A first case report of nasopharyngeal Mycobacterium abscessus subspecies massiliense infection

Oki, Yamato; Hatakeyama, Hyōe; Komatsu, Masanori; Isono, Yasuhiro; Ikemiyagi, Hidetaka; Tsukiji, Jun; Higa, Ryoko

doi:10.1186/s40001-021-00578-8

Cited by 2 publications

(5 citation statements)

References 30 publications

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“…Of the three patients with pharyngeal infection, our patient and that reported by Oki et al 12 had a history of physical irritation of the pharynx caused by nasal irrigation and nasopharyngeal abrasive therapy, respectively. Among the five patients with laryngeal lesions only, four had a history of steroid therapy, and two were administered with inhaled steroids.…”

Section: Discussionmentioning

confidence: 59%

“… 5 Oki et al reported a case of M. abscessus nasopharyngitis resulting from the transmission of bacteria from contaminated medical devices that were only washed with tap water, which had been used during repeat nasopharyngeal abrasive therapy for pharyngitis. 12 Our patient had no history of dental or otolaryngological treatments.…”

Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

“…6,9 Infections of the upper respiratory tract, such as those of the pharynx, rarely occur, with sinusitis being the most common type of upper respiratory tract infection caused by NTM. 10,11 Moreover, the only types of pharyngeal NTM infection identified were nasopharyngitis, reported by Oki et al, 12 and hypopharyngitis/laryngitis, reported by Hussin et al 13 The M. abscessus complex is resistant to disinfectants used to minimize the risk of infection during surgery and other procedures. Therefore, they can cause postsurgical and postprocedural infections.…”

Section: Discussionmentioning

confidence: 99%

“…This condition is rare, with only eight cases reported to date, including the case reported here. Of the seven other cases, one involved infection of the pharynx alone, 12 one involved infection of both the pharynx and larynx, 13 and five involved infection of the larynx alone. [15][16][17][18][19] All patients were female, had a median age of 45 years (range: 30-81 years), and only two showed abnormal findings on chest CT.…”

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confidence: 98%

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Nasopharyngeal Mycobacterium abscessus Infection: A Case Report and Literature Review

Kaji¹,

Namkoong²,

Nagao³

et al. 2023

IDR

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Background Mycobacterium abscessus ( M. abscessus ) is a rapidly growing bacterium (RGM) that causes refractory pulmonary and extrapulmonary infections. However, studies investigating pharyngeal and laryngeal M. abscessus infections are limited. Case Presentation A 41-year-old immunocompetent woman complaining of bloody sputum was referred to our hospital. Although her sputum culture tested positive for M. abscessus subsp. abscessus , radiological findings were not indicative of pulmonary infection or sinusitis. Further diagnostic workup, including laryngeal endoscopy and positron emission tomography/computed tomography (PET/CT), confirmed the presence of nasopharyngeal M. abscessus infection. The patient was initially treated with intravenous amikacin, imipenem/cilastatin, azithromycin, and clofazimine for 28 days, after which the patient was provided with amikacin, azithromycin, clofazimine, and sitafloxacin for four months. After the completion of antibiotic therapy, the patient showed negative results on sputum smear and culture and normal findings on PET/CT and laryngeal endoscopy. Whole-genome sequencing of this strain revealed that it belonged to the ABS-GL4 cluster, which has a functional erythromycin ribosomal methylase gene, although it is not a major lineage in non-cystic fibrosis (CF) patients in Japan and Taiwan and in CF patients in European countries. We conducted a literature review and identified seven patients who developed pharyngeal/laryngeal non-tuberculous mycobacterium (NTM) infection. Four of the eight patients had a history of immunosuppressant use, including steroids. Seven of the eight patients responded well to their treatment regimens. Conclusion Patients whose sputum culture tests are positive for NTM and who meet the diagnostic criteria for NTM infection but do not have intrapulmonary lesions should be evaluated for otorhinolaryngological infections. Our case series revealed that immunosuppressant use is a risk factor for pharyngeal/laryngeal NTM infection and that patients with pharyngeal/laryngeal NTM infections respond relatively well to antibiotic therapy.

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 98%

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Nasopharyngeal Mycobacterium abscessus Infection: A Case Report and Literature Review

Kaji¹,

Namkoong²,

Nagao³

et al. 2023

IDR

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Concomitant Nasopharyngeal and Otomastoid Tuberculosis: a Report of 3 Cases and a Review of Literature

Zhu,

Xu,

Dong

et al. 2024

Ear Nose Throat J

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Objective: Concomitant nasopharyngeal and otomastoid tuberculosis (TB) is an extremely rare clinical condition. So far, there have only been 2 such cases reported in English literature, and another 2 such cases have been reported in Chinese literature. The objective of this work is to summarize our experience dealing with this condition and to review the literature. Methods: A retrospective review of cases with concomitant nasopharyngeal and otomastoid TB treated at 2 tertiary medical institutions between June 2022 and May 2024 was undertaken. Data were retrieved from case notes and analyzed. Results: In total, 3 cases were included (2 male patients were from the former institution, and 1 female patient was from the latter). One case was bilateral, and the other 2 cases were unilateral. Their age was between 23 years old and 49 years old (average and median age was 36.3 and 37 years old, respectively). Presenting symptoms included ear fullness, hearing loss, otorrhea, facial paralysis, and otalgia. Careful diagnostic work-up led to the discovery of both otomastoid and nasopharyngeal lesions in all patients. Surgical procedures were planned, and histopathological examination of lesions of both sites was suggestive of TB for all cases, while polymerase chain reaction (PCR) confirmed the presence of Mycobacterium tuberculosis. All patients were subjected to 6 months of anti-TB treatment. The median duration of follow-up was 10 months. No recurrence was documented. A summary of all 7 such cases was also presented. Conclusions: Concomitant nasopharyngeal and otomastoid tuberculosis is very rarely encountered. Surgery or surgical biopsy is important for both treatment and diagnosis. After confirmation of TB by histopathology and PCR, anti-TB treatment is very important for the prevention of recurrence. Symptoms could generally be improved, although not always optimistic.

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A first case report of nasopharyngeal Mycobacterium abscessus subspecies massiliense infection

Cited by 2 publications

References 30 publications

Nasopharyngeal Mycobacterium abscessus Infection: A Case Report and Literature Review

Nasopharyngeal Mycobacterium abscessus Infection: A Case Report and Literature Review

Concomitant Nasopharyngeal and Otomastoid Tuberculosis: a Report of 3 Cases and a Review of Literature

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