“…It has been employed for determining the best product portfolio and process configuration for integrated biorefineries using process simulation, production cost assessment, pinch analysis, and supply chain optimization. [40,41] An integration of product portfolio and supply chain network design in forest biorefineries as a basis for a multi-criteria decision making (MCDM) framework is another important example of the hybrid approach, and it involves introducing economic, environmental, market, and supply chain metrics. [41,42] For example, economic metrics include the internal rate of return (IRR), return on capital employed (ROCE), return on investment (ROI), net present value (NPV), competitive access to biomass (CAB), earning before interest, tax, depreciation, and amortization (EBITDA), and resistance to market uncertainty (RTMU).…”