A Flow Injection Biosensor System for Highly Sensitive Detection of 2,4,6-Trichlorophenol Based on Preoxidation by Ceric Sulfate

Yao, Takeshi; Kotegawa, Kazuya

doi:10.2116/analsci.19.829

Cited by 11 publications

(6 citation statements)

References 32 publications

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“…However, after electrochemical oxidation (over then þ 0.30 V), two reductive peaks around þ 0.20 and 0 V are observed at the third segment, respectively. In the previous reports, some quinone products have been reported after oxidation of phenol and phenol derivates [21,22]. Other reports have indicated a quinoneimine product produced after PAP oxidation [2,23].…”

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confidence: 94%

New Determination Scheme of p‐Aminophenol by MnO₂ Modified Electrode Coupled with Flow Injection Analysis

et al. 2010

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New determination scheme of p-aminophenol by using MnO 2 as a preoxidant is demonstrated in this work. In the flow injection system, the p-aminophenol is oxidized to quinoneimine by MnO 2 at up-stream, which can be detected at a suitable reductive potential. After optimization, the linear range of PAP is started from 1 mM to 30 mM (R 2 ¼ 0.999), the estimated detection limit (S/N ¼ 3) is 0.28 mM. Two real samples are studied and excellent recoveries are achieved by using standard addition method. The p-aminophenol (PAP) is a primary hydrolytic degradation product of acetaminophen (AC) [1], and AC is very widely used as analgesic and antipyretic drug to reduce fever, cough and cold. Moreover, p-aminophenol is very harmful for human body due to its structural similarity to aniline and phenol [2]. It is limited to a low level of 0.005% in the drug substance by the European Pharmacopoeia (Ph. Eur.) [3]. The PAP or PAP derivate compounds are common pollutants in effluents from cooking oil refineries, production of pesticides and herbicides, dyes and textiles, pharmaceuticals, pulp and paper, plastics, and detergent [4], because they are extremely toxic to aquatic life and impart a strong disagreeable taste to water [5]. Several researches have reported different PAP determination schemes including high performance chromatography (HPLC), capillary electrophoresis (CE) [6 -10], optical chemical sensors [11,12] and electrochemical sensor [13 -15]. Among the aforementioned schemes, the advantages of electrochemical scheme are low cost and less time consuming. Other applications of PAP are used as electroactive polymer film [16,17] in the determination of the ascorbic acid. But the poly-PAP film only shows the electroactive property in acid condition. In the neutral or alkaline condition, it is well known, the poly-PAP is accumulated onto electrode surface leading to the electrode inactivation and the hindrance of signal in further electroanalytical measurements. Thus, the determination of PAP in neutral or alkaline condition is very hard to avoid the formation of nonconductive film on the electrode surface. Some electrode surface cleaning schemes [18 -20] or chemical modified electrodes [13 -15] have been reported to solve this problem. However, the aforementioned electrode cleaning schemes are not convenient for further application and the pulse cleaning scheme may damage the electrode surface either.In this work, the MnO 2 was modified on a dummied upstream electrode as a preoxidant to selective oxidation of the PAP. Subsequently, the oxidized product is detected by the down-stream electrode. This simple scheme avoids the polymerization effect of the PAP with direct oxidative method. Two surface water samples collected from local pond and field were adopted as real samples. The flow injection analysis (FIA) coupled with MnO 2 modified electrode is used in PAP determination without enzyme modification, complicated sample treatment procedures and expensive electrode materials.The solid line of Figure 1A shows a ...

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confidence: 94%

New Determination Scheme of p‐Aminophenol by MnO₂ Modified Electrode Coupled with Flow Injection Analysis

et al. 2010

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“…Qiu et al [36] reported an amperometric biosensor for 4-chlorophenol based on a horseradish peroxidase/gold thin film with two linear ranges (2.5-40 µM and 62.5-117.5 µM) at an applied potential of À 0.55 V. A linear range between 1 and 30 µM was reported using MnO 2 based flow injection for the determination of p-aminophenol. [37] Yao and Kotegawa [38] used a glassy carbon disc electrode and immobilized laccase with glutaraldehyde. Flow-injection measurements provided a linear range of 2 nM to 2 µM for 2, 4, 6-thrichlorephenol.…”

Section: Optimization Of Flow Rate Studies and Phenols On The Responsementioning

confidence: 99%

Electrochemical, continuous-flow determination ofp-benzoquinone on a gold nanoparticles poly(propylene-co-imidazole) modified gold electrode

Korkut

Uzunçar

Kilic

et al. 2016

Instrumentation Science & Technology

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A novel continuous flow biosensor based on gold nanoparticles and poly(propylene-co-imidazole) was developed for the online determination of p-benzoquinone. The amperometric response was measured as a function of p-benzoquinone concentration at an applied potential of À 50 mV. The hydrogen peroxide concentration was optimized and fixed at 1 mM in samples. The mass transfer resistance of the copolymer film was minimized, and the flow cell was regenerated quickly at 1 mL/min. The resulting device provided good analytical performance based on a linear dynamic range from 5-100 µM, a short response time of 3 s, a detection limit of 3.3 µM, excellent repeatability with a relative standard deviation of 0.82%, long-term stability of 95% after four weeks, and an accuracy of 105%. The gold nanoparticles enhanced the electron transfer rate on the electrode. The apparent Michaelis-Menten constant was 4 mM, showing that the enzyme retained catalytic specificity and provided high activity for p-benzoquinone.

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“…Apart from the official methods for TCP determination [31], which are based on gas and liquid chromatography and require preconcentration steps, the development of sensors is a promising alternative for screening and monitoring this chlorophenolic compound. The vast majority of the sensors reported for TCP determination are amperometric biosensors that employed enzymes as the recognition element: horseradish peroxidase [32], chloroperoxidase [33] and laccase [34].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of a Molecularly Imprinted Microgel for Electrochemical Sensing of 2,4,6‐Trichlorophenol

et al. 2010

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This article describes the synthesis and characterization of a catalytic 2,4,6-trichlorophenol molecularly imprinted microgel that could replace a natural chloroperoxidase to develop electrochemical sensors. This polymer exhibits an apparent mean particle size of 1-4 mm and high porosity, and mimics the dehalogenative function of the natural enzyme chloroperoxidase for p-halophenols. Two strategies were explored: a carbon paste modified with the polymer and the drop-coating of screen-printed electrodes with powder suspensions of the polymer and carbon nanotubes. With this last design, TCP concentrations above 25 mM could be detected. The sensor developed this way could be used for environmental waste screening.

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A Flow Injection Biosensor System for Highly Sensitive Detection of 2,4,6-Trichlorophenol Based on Preoxidation by Ceric Sulfate

Cited by 11 publications

References 32 publications

New Determination Scheme of p‐Aminophenol by MnO₂ Modified Electrode Coupled with Flow Injection Analysis

New Determination Scheme of p‐Aminophenol by MnO₂ Modified Electrode Coupled with Flow Injection Analysis

Electrochemical, continuous-flow determination ofp-benzoquinone on a gold nanoparticles poly(propylene-co-imidazole) modified gold electrode

Preparation and Characterization of a Molecularly Imprinted Microgel for Electrochemical Sensing of 2,4,6‐Trichlorophenol

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A Flow Injection Biosensor System for Highly Sensitive Detection of 2,4,6-Trichlorophenol Based on Preoxidation by Ceric Sulfate

Cited by 11 publications

References 32 publications

New Determination Scheme of p‐Aminophenol by MnO2 Modified Electrode Coupled with Flow Injection Analysis

New Determination Scheme of p‐Aminophenol by MnO2 Modified Electrode Coupled with Flow Injection Analysis

Electrochemical, continuous-flow determination ofp-benzoquinone on a gold nanoparticles poly(propylene-co-imidazole) modified gold electrode

Preparation and Characterization of a Molecularly Imprinted Microgel for Electrochemical Sensing of 2,4,6‐Trichlorophenol

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New Determination Scheme of p‐Aminophenol by MnO₂ Modified Electrode Coupled with Flow Injection Analysis

New Determination Scheme of p‐Aminophenol by MnO₂ Modified Electrode Coupled with Flow Injection Analysis