A FLIM photosensitizer: Targeting “Affinal” suborganelles to accelerate cancer cell oxidative stress and apoptosis

Li, Jinsong; Wang, Junjun; Zhu, Yue; Zhu, Xiaojiao; Yu, Zhipeng; Zhang, Jie; Wang, Lianke; Yu, Jianhua; Liu, Zhenbang; Zhou, Hongping

doi:10.1016/j.jphotochem.2022.114164

Cited by 3 publications

(1 citation statement)

References 37 publications

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“…[4][5][6] Recently, many organelle-targeting PSs have been developed to improve PDT efficiency because organelles associated with many fundamental life-sustaining activities have become drug targets for disease treatment. [7][8][9] For example, lipid droplets (LDs), which serve as vital organelles for storing neutral lipids in cells, play a crucial role in many physiological processes, such as cell proliferation, migration and activation. 10,11 LDs function as a vital energy source for the proliferation of tumor cells, underscoring the importance of LD-targeted PS research in PDT.…”

Section: Introductionmentioning

confidence: 99%

A dual organelle-targeting photosensitizer based on curcumin for enhanced photodynamic therapy

Wang,

Li,

Liu

et al. 2023

J. Mater. Chem. B

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Section: Introductionmentioning

confidence: 99%

A dual organelle-targeting photosensitizer based on curcumin for enhanced photodynamic therapy

Wang,

Li,

Liu

et al. 2023

J. Mater. Chem. B

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Fluorescence imaging‐guided lipid droplets‐localized photodynamic therapy

Wang,

et al. 2024

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Photodynamic therapy (PDT) has emerged as a promising strategy for cancer treatment due to its non‐invasive nature and high specificity toward malignant tissues. In recent years, a variety of protocols have been proposed to improve the PDT efficacy, of which organelle‐targeted PDT strategy is supposed to be quite promising. Particularly, lipid droplets (LDs)‐localized PDT attracts a lot of interest due to the inherent advantages such as abundant LDs in cancer cells and their close relation with ferroptosis. This review provides a comprehensive summary of the advancements of LDs‐localized photosensitizers (PSs) according to their chemical structures and functions. Especially, these PSs are featured with fluorescence emission, thereby facilitating an imaging‐guided phototherapy. The review highlights the cytocidal actions of these PSs, such as the cell death pathway and their cytotoxicity. Finally, some unresolved issues and challenges in this domain will be discussed.

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Constructing lipid droplet-targeting photosensitizers based on coumarins with NIR emission

Guo

Liu

Sha

et al. 2023

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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A FLIM photosensitizer: Targeting “Affinal” suborganelles to accelerate cancer cell oxidative stress and apoptosis

Cited by 3 publications

References 37 publications

A dual organelle-targeting photosensitizer based on curcumin for enhanced photodynamic therapy

A dual organelle-targeting photosensitizer based on curcumin for enhanced photodynamic therapy

Fluorescence imaging‐guided lipid droplets‐localized photodynamic therapy

Constructing lipid droplet-targeting photosensitizers based on coumarins with NIR emission

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