reduce the probability of restenosis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tracking delivery of a drug surrogate in the porcine heart using photoacoustic imaging and spectroscopy

2017

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Study on the Impact of Straight Stents on Arteries With Different Curvatures

Wei

Chen

2016

J. Mech. Med. Biol.

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Different stent structures lead to different deformations of blood vessels, such as different cross-sectional shapes, which further influence the blood flow patterns. In this paper, six non-commercial stents with different link structures called I-, C-, S-, U-, N- and W-types were considered. Their influences on arteries with five different curvatures (i.e., 0[Formula: see text], 15[Formula: see text], 30[Formula: see text], 45[Formula: see text] and 60[Formula: see text]) were studied using finite element method. Four indices including the maximum plastic strain of stents, the rate of expansion, the maximum von Mises stress and the ellipticity of arteries, were compared for all cases. The results showed that the S-type or U-type stents, with larger plastic strain and lower von Mises stress on the arteries, provided the optimal outcome. As the link structures became complex, the arterial expansion increased monotonically, while the ellipticity of arteries showed a decreasing tendency in the vessel models. The present study could be useful for the commercial design and clinic selection of a stent with different link structures for different curved arteries.

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Numerical Investigation on Influence of Vascular Stenosis Rate and Curvature Radius on Plaque Vulnerability in Stented Vessels

Jiang

Liu

et al. 2020

J. Mech. Med. Biol.

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The high stresses on plaque wall experienced by stent implantation into a stenotic artery can go beyond the material strength of plaque tissue, potentially leading to plaque rupture. Two non-commercial stents with different link structures called S-type and N-type were taken into account, respectively. A non-linear finite element model was developed to investigate the influence of the stenosis level (i.e., 24%, 40%, and 50%) and arterial curvature radius (i.e., 6, 10, and 20[Formula: see text]mm) on the stress induced within the plaque tissue during stent expansion. The numerical results indicated that the severer stenosis level and more tortuous artery caused the higher stress on plaque wall. The maximal stresses on the plaque wall were in the fracture level of 1.79[Formula: see text]MPa for N-type stent, and 1.82[Formula: see text]MPa for S-type stent under the 50% stenosis rate and 6[Formula: see text]mm curvature radius. Due to smaller compliance mismatch to the curved vessel, the N-type stent was founded to induce less stress gradient on the plaque wall than that by the S-type stent. This suggests a lower risk of the plaque rupture for the N-type stent. This study showed how the arterial curvature radius and stenosis level were correlated with the plaque vulnerability. Therefore, it is possible to choose a suitable stent in terms of arterial stenosis geometry and thereby optimize the outcome of stenting procedure.

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A Finite Element Study on Variations in Mass Transport in Stented Porcine Coronary Arteries Based on Location in the Coronary Arterial Tree

Cited by 3 publications

References 49 publications

Tracking delivery of a drug surrogate in the porcine heart using photoacoustic imaging and spectroscopy

Tracking delivery of a drug surrogate in the porcine heart using photoacoustic imaging and spectroscopy

Study on the Impact of Straight Stents on Arteries With Different Curvatures

Numerical Investigation on Influence of Vascular Stenosis Rate and Curvature Radius on Plaque Vulnerability in Stented Vessels

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