The RISMC project aims to develop new advanced simulation-based tools to perform Computational Risk Analysis (CRA) for the existing fleet of U.S. nuclear power plants (NPPs). These tools numerically model not only the thermal-hydraulic behavior of a reactor primary and secondary systems but also external event temporal evolution and component/system ageing. Thus, this is not only a multi-physics problem but also a multi-scale problem (both spatial, m-mm-m, and temporal, ms-s-minutes-years). As part of the RISMC CRA approach, a large amount of computationally expensive simulation runs may be required. In addition, these uncertainties and safety methods usually generate a large number of simulation runs (database storage may be on the order of gigabytes or higher). During the FY2016, we investigated, implemented and applied several methods and algorithms to analyze these large amounts of time-dependent data. The scope of this report is to present a broad overview of methods and algorithms that can be used to analyze and extract information from large data sets containing time dependent data. In this context, "extracting information" means constructing input-output correlations, finding commonalities, and identifying outliers. Some of the algorithms presented here have been developed or are under development within the RAVEN statistical framework.