A flexible and implantable piezoelectric generator harvesting energy from the pulsation of ascending aorta: in vitro and in vivo studies

Zhang, Hao; Zhang, Xiaosheng; Cheng, Xiaoliang; Yang, Lei; Han, Mengdi; Xue, Xiang; Wang, Shuaifei; Yang, Fan; Shankaregowda, Smitha Ankanahalli; Zhang, Haixia; Xu, Zhiyun

doi:10.1016/j.nanoen.2014.12.038

Cited by 169 publications

(124 citation statements)

References 14 publications

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“…However, attaching the energy harvesting device directly on the heart may cause impairment or even damage to the heart chronically. The possibility of causing cardiac damage, such as bleeding, has been raised because of heart's vigorous contraction and vulnerability [49]. Figure 6 shows a flexible and implanted PVDF piezoelectric energy harvesting generator film wrapped on an ascending aorta for harvesting energy from the pulsation of the aorta to avoid the cardiac damage.…”

Section: Generatormentioning

confidence: 99%

“…The reported results showed 4 An image attached to the outer wall of the rabbit heart with an elastic membrane containing a multifunctional sensor capable of providing electrical stimulation (the white arrows indicate the electrodes of the sensor and the fractal structure) (Reproduced with permission from Ref. [37], © 2015 WILEY VCH Verlag GmbH & Co. KGaA, Weinheim) that the average heart rate of pigs was 120 bpm and the aorta had a strain rate of about 10% due to heartbeat [49][50][51]. The instantaneous output of the PG was 30 nW and lasted for 700 ms and was charged to 1.0 V for 40 s for a 1 μF capacitor in the charge test [49].…”

Section: Generatormentioning

confidence: 99%

“…[37], © 2015 WILEY VCH Verlag GmbH & Co. KGaA, Weinheim) that the average heart rate of pigs was 120 bpm and the aorta had a strain rate of about 10% due to heartbeat [49][50][51]. The instantaneous output of the PG was 30 nW and lasted for 700 ms and was charged to 1.0 V for 40 s for a 1 μF capacitor in the charge test [49].…”

Section: Generatormentioning

confidence: 99%

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A review: flexible, stretchable multifunctional sensors and actuators for heart arrhythmia therapy

Kang¹,

Pak

2017

Micro and Nano Syst Lett

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Cardiovascular disease is a very serious disease which results in about 30% of all global mortality. Atrial fibrillation (AF) causes rapid and irregular contractions resulting in stroke and cardiac arrest. AF is caused by abnormality of the heartbeat controlling electrical signal. Catheter ablation (CA) is often used to treat and remove the abnormal electrical source from the heart but it has limitations in sensing capability and spatial coverage. To overcome the limitations of the CA, new devices for improving the spatial capability have been reported. One of the most impressive methods is wrapping the heart surface with a flexible/stretchable film with an array of high-density multifunctional micro-sensors and actuators. With this technique, the overall heart surface may be diagnosed in real time and the AF may be treated much more effectively. The data acquisition from the array of multifunctional sensors is also very important for making the new devices useful. To operate the implanted device system, a battery is mostly used and it should be avoided to replace the battery by surgery. Therefore, various energy harvesting techniques or wireless energy transfer techniques to continuously feed the power to the system are under investigation. The development of these technologies was reviewed, and the current level of technology was reviewed and summarized.

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Section: Generatormentioning

confidence: 99%

Section: Generatormentioning

confidence: 99%

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A review: flexible, stretchable multifunctional sensors and actuators for heart arrhythmia therapy

Kang¹,

Pak

2017

Micro and Nano Syst Lett

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“…Energy sources available for sensors deployed inside a physiological environment include electrochemical [4], photovoltaic [5], thermoelectric [6], mechanical [7], magnetic (inductive) [8], electromagnetic (RF) [9] and ultrasounds [10]. The efficiency in conversion to readily in-use electrical energy dictates that, for the time being, only inductive near-field, far-field RF and ultrasounds have the potential to fulfil the power requirements of the embedded electronics in the sensor.…”

Section: Guang Z Yang Imperial College London South Kensington Campusmentioning

confidence: 99%

Active implantable sensor powered by ultrasounds with application in the monitoring of physiological parameters for soft tissues

Rosa

Yang

2016

2016 IEEE 13th International Conference on Wearable and Implantable Body Sensor Networks (BSN)

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Abstract-Ultrasound imaging is a proven diagnostic tool to assess a myriad of physiological and pathological conditions in patients. Throughout the years, ultrasounds have been used as a passive recording modality where the backscattered echo arising from the interaction of the sound waves with the acoustic properties of the biological tissues helps to identify them. Apart from a wide range of therapeutic applications, the acoustic beam has not yet been explored to actuate within the biological environment in an active way. In this paper we present an implantable electronic device to be actuated remotely by ultrasounds with capabilities for measuring several physiological parameters of tissues: pH, temperature, electrolyte concentration and biopotentials. The small factory form device (with no attached batteries) harvests energy from the incoming ultrasound waves and uses it to power the embedded electronics. It operates from voltage levels as low as 0.8 V and consuming a total current of 60 µA (or an average power consumption of 84 µW) in the active mode when deployed at a distance of 3 cm from the active source of ultrasounds in vitro, excited by a sinusoid at 400 kHz with power density of 20 mWcm −2 . The sensor can be actuated by a specifically-designed readout device (as detailed in this paper) or using the traditional medical probes for ultrasound imaging. The actual device can present an alternative to surpass the limitations of inductive and RFpowered sensors implanted in soft tissues.

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“…[31][32][33] For these reasons, US Food & Drug Administration (FDA), Centers for Disease Control & Prevention (CDC), and Restriction of Hazardous Substances Directive (RoHS) have issued negative findings regarding lead-related materials and devices. [34][35][36][37] Piezoelectric polymers (e.g., polyvinylidene fluoride (PVDF)) are alternative materials for piezoelectric-bionic applications because they are soft and flexible as previously reported bioimplantations, 38,39 but they have relatively weak chemical/mechanical resistivity, and mediocre piezoelectric coupling compared to piezoelectric ceramics. 40 Recently, numerous researchers have investigated high-performance lead-free piezoelectric ceramics with perovskite-crystalline structures such as BaTiO 3 , 41,42 (Bi,Na)TiO 3 , 43 and BiFeO 3 -based ceramics.…”

mentioning

confidence: 99%

Comprehensive biocompatibility of nontoxic and high-output flexible energy harvester using lead-free piezoceramic thin film

et al. 2017

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Flexible piezoelectric energy harvesters have been regarded as an overarching candidate for achieving self-powered electronic systems for environmental sensors and biomedical devices using the self-sufficient electrical energy. In this research, we realize a flexible high-output and lead-free piezoelectric energy harvester by using the aerosol deposition method and the laser lift-off process. We also investigated the comprehensive biocompatibility of the lead-free piezoceramic device using ex-vivo ionic elusion and in vivo bioimplantation, as well as in vitro cell proliferation and histologic inspection. The fabricated LiNbO3-doped (K,Na)NbO3 (KNN) thin film-based flexible energy harvester exhibited an outstanding piezoresponse, and average output performance of an open-circuit voltage of ∼130 V and a short-circuit current of ∼1.3 μA under normal bending and release deformation, which is the best record among previously reported flexible lead-free piezoelectric energy harvesters. Although both the KNN and Pb(Zr,Ti)O3 (PZT) devices showed short-term biocompatibility in cellular and histological studies, excessive Pb toxic ions were eluted from the PZT in human serum and tap water. Moreover, the KNN-based flexible energy harvester was implanted into a porcine chest and generated up to ∼5 V and 700 nA from the heartbeat motion, comparable to the output of previously reported lead-based flexible energy harvesters. This work can compellingly serve to advance the development of piezoelectric energy harvesting for actual and practical biocompatible self-powered biomedical applications beyond restrictions of lead-based materials in long-term physiological and clinical aspects.

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A flexible and implantable piezoelectric generator harvesting energy from the pulsation of ascending aorta: in vitro and in vivo studies

Cited by 169 publications

References 14 publications

A review: flexible, stretchable multifunctional sensors and actuators for heart arrhythmia therapy

A review: flexible, stretchable multifunctional sensors and actuators for heart arrhythmia therapy

Active implantable sensor powered by ultrasounds with application in the monitoring of physiological parameters for soft tissues

Comprehensive biocompatibility of nontoxic and high-output flexible energy harvester using lead-free piezoceramic thin film

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