A First-Degree Relative With Diabetes Mellitus Is an Important Risk Factor for Rural Thai Villagers to Develop Type 2 Diabetes Mellitus

Muktabhant, Benja; Sanchaisuriya, Pattara; Trakulwong, Mantana; Mingchai, Rumpai; Schelp, Frank Peter

doi:10.1177/1010539514555861

Cited by 11 publications

(7 citation statements)

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“…The association of DM knowledge with academic status may reflect that study participants with better education may have better chance to read information regarding about DM. Such individuals also have more possibilities to communicate with appropriate health personnel and know more about the disease [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…Inheritance of T1DM may reach up to 30% [ 8 ]. In addition, having a first-degree relative with DM is considered an important risk factor to develop T2DM, due to inheritance of genetic risk factors and/or a similar life style pattern among family members [ 9 ]. Environmental factors such as over-nutrition and obesity, and life style changes due to increased urbanization and hygiene may also add to the risk of developing T2DM in Ethiopia.…”

Section: Introductionmentioning

confidence: 99%

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Knowledge and practice on prevention of diabetes mellitus among Diabetes mellitus family members, in suburban cities in Ethiopia

et al. 2017

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BackgroundDiabetes mellitus (DM) is one of the serious non communicable diseases worldwide. Presence of DM patient in a family may be considered as risk factor for other family members to acquire the disease, due to DM inheritance nature and/or similar life style pattern among family members. This paper assessed awareness of DM patients’ family members (DMPFMs) about DM occurrence and prevention. A cross sectional study was conducted in 2014 in two suburban cities of Ethiopia, namely Kemisse, and Kombolcha using an interviewer administered questionnaire among primary or secondary degree DMPFMs and controls. Based on eligibility criteria study participants were selected by health extension workers on house to house visit. Data were analyzed using SPSS version 20, and P value less than 0.05 considered as statistically significant.ResultsOf the total 347 study participants, 45.5% (n = 158) had DMPFMs. Majority, 60.8% of DMPFMs and 73.0% of controls were males. Mean age of DMPFMs (30.06 years) was less than that of the controls (37.38 years). On living style, 51.9% DMPFMs, and 42.8% of controls were single. In both study groups, the majority of study participants attended grade 7–12. The likelihood of having good level of knowledge among DMPFMs were 2.94 times (AOR = 2.94 95% CI 1.87–4.86) higher compared to those who did not. Those attaining higher educational levels were 3.41 times (AOR = 3.41, 95% CI 1.31–8.91) more likely to have good level of knowledge, as compared to those who were unable to read and write. The likelihood of having good level of positive practice among DMPFMs were 3.38 times (AOR = 3.38% CI 2.05–5.58) higher as compared to controls. Participants who were living in Kombolcha were 2.33 times (AOR = 2.33 95% CI 1.31–4.12) more likely to have good level of practice, as compared to individuals from Kemisse.ConclusionsDiabetes mellitus family members in the Ethiopian suburban cities Kemisse, and Kombolcha had better knowledge and practice about DM compared to controls. But, the overall awareness about DM occurrence and prevention was relatively low. Thus, DM awareness campaigns should be strongly pursued regardless of family history and educational background to prevent further increase of DM in Ethiopia.Electronic supplementary materialThe online version of this article (10.1186/s13104-017-2871-7) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Knowledge and practice on prevention of diabetes mellitus among Diabetes mellitus family members, in suburban cities in Ethiopia

et al. 2017

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“…Unlike diabetic patients, FDRs of diabetic patients do not display with signs of symptoms and their risk factors are often overlooked. Typical metabolic syndrome alterations have been reported at an early age, including central obesity, dyslipidemia, glucose intolerance, and high blood pressure [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of triglycerides and waist circumference on insulin resistance and β-cell function in non-diabetic first-degree relatives of type 2 diabetes

et al. 2021

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Background Although there is abundant evidence indicating the relative contribution of insulin resistance (HOMA-IR) and β-cell dysfunction (HOMA-β) among first-degree relatives (FDRs) of Type 2 DM patients, few studies reported the association between HOMA-IR and HOMA-β with metabolic syndrome. Our objective was to evaluate the impact of metabolic syndrome factors on HOMA-IR, HOMA-β and glycoproteins in non-diabetic FDRs. Methods In this study, 103 Yemeni male subjects aged 25–42 years, with BMI < 25 kg/m2 were examined, 39 of whom were normal subjects with no family history of diabetes served as control and 64 subjects were non-diabetic FDRs of Type 2 DM patients. Results Both glycoproteins, glycated haemoglobin (HbA1c) and fructosamine as well as insulin, HOMA-IR and HOMA-β were significantly (p = 4.9 × 10−9; 6.0 × 10−8; 6.6 × 10−12; 1.3 × 10−7; 5.5 × 10−12, respectively) higher in non-diabetic FDRs as compared to control group. Fasting plasma glucose, though within normal range, were significantly (p = 0.026) higher in non-diabetic FDRs. Linear regression analysis showed that both TG and WC are the main metabolic syndrome factors that significantly increased HOMA-IR (B = 0.334, p = 1.97 × 10−6; B = 0.024, p = 1.05 × 10−5), HOMA-β (B = 16.8, p = 6.8 × 10−5; B = 0.95, p = 0.004), insulin (B = 16.5, p = 1.2 × 10−6; B = 1.19, p = 8.3 × 10−6) and HbA1c (B = 0.001, p = 0.034; B = 0.007, p = 0.037). Conclusion Triglyceride and WC are the important metabolic syndrome factors associated with insulin resistance, basal β-cell function and insulin levels in non-diabetic FDR men of Type 2 DM patients. Moreover, FDRs showed insulin resistance with compensatory β-cell function (hyperinsulinaemia) suggesting that insulin resistance precede the development of pancreatic β-cell dysfunction in individuals at risk of Type 2 DM.

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“…8 In addition; having a first-degree relative with DM is considered an important risk factor to develop T2DM, due to inheritance of genetic risk factors and/or a similar life style pattern among family members. 9 Offspring of one parent with type II diabetes mellitus have a two to fourfold increase relative risk of developing the disease 10 equivalent to a 20-40% absolute risk. 11 The risk is even higher if both parents are affected and in some ethnic minority populations.…”

Section: Introductionmentioning

confidence: 99%

Knowledge among Offspring of Type II Diabetic Patients Regarding their Risk of Developing Diabetes and Practices of Preventive Lifestyle

Maawya¹,

Zafar²,

Naeem³

et al. 2021

PJMHS

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Aims: To assess the knowledge of off-springs of diabetic patients regarding, perceived risk of developing type II diabetes &possibilities of its prevention and behaviour of study participants to adopt healthy lifestyle for the prevention of diabetes was also explored. Study Design: Cross sectional study Place and Duration of Study: Department of Medicine, Shaikh Zayed Medical Complex, Lahore and Mayo Hospital Lahore from 1st February 2020 to 31st July 2020. Methodology:Two hundred and fifty individuals were enrolled. A face to face interview of all study participants was conducted and a questionnaire was filled. Results: There were 103(41.2%) had good knowledge regarding various aspects of diabetes, 120(48.0%) and 139(55.6%) had a good understanding of diabetes risk factors and prevention, respectively. It was shown that 74 (29.6%), had a high risk of getting diabetes in the future and only 112 (44.8%) of the individuals had strong diabetes preventive practices. A high score of preventive lifestyle was significantly associated with good level of knowledge of participants regarding diabetes (p=0.0165) and also with patients having great concern about their risk of getting diabetes in future (p=0.0052). Conclusions: People who have one or both parents with type 2 diabetes are typically aware that they have a higher chance of developing diabetes themselves. They, on the other hand, frequently underestimate the danger and have limited knowledge of potentially effective preventative interventions. If they are to decrease their risk of diabetes and its consequences, they need correct knowledge on it. Keywords: Offsprings of diabetics, Prevention of diabetes, Knowledge about diabetes

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A First-Degree Relative With Diabetes Mellitus Is an Important Risk Factor for Rural Thai Villagers to Develop Type 2 Diabetes Mellitus

Cited by 11 publications

References 31 publications

Knowledge and practice on prevention of diabetes mellitus among Diabetes mellitus family members, in suburban cities in Ethiopia

Knowledge and practice on prevention of diabetes mellitus among Diabetes mellitus family members, in suburban cities in Ethiopia

Impact of triglycerides and waist circumference on insulin resistance and β-cell function in non-diabetic first-degree relatives of type 2 diabetes

Knowledge among Offspring of Type II Diabetic Patients Regarding their Risk of Developing Diabetes and Practices of Preventive Lifestyle

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