A flavanone and a dihydrodibenzoxepin from Bauhinia variegata

Reddy, Mopur Vijaya Bhaskar; Reddy, M. Kesava; Gunasekar, Duvvuru; Caux, Cristelle; Bodo, Bernard

doi:10.1016/s0031-9422(03)00416-3

Cited by 55 publications

(43 citation statements)

References 10 publications

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“…Antiprotozoal, antihelmintic, antitumor, antiulcer and cytotoxic of B. variegata have been reported by CECHINEL FILHO 2 . Flavones and quercetin have been isolated from leaf of B. variegata 17 . Quercetin targets cysteine string proteins (CSPα) and impairs synaptic transmission 37 .…”

Section: Discussionmentioning

confidence: 99%

Characterization of the molluscicidal activity of Bauhinia variegata and Mimusops elengi plant extracts against the fasciola vector lymnaea acuminata

Singh

2012

Rev. Inst. Med. trop. S. Paulo

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Section: Discussionmentioning

confidence: 99%

Characterization of the molluscicidal activity of Bauhinia variegata and Mimusops elengi plant extracts against the fasciola vector lymnaea acuminata

Singh

2012

Rev. Inst. Med. trop. S. Paulo

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“…A chemical survey of the genus afforded mainly glycosil flavonoids (Yadava & Tripathi, 2000), other phenolic derivatives (Reddy et al, 2003) and cyanoglycosides (Fort et al, 2001). The 6,7-dihydroxycoumarin-β-D-glucopyranoside or esculin (coumarin), a main constituent present in the ethanolic extract, aqueous fraction of B. platypetala leaves (Table 1), is well known for its antioxidant activities (Kaneko et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Chemical composition and anxiolytic-like effects of the Bauhinia platypetala

Santos¹,

Lima²,

Cerqueira³

et al. 2012

Rev. bras. farmacogn.

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Abstract:The pantropical genus Bauhinia, Fabaceae, known popularly as cow's foot, is widely used in folk medicine as antidiabetic. Behavioral effects of the ethanolic extract and ethereal, aqueous and ethyl acetate fractions from B. platypetala Benth. ex Hemsl. leaves were studied in male Swiss mice. The ethanolic extract and fractions were administered intraperitoneally and its effects on spontaneous motor activity (total motility, locomotion, rearing and grooming behavior) were monitored. Anxiolytic-like properties were studied in the elevated plus-maze test and the possible antidepressantlike actions were evaluated in the forced swimming test. The results revealed that only the highest dose of the ethereal fraction (50 mg/kg, i.p.) caused a signifi cant decrease in total motility, locomotion and rearing. Sole dose injected (50 mg/kg) of ethanolic extract and ethereal fractions increased the exploration of the elevated plus-maze open arms in a similar way to that of diazepam (2 mg/kg, i.p.). In the forced swimming test, the ethanolic extract and their fractions (12.5, 25 or 50 mg/kg) was not as effective as paroxetine (10 or 20 mg/kg, i.p.) and imipramine (25 or 50 mg/kg, i.p.) in reducing immobility. These results suggest that some of the components of the ethanolic extract and of the ethereal fraction from B. platypetala, such as p-cymene, phytol, D-lactic acid, hexadecanoic acid, among others, may have anxiolytic-like properties, which deserve further investigation. Furthermore, the results obtained indicate that ethanolic extract from B. platypetala and their fractions do not present antidepressive properties. However, these properties cannot be related to the chemical constituents identifi ed in this specie.

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“…A total of 21 signals were observed in the 13 C-NMR spectrum of 1, which were classified by DEPT as seven CH, four Me, two CH 2 groups, and eight quaternary Catoms. The 1 H, 1 H-COSY spectrum showed the connectivity from HÀC(3) to HÀC (6), and also demonstrated couplings between CH 2 (7) and CH 2 (8), and between HÀC(3') and HÀC(4').…”

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confidence: 99%

“…The HMBC spectral data were very informative concerning the assembly of the gross structure of 1. The following 1 H, 13 C long range correlations were observed: HÀC(3) to C(1); both HÀC(4) and HÀC (6) to C(2); HÀC(5) to C(1); CH 2 (7) to C(1), C(2), and C(3); CH 2 (8) to C(5') and C(6'); the 2'-Me H-atoms to C(2') and C(3'); HÀC(3') to C(4'a); HÀC(4') to C(2'), C(5'), and C(8'a); HÀC(6') to C (8) and C(7'); the 7'-OMe H-atoms to C(7'); and the 8'-Me H-atoms to C(7'), C(8'), and C(8'a). On the basis of these spectral data, bauhinol A (1) was identified as 2-[2-(7-methoxy-2,2,8-trimethyl-2H-1-benzopyran-5-yl)ethyl]phenol.…”

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Novel Biologically Active Bibenzyls from Bauhinia saccocalyx Pierre

Apisantiyakom

Kittakoop

Manyum

et al. 2004

Chemistry & Biodiversity

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Four new bibenzyls, bauhinols A-D (1-4), together with the two known bibenzyls 5 and 6, were isolated from the roots of Bauhinia saccocalyx, and their structures were elucidated by analyses of spectroscopic data. Bauhinol A (1) exhibits significant cytotoxicity towards NCI-H187 (small-cell lung cancer), BC (breast cancer), and KB (oral-cavity cancer) cell lines, with IC50 values of 2.7-4.5 microg/ml. Bauhinol B (2) is cytotoxic against NCI-H187 (IC50 = 1.1 microg/ml) and BC (IC50 = 9.7 microg/ml) cell lines, but inactive toward the KB cell line (at 20 microg/ml). Compound 2 also is mildly antifungal towards Candia albicans (IC50 = 28.9 microg/ml). Bibenzyl 6 is active against NCI-H187 (IC50 = 14.1 microg/ml) and BC (IC50 = 4.0 microg/ml) cells, but inactive (at 20 microg/ml) toward the KB cell line. Compounds 1, 2, and 6 show mild antimycobacterial activities, with MIC values of 25-50 microg/ml, but are inactive at 20 microg/ml against the K1 malarial parasite strain (Plasmodium falciparum). While bauhinol A (1) is inactive against cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2), compounds 2 and 6 inhibit both COX-1 and COX-2, with IC50 values comparable to those of the standard drug, aspirin (Table 3).

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A flavanone and a dihydrodibenzoxepin from Bauhinia variegata

Cited by 55 publications

References 10 publications

Characterization of the molluscicidal activity of Bauhinia variegata and Mimusops elengi plant extracts against the fasciola vector lymnaea acuminata

Characterization of the molluscicidal activity of Bauhinia variegata and Mimusops elengi plant extracts against the fasciola vector lymnaea acuminata

Chemical composition and anxiolytic-like effects of the Bauhinia platypetala

Novel Biologically Active Bibenzyls from Bauhinia saccocalyx Pierre

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