A floating multiparticulate system for ofloxacin based on a multilayer structure: In vitro and in vivo evaluation

Zhang, Chungang; Xu, Ming; Tao, Xutang; Tang, Jingya; Liu, Zitong; Zhang, Yu; Xia, Lin; He, Haibing; Tang, Xing

doi:10.1016/j.ijpharm.2012.04.013

Cited by 37 publications

(18 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gastro-retentive systems (floating tablets, pellets or beads) were successfully developed and evaluated for several category of drugs like antihistamines (cetrizeine, famotidine, ranitidine), NSAIDS (ketorolac, celecoxib), antibiotics (metronidazole, ofloxacin, amoxicillin), antidiabetics (metformin, repaglinide) and many more [8][9][10][11][12][13][14][15][16][17] .…”

Section: Introductionmentioning

confidence: 99%

Preparation and evaluation of floating tablets of pregabalin

Kanwar

Kumar

Sarwal

et al. 2015

Drug Development and Industrial Pharmacy

View full text Add to dashboard Cite

Floating tablets of pregabalin were prepared using different concentrations of the gums (xanthan gum and guar gum), Carbopol 974P NF and HPMC K100. Optimized formulations were studied for physical tests, floating time, swelling behavior, in vitro release studies and stability studies. In vitro drug release was higher for tablet batches containing guar and xanthan gum as compared to the batches containing Carbopol 974P NF. Tablet batches were subjected to stability studies and evaluated by different parameters (drug release, drug content, FTIR and DSC studies). The optimized tablet batch was selected for in vivo pharmacodynamic studies (PTZ induced seizures). The results obtained showed that the onset of jerks and clonus were delayed and extensor phase was abolished with time in treated groups. A significant difference (p > 0.05) was observed in control and treated group behavior indicating an excellent activity of the formulation for a longer period (>12 h).

show abstract

Section: Introductionmentioning

confidence: 99%

Preparation and evaluation of floating tablets of pregabalin

Kanwar

Kumar

Sarwal

et al. 2015

Drug Development and Industrial Pharmacy

View full text Add to dashboard Cite

show abstract

“…Therefore, in this study, EC was chosen and investigated as the coating material to further control the dissolution process. By retarding water penetration, the EC coating prevented the quick swelling of the matrix pellets which modulated the release pattern to an ideal sustained release (46).…”

Section: Discussionmentioning

confidence: 99%

Preparation and In Vitro–In Vivo Evaluation of Sustained-Release Matrix Pellets of Capsaicin to Enhance the Oral Bioavailability

Huang

Omari‐Siaw

et al. 2015

AAPS PharmSciTech

View full text Add to dashboard Cite

Abstract. Capsaicin has multiple pharmacological activities including antioxidant, anticancer, and antiinflammatory activities. However, its clinical application is limited due to its poor aqueous solubility, gastric irritation, and low oral bioavailability. This research was aimed at preparing sustained-release matrix pellets of capsaicin to enhance its oral bioavailability. The pellets comprised of a core of soliddispersed capsaicin mixed with microcrystalline cellulose (MCC) and hydroxypropyl cellulose (HPMC) and subsequently coating with ethyl cellulose (EC) were obtained by using the technology of extrusion/ spheronization. The physicochemical properties of the pellets were evaluated through scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and X-ray diffractometry (XRD). Besides, the in vitro release, in vivo absorption, and in vitro-in vivo correlation were also assessed. More importantly, the relative bioavailability of the sustained-release matrix pellets was studied in fasted rabbits after oral administration using free capsaicin and solid dispersion as references. The oral bioavailability of the matrix pellets and sustained-release matrix pellets of capsaicin was improved approximately 1.98-fold and 5.34-fold, respectively, compared with the free capsaicin. A good level A IVIVC (in vitro-in vivo correlation) was established between the in vitro dissolution and the in vivo absorption of sustainedrelease matrix pellets. All the results affirmed the remarkable improvement in the oral bioavailability of capsaicin owing to the successful preparation of its sustained-release matrix pellets.

show abstract

“…Nitrogen gas was used forpurging at 30 ml/min. 2 Fourier Transform Infrared Spectroscopy (FTIR): Spectra of drug and polymers were taken and analyzed for any major interaction using IR spectrophotometer (Shimadzu, model 840, Japan). These were done qualitatively in order to assess the pattern of peaks and for comparison purposes 2 .…”

Section: Drug Polymer Compatibility Studies: Differential Scanning Camentioning

confidence: 99%

Untitled

2018

IJPSR

View full text Add to dashboard Cite

Floating Drug delivery systems are designed to prolong the gastric residence time after oral administration. Ofloxacin is an antibacterial fluoroquinolone, widely prescribed in gastric and duodenal ulcers. It exhibits pH dependent solubility, more soluble in acidic pH and slightly soluble in neutral or alkaline pH. Precipitation of the drug occurs in the intestine, which adversely affects the absorption in the lower sections of the intestine. So there is a need for systems that reside in the stomach over a relatively long period and release the active compound in a sustained manner. The aim of the present study was to develop a delivery system wherein the retention of Ofloxacin could be achieved for increasing local action in the gastric region against Helicobacter pylori, with the development of rice bran oil entrapped zinc pectinate beads containing Ofloxacin. Various formulations of floating beads of Ofloxacin were developed using polymers like Low Methoxy Pectin alone and in combination with rate controlling polymers such as Gellan Gum, Karaya Gum and Xanthan Gum. The beads were prepared by emulsion gelation method. Rice bran oil was used to impart buoyancy to the beads due to its low density. The beads were spherical in nature and beads formulated with a mixture of Low Methoxy Pectin and Gellan Gum showed the highest drug content and drug entrapment. The buoyancy studies on the beads proved that a minimum of 25% w/w of rice bran oil was required to impart satisfactory buoyancy to the beads.

show abstract

A floating multiparticulate system for ofloxacin based on a multilayer structure: In vitro and in vivo evaluation

Cited by 37 publications

References 24 publications

Preparation and evaluation of floating tablets of pregabalin

Preparation and evaluation of floating tablets of pregabalin

Preparation and In Vitro–In Vivo Evaluation of Sustained-Release Matrix Pellets of Capsaicin to Enhance the Oral Bioavailability

Untitled

Contact Info

Product

Resources

About