A fluorescent assay for cryptic transcription inSaccharomyces cerevisiaereveals novel insights into factors that stabilize chromatin structure on newly replicated chromatin
Abstract:The disruption of chromatin structure can result in transcription initiating from cryptic promoters. A well-characterized, chromatin-destabilizing stress is the passage of RNA polymerase, and numerous factors function to stabilize chromatin on transcribed genes, suppressing cryptic transcription from sites within gene bodies. DNA replication is also inherently disruptive to chromatin, and multiple replication-coupled histone chaperones suppress cryptic transcription. However, these factors also have documented… Show more
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