materials [11,12] and sensing performances of flexible pressure sensors, such as high sensitivity, [13,14] fast response speed, [15,16] and low detection limit. [17,18] However, for practical long-term wearable applications, the wearability of pressure sensors also needs to be considered.At present, flexible, elastic, and lightweight e-skins based on polymers, especially hydrogels, have been widely investigated, but their sweat volatility, oxygen permeability, and thermal diffusivity have often been ignored. As the largest organ of the body, the skin can respire, excrete sweat, and regulate body temperature. E-skins without air permeability will insulate oxygen and prevent moisture evaporation as well as heat dissipation, causing skin discomfort and even inflammation and itching during long-term wearing. [19][20][21] Therefore, some reported studies developed e-skins with textile structures to achieve flexibility and air permeability. Yang et al. introduced graphene into polyester fabric to fabricate a graphene textile strain sensor. [22] Fu et al. reported a high-performance textile structural strain sensor by coating reduced graphene oxide (rGO) onto a glass fabric/ silicone composite. [23] Cao et al. developed a wearable piezoresistive sensor based on cotton fiber coated by rGO and silver nanowire (Ag NW) via a simple hydrothermal method. [24] The use of commercial textiles in e-skins is beneficial to simplifying the fabrication process and realizing batch manufacturing.Since 2020, electrospinning techniques that can fabricate fabric with nanostructures flexibly, economically, and quickly have gained wide attention in the field of e-skins. [25] A nanofiber (NF) network can enhance the gas permeability and reduce the effective mass density of e-skin. Peng et al. developed all-NF triboelectric nanogenerators, which were fabricated by sandwiching Ag NW between polylactic-co-glycolic acid and polyvinyl alcohol, for real-time and self-powered physiological signal monitoring. [26] Someya et al. reported the design of an all-NF triboelectric mechanoacoustic sensor by sandwiching polyvinylidene fluoride film in two pieces of Au-coated polyurethane film for continuous long-term heart monitoring. [27] Triboelectric nanogenerators are an ideal device for the self-powered monitoring of periodic physiological signals or vibrations, such as pulses, heartbeats, respiration, and vocal cord vibrations. In Electronic skins (e-skins) are a promising design paradigm for health care systems and human-machine interactions. Piezoresistive sensors made with simple structures, high sensitivity, mass production methods, light weight, and comfort for long-term wearing and physiological signal monitoring remain a challenge and are urgently desirable. Here, a breathable and lightweight all-nanofiber piezoresistive (ANFP) sensor is presented, which is composed of three layers of electrospun nanofibers (NFs). A specific interpenetrating network of conductive polyvinylpyrrolidone NFs coated by polypyrrole (PVP@PPy) and insulating polyacrylon...