A Flexible Procedure for Multiple Cadaveric Organ Procurement

Starzl, Thomas E.; Hakala, Thomas R.; Shaw, Brian F.; Hardesty, Robert L.; Rosenthal, Thomas J.; Griffith, B.; Iwatsuki, Shunzaburo; Bahnson, Henry T.

doi:10.1016/s0022-5347(17)49779-5

Cited by 149 publications

(154 citation statements)

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“…All liver procurements were performed by in situ infusion with UW solution (24) as part of multiple organ procurements [20,21). All of the liver grafts in this study were preserved with UW solution at 4 'Co…”

Section: Donor Operationmentioning

confidence: 99%

Can adenine nucleotides predict primary nonfunction of the human liver homograft?

et al. 1994

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Section: Donor Operationmentioning

confidence: 99%

Can adenine nucleotides predict primary nonfunction of the human liver homograft?

et al. 1994

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“…The procedure was the same in principle as that of first stage of the "flexible" multiple organ procuremem operarion currently used worldwide. 62 There was very little ischemic damage to the allografts during their postmortem imervals of 2~ to 8 hours, as indicated by modest increases in the liver injury tests (Fig. 31).…”

Section: Human Liver Replacement: 1963mentioning

confidence: 89%

The Saga of Liver Replacement, with Particular Reference to the Reciprocal Influence of Liver and Kidney Transplantation (1955–1967)

Starzl¹

2002

Journal of the American College of Surgeons

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“…The liver graft harvesting technique initially described by Starzl et al 3 consisted of a double perfusion of the liver through the aorta and portal vein. Single aortic perfusion (SAP) was introduced in recent years, proving a safe procedure with some potential advantages for multiple organ harvesting.…”

Section: Aasldmentioning

confidence: 99%

Liver transplantation using suboptimal grafts: Impact of donor harvesting technique

et al. 2007

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In recent years, an increasing number of suboptimal grafts has been used to reduce the gap between the supply and demand of organs for liver transplantation (LT). In this randomized prospective study, we tested the impact of donor harvesting technique on the posttransplantation outcome of suboptimal donor livers. A modified double perfusion (MDP) technique (aortic and portal cooling with tourniquet clamping of splenomesenteric vein inflow) was compared with the single aortic perfusion (SAP) technique. Between February and November 2005, 35 suboptimal grafts were randomly assigned to either technique (18 MDP livers and 17 SAP livers). Donor and recipient variables were comparable in the 2 study groups. The SAP group had significantly higher blood transaminases and bilirubin levels after LT. The prevalence of graft primary dysfunction (PDF) was also significantly higher (P ϭ 0.01) in the SAP group (35%) than in the MDP group (5%). In 5 cases, all in the SAP group (P ϭ 0.02), early re-LT (Ͻ30 days) was needed. The 6-month patient and graft survival rates were significantly higher in the MDP (100% in both cases) than in the SAP group (68% and 58%, respectively). The study was stopped in November 2005, when the interim analysis revealed such markedly significant differences between the two groups. In conclusion, the present study showed a very low prevalence of PDF, death, and re-LT after transplantation with suboptimal liver when a MDP technique was used to harvest the donor graft.

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A Flexible Procedure for Multiple Cadaveric Organ Procurement

Cited by 149 publications

References 0 publications

Can adenine nucleotides predict primary nonfunction of the human liver homograft?

Can adenine nucleotides predict primary nonfunction of the human liver homograft?

The Saga of Liver Replacement, with Particular Reference to the Reciprocal Influence of Liver and Kidney Transplantation (1955–1967)

Liver transplantation using suboptimal grafts: Impact of donor harvesting technique

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