A five week, polysomnographic assessment of zaleplon 10 mg for the treatment of primary insomnia

Walsh, James K.; Vogel, Gerald W.; Scharf, Martin B.; Erman, Milton K.; Erwin, C. W.; Schweitzer, Paula K.; Mangano, Richard M.; Roth, Thomas

doi:10.1016/s1389-9457(99)00006-4

Cited by 113 publications

(77 citation statements)

References 11 publications

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“…This notion is consistent with the observation that some individuals (~22%) are unable to identify a specific stressor that they believe can account for the onset of their insomnia symptoms [29]. An important result of the present study is that following nocturnal caffeine administration, the vulnerable population had a higher sleep latency (~60 min) than is typically reported for chronic insomniacs [30] and longer than that found in studies using similar doses of caffeine in healthy subjects [27].…”

Section: Discussionsupporting

confidence: 90%

Stress-related sleep disturbance and polysomnographic response to caffeine

et al. 2006

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Background and purpose-To determine the sleep response to caffeine in individuals vulnerable to stress-related sleep disturbance as measured by polysomnography.Patients and methods-Eleven healthy individuals without insomnia scoring low (4 women, mean age=32.64 ± 15.46 years) and 10 healthy individuals also without insomnia scoring high (6 women, mean age=34.20 ± 13.73 years) on a measure of vulnerability to stress-related sleep disturbance were studied in a laboratory protocol. A moderate-low dose of caffeine (3 mg/kg) was administered 1 h prior to lights-out and compared to a counterbalanced control night with each condition separated by 1 week. Standard polysomnographic measures were assessed (i.e. total sleep time, sleep efficiency, latency to persistent sleep, and sleep stage percentages) for both control and caffeine nights.Results-There were no between-group differences in sleep on the control night. Importantly, individuals reporting vulnerability to stress-related sleep disturbance had significantly prolonged latency to persistent sleep in response to the caffeine challenge (interaction; P <0.05).Conclusion-Normal sleepers with an identified vulnerability to stress-induced sleep disturbance exhibited greater objectively verifiable sleep-reactivity in response to a caffeine challenge compared to non-vulnerable individuals. These results suggest that the construct of individual differences in vulnerability to sleep disturbance applies to a pharmacological 'stressor' (i.e. caffeine) as well as to previously assessed stressors such as a first-night effect. This finding provides further support for generalized trait vulnerability by demonstrating a sleep disturbance to a wake-promoting pharmacological challenge in specific a priori identified individuals.

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Section: Discussionsupporting

confidence: 90%

Stress-related sleep disturbance and polysomnographic response to caffeine

et al. 2006

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“…[1][2][3][4][5][6][7][8] This therapy serves as a candidate for a non-drug method for treating patients with sleep disorders. 9,10 The presented results demonstrate a clear difference in the reaction to the treatment of the patients from the two groups. Some qualitative and quantitative characteristics of sleep disorders shows positive dynamics during the AM therapy for the first group of patients.…”

Section: Discussionmentioning

confidence: 67%

“…In the early 1950s, neuroleptics and antihistamines are preferred. 9,10 Since 1960, benzodiazepine hypnotics of the second generation (diazepam and oxazepam) have been used. 9,10 The third generation of hypnotics was developed in [1980][1981][1982][1983][1984][1985][1986][1987][1988][1989][1990], including the derivative of cyclopyrrolane (zopiclone, or imovan) and the imidazopyridine derivative (zolpidem, or ivadal), which had minimal side effects.…”

Section: Introductionmentioning

confidence: 99%

“…9,10 Since 1960, benzodiazepine hypnotics of the second generation (diazepam and oxazepam) have been used. 9,10 The third generation of hypnotics was developed in [1980][1981][1982][1983][1984][1985][1986][1987][1988][1989][1990], including the derivative of cyclopyrrolane (zopiclone, or imovan) and the imidazopyridine derivative (zolpidem, or ivadal), which had minimal side effects. 9,10 A new direction is the use of synthetic 1 It is important to develop non-drug therapies for insomnia, possessing no side effects.…”

Section: Introductionmentioning

confidence: 99%

“…9,10 The third generation of hypnotics was developed in [1980][1981][1982][1983][1984][1985][1986][1987][1988][1989][1990], including the derivative of cyclopyrrolane (zopiclone, or imovan) and the imidazopyridine derivative (zolpidem, or ivadal), which had minimal side effects. 9,10 A new direction is the use of synthetic 1 It is important to develop non-drug therapies for insomnia, possessing no side effects. 13,14 In this work, we study how the natural active energy fields of specialized Bio velocity mattresses influence the quality of sleep.…”

Section: Introductionmentioning

confidence: 99%

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The sleep quality of patients with insomnia under the influence of subtle energy fields

Kryzhanovskii¹,

Yavorsky²,

Choong³

2018

Int J Res Med Sci

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Background: The article evaluates the current state of insomnia treatment for patients without neurological, psychiatric, and somatic disorders. An important goal consists in developing non-drug therapies for insomnia, possessing no side effects. Following this research direction, we put a special emphasis on non-medicamental methods for correction of sleep disturbance in persons with psychophysiological insomnia.Methods: Authors propose a method of insomnia treatment in which patients sleep on the specialized Bio Velocity mattresses (the ‘activated mattress’ therapy). The conditions of patients before and after the treatment are assessed by clinical, psychophysiological, electroencephalographic methods, and by the Voll method, which studies the meridians of organs and systems, including the nervous system.Results: We show the effectiveness of the therapy by demonstrating improving psychological indicators, EEG data, and the Voll diagnostics data in a group of patients.Conclusions: The activated Bio Velocity mattresses can effectively be used by patients with the sleep disorders in addition to and, partially, as a replacement of conventional tools and medicine.

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