This paper describes a computational infrastructure that supports Chimera-based interfacing of different CFD solvers-a body-fitted unstructured grid solver with a blockstructured adaptive cartesian grid solver-to perform time-dependent adaptive movingbody CFD calculations of external aerodynamics. The goal of this infrastructure is to facilitate the use of different solvers in different parts of the computational domain-body fitted unstructured to capture viscous near-wall effects, and cartesian adaptive mesh refinement to capture effects away from the wall. The computational infrastructure, written using Python, orchestrates execution of the different solvers and coordinates data exchanges between them, controlling the overall time integration scheme. Details about the infrastructure used to integrate the codes, the parallel implementation, and results from demonstration calculations are presented.