A fluorescence “turn-on” probe for Cu (Ⅱ) based on flavonoid intermediates generated by copper-induced oxidative cyclization and its fluorescence imaging in living cells

Ji, Liguo; Fu, Yutian; Yang, Nan; Wang, Meifei; Yang, Linlin; Wang, Qingzhi; Shang, Wanbing; He, Guangjie

doi:10.1016/j.ab.2022.114855

Cited by 3 publications

(1 citation statement)

References 35 publications

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“…The sensor could detect exogenous Cu(II) in HepG2 cells. In a similar strategy employed by the Ji, Shang and He’s groups 314 was developed, in which a coumarin was appended to a 1-hydroxy-2-acetylnaphthalene that undergoes a Cu(II)-mediated cyclization to generate a fluorescent flavonoid, producing a 200-fold fluorescence response in 1:1 CH 3 CN/HEPES, and allowing for Cu(II) imaging in HeLa cells pre-treated with Cu(II) . While metal selectivity was validated for both of these sensors, Cu(I) response was not tested for either.…”

Section: Fluorescent Sensors For Coppermentioning

confidence: 99%

Small-Molecule Fluorescent Probes for Binding- and Activity-Based Sensing of Redox-Active Biological Metals

Grover,

Koblova,

Pezacki

et al. 2024

Chem. Rev.

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Although transition metals constitute less than 0.1% of the total mass within a human body, they have a substantial impact on fundamental biological processes across all kingdoms of life. Indeed, these nutrients play crucial roles in the physiological functions of enzymes, with the redox properties of many of these metals being essential to their activity. At the same time, imbalances in transition metal pools can be detrimental to health. Modern analytical techniques are helping to illuminate the workings of metal homeostasis at a molecular and atomic level, their spatial localization in real time, and the implications of metal dysregulation in disease pathogenesis. Fluorescence microscopy has proven to be one of the most promising non-invasive methods for studying metal pools in biological samples. The accuracy and sensitivity of bioimaging experiments are predominantly determined by the fluorescent metal-responsive sensor, highlighting the importance of rational probe design for such measurements. This review covers activity-and binding-based fluorescent metal sensors that have been applied to cellular studies. We focus on the essential redox-active metals: iron, copper, manganese, cobalt, chromium, and nickel. We aim to encourage further targeted efforts in developing innovative approaches to understanding the biological chemistry of redox-active metals. CONTENTS5908 8.2. Activity-Based Fluorescent Sensors for Ni(II) 5911 9. Outlook 5911 Author Information 5912 Corresponding Authors 5912

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Section: Fluorescent Sensors For Coppermentioning

confidence: 99%

Small-Molecule Fluorescent Probes for Binding- and Activity-Based Sensing of Redox-Active Biological Metals

Grover,

Koblova,

Pezacki

et al. 2024

Chem. Rev.

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Synthesis and Properties of a Triphenylamine‐Based Fluorescent Probe for the Continuous Detection of Cu²⁺ and EDTA

Hu,

Yao,

Deng

et al. 2024

ChemistrySelect

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A fluorescent probe NS was successfully developed using triphenylamine aldehyde and 1‐hydroxy‐2‐naphthaldehyde. NS demonstrated selective recognition of Cu2+ in a DMSO/H2O solution, forming a stable 1 : 1 complex that led to fluorescence quenching. The addition of EDTA resulted in fluorescence recovery. The fluorescent intensity of NS showed a linear correlation with Cu2+ concentration within the range of 2~14 μmol ⋅ L−1, with a detection limit of 39 nmol ⋅ L−1 and a binding constant of 1.56×103 L mol−1. Additionally, the detection limit of the NS‐Cu2+ complex for EDTA was calculated to be 187 nmol ⋅ L−1. NS also displayed promising applications in the environmental and alcoholic drinks for detecting Cu2+ in water, wine, and Chinese Baijiu samples.

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A novel lysosomal targeted near-infrared probe for ratio detection of carbon monoxide in cells and in vivo

Ji,

Fu,

Liu

et al. 2024

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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A fluorescence “turn-on” probe for Cu (Ⅱ) based on flavonoid intermediates generated by copper-induced oxidative cyclization and its fluorescence imaging in living cells

Cited by 3 publications

References 35 publications

Small-Molecule Fluorescent Probes for Binding- and Activity-Based Sensing of Redox-Active Biological Metals

Small-Molecule Fluorescent Probes for Binding- and Activity-Based Sensing of Redox-Active Biological Metals

Synthesis and Properties of a Triphenylamine‐Based Fluorescent Probe for the Continuous Detection of Cu²⁺ and EDTA

A novel lysosomal targeted near-infrared probe for ratio detection of carbon monoxide in cells and in vivo

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A fluorescence “turn-on” probe for Cu (Ⅱ) based on flavonoid intermediates generated by copper-induced oxidative cyclization and its fluorescence imaging in living cells

Cited by 3 publications

References 35 publications

Small-Molecule Fluorescent Probes for Binding- and Activity-Based Sensing of Redox-Active Biological Metals

Small-Molecule Fluorescent Probes for Binding- and Activity-Based Sensing of Redox-Active Biological Metals

Synthesis and Properties of a Triphenylamine‐Based Fluorescent Probe for the Continuous Detection of Cu2+ and EDTA

A novel lysosomal targeted near-infrared probe for ratio detection of carbon monoxide in cells and in vivo

Contact Info

Product

Resources

About

Synthesis and Properties of a Triphenylamine‐Based Fluorescent Probe for the Continuous Detection of Cu²⁺ and EDTA