A First Efficient Voltammetric Approach for Detection of Octreotide, an Octapeptide Analogue of Somatostatin Natural Hormone, in Sandostatin Intramuscular Injection and Human Plasma Based on Modification Free Electrochemical Sensor

El‐Desoky, Hanaa S.; Ghoneim, Mohammed M.; Khattab, Ahmed E.

doi:10.1149/2.0911904jes

Cited by 12 publications

(13 citation statements)

References 59 publications

(123 reference statements)

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“…2,19 Furthermore, carbon paste is prepared from hydrophobic graphite and lipophilic pasting liquid (Nujol oil) which make the bare CPE surface highly hydrophobic. This hydrophobicity facilitates the access of the itraconazole molecules to the electrode surface and its adsorption in the lipophilic layer formed by the organic liquid, 49 and consequently a reasonable electrochemical response was achieved at bare CPE.…”

Section: Resultsmentioning

confidence: 99%

A Simple Approach for Trace Voltammetrical Determination of Itraconazole an Inhibitor of the Cytochrome P-450 14 α-demethylase Enzyme in Formulation and Human Plasma Utilizing Graphene-Carbon Paste Electrode in Situ Modified with an Anionic Surfactant

El‐Desoky

Khattab

2020

J. Electrochem. Soc.

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An economical graphene-carbon paste electrode (GR/CPE) in situ modified with surfactants was used for improvement the sensitivity and selectivity of the electrochemical measurement of itraconazole drug. Among the surfactants, cationic (cetyltrimethyl ammonium bromide, CTAB) and non-ionic (Triton X-100) displayed a decrease in peak current intensity, while anionic (sodium dodecyl sulfate, SDS) exhibited better change in the electrical properties of the electrode-solution interface. The adsorbed-SDS at GR/CPE interacts with itraconazole molecules through hydrophobic and electrostatic attraction which encourages the electron transmission between the drug and electrode surface. Compared with CPE and GR/CPE, SDS-GR/CPE exhibits the enhanced peak current intensity and reduces the over potential toward itraconazole oxidation as a result of the combined effect of GR and SDS. % composition of GR/CPE and SDS concentration were optimized. Wide linear dependence of the current on bulk itraconazole concentration (1.5 × 10 −9 -7.0 × 10 −7 M) was achieved in Britton-Robinson buffer, pH 2.0 containing 0.5 mM SDS at 0.3%(w/w) GR/CPE. SDS-GR/CPE presents adequately LOD value (1.36 × 10 −9 ± 1.07 × 10 −10 M) for the determination of itraconazole in human plasma. SDS-GR/CPE avoids interference from important common substances in biological and pharmaceutical samples. The fabricated sensor has desirable stability and reproducibility that can be used in routine quality control and pharmacokinetic studies.

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Section: Resultsmentioning

confidence: 99%

A Simple Approach for Trace Voltammetrical Determination of Itraconazole an Inhibitor of the Cytochrome P-450 14 α-demethylase Enzyme in Formulation and Human Plasma Utilizing Graphene-Carbon Paste Electrode in Situ Modified with an Anionic Surfactant

El‐Desoky

Khattab

2020

J. Electrochem. Soc.

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“…These methods include high‐performance liquid chromatography, [ 9–11 ] liquid chromatography, [ 12–14 ] electrophoresis, [ 15 ] proton ( 1 H) quantitative nuclear magnetic resonance, [ 16 ] spectrofluorimetry, [ 17 ] and voltammetry. [ 18 ]…”

Section: Introductionmentioning

confidence: 99%

“…These methods include high-performance liquid chromatography, [9][10][11] liquid chromatography, [12][13][14] electrophoresis, [15] proton ( 1 H) quantitative nuclear magnetic resonance, [16] spectrofluorimetry, [17] and voltammetry. [18] Generally, direct spectrofluorimetric methods based primarily on the measurement of the native drug fluorescence are of great interest. [19] As these methods do not require any hazardous solvents that have a high risk to the environment and the health of workers.…”

Section: Introductionmentioning

confidence: 99%

Facile spectrofluorimetric quantitation of octreotide, a synthetic peptide, in its pure form and pharmaceutical formulation; evaluation of the method’s greenness

2022

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A new, rapid, highly sensitive, and affordable spectrofluorimetric approach has been constructed and validated for the determination of octreotide in its authentic form and pharmaceutical dosage form. Octreotide is an important synthetic analog of the naturally occurring somatostatin hormone. The developed spectrofluorimetric approach is actually dependent on the measurement of octreotide native fluorescence at emission wavelength of 342 nm after excitation at 218 nm. At optimal reaction conditions, the calibration curve has been constructed over the concentration range 200–2000 ng ml−1, with excellent linearity. The limits of detection and quantitation values were found to be 55 and 169 ng ml−1, respectively. The developed approach has been effectively used to determine octreotide in its pharmaceutical ampoules, without interference from the excipients in the dosage form. The developed approach is simple, time‐saving, and does not require multiple pretreatment steps for samples, costly apparatus, or dangerous materials. As a result, it can be used to detect and quantify octreotide acetate in quality control laboratories.

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“…37 ZrO 2 shows high ionic conductivity particularly for oxygen ions; hence it is frequently used as oxygen sensors and high temperature fuel cells. [38][39][40] It is commonly used as orthopedic implants due to its key features such as high hardness, strength and biocompatibility. In the present work an important and highly stable metal oxide which is being used for the first time, that is ZNPs were used for the electrochemical detection of 5-HT.…”

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confidence: 99%

Electrochemical Detection of Serotonin Using t-ZrO₂ Nanoparticles Modified Carbon Paste Electrode

Matt

Shivanna²,

Manjunath³

et al. 2020

J. Electrochem. Soc.

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Synthesis of zirconium oxide (zirconia) (ZrO2) nanoparticles (ZNPs) through gel combustion technique as well as their structural and morphological characterization using XRD, SEM and TEM forms the central theme of this work. Along with structural and morphological characterization, an electrochemical detection of Serotonin (5-HT) is described using ZNPs Modified Carbon Paste Electrode (ZMCPE). The XRD results confirms that particles are well crystallized in tetragonal phase with average particle size of 35 nm. From SEM it can be observed that, the materials formed is porous in nature and the particles are seems to be uniform in size. HRTEM reveals that, the particles size in the order of 30–40 nm and the crystallinity was supported by SAED pattern of the ZNPs and these results are in close agreement with the results obtained through XRD. The Electrochemical detection of Serotonin (5-HT) was performed through cyclic voltammetric and differential pulse voltammetric method at different circumstances like concentration of the analyte, applied potentials and pH of the medium. The DPV experiments shows that ZMCPE displays high sensitivity for the quantification of serotonin (5-HT) in the range 10–50 μM and the limit of detection is 0.585 μM. The ZMCPE gives good reproducibility, high catalytic activity and sensitivity for the electrochemical quantification of Serotonin.

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A First Efficient Voltammetric Approach for Detection of Octreotide, an Octapeptide Analogue of Somatostatin Natural Hormone, in Sandostatin Intramuscular Injection and Human Plasma Based on Modification Free Electrochemical Sensor

Cited by 12 publications

References 59 publications

A Simple Approach for Trace Voltammetrical Determination of Itraconazole an Inhibitor of the Cytochrome P-450 14 α-demethylase Enzyme in Formulation and Human Plasma Utilizing Graphene-Carbon Paste Electrode in Situ Modified with an Anionic Surfactant

A Simple Approach for Trace Voltammetrical Determination of Itraconazole an Inhibitor of the Cytochrome P-450 14 α-demethylase Enzyme in Formulation and Human Plasma Utilizing Graphene-Carbon Paste Electrode in Situ Modified with an Anionic Surfactant

Facile spectrofluorimetric quantitation of octreotide, a synthetic peptide, in its pure form and pharmaceutical formulation; evaluation of the method’s greenness

Electrochemical Detection of Serotonin Using t-ZrO₂ Nanoparticles Modified Carbon Paste Electrode

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A First Efficient Voltammetric Approach for Detection of Octreotide, an Octapeptide Analogue of Somatostatin Natural Hormone, in Sandostatin Intramuscular Injection and Human Plasma Based on Modification Free Electrochemical Sensor

Cited by 12 publications

References 59 publications

A Simple Approach for Trace Voltammetrical Determination of Itraconazole an Inhibitor of the Cytochrome P-450 14 α-demethylase Enzyme in Formulation and Human Plasma Utilizing Graphene-Carbon Paste Electrode in Situ Modified with an Anionic Surfactant

A Simple Approach for Trace Voltammetrical Determination of Itraconazole an Inhibitor of the Cytochrome P-450 14 α-demethylase Enzyme in Formulation and Human Plasma Utilizing Graphene-Carbon Paste Electrode in Situ Modified with an Anionic Surfactant

Facile spectrofluorimetric quantitation of octreotide, a synthetic peptide, in its pure form and pharmaceutical formulation; evaluation of the method’s greenness

Electrochemical Detection of Serotonin Using t-ZrO2 Nanoparticles Modified Carbon Paste Electrode

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Electrochemical Detection of Serotonin Using t-ZrO₂ Nanoparticles Modified Carbon Paste Electrode