A fluorescent probe for the dual detection of mercury ions and thiols based on a simple coumarin derivative

Pei, Tao; Chen, Dongliang; Xu, Zhenxiang; Song, Yanxi; Li, Hongqi; Xian, Chunying

doi:10.1111/cote.12447

Cited by 22 publications

(12 citation statements)

References 51 publications

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“…The reduction in the absorption intensity from 0.35 a.u to 0.15 a.u for both the metal ions is compatible with the reported literature [46] . Thus, a minimum limit of detection as calculated using equation approved by IUPAC (LOD=3 σ/k) was found to be 27×10 −9 M and 0.16×10 −6 M for Hg 2+ and Cu 2+ ions respectively which is comparable to the values reported in the literature [13–35,39] …”

Section: Resultssupporting

confidence: 82%

“…Diphenyl ether (Compd-1) required for the purpose was synthesized by a known procedure via nucleophilic aromatic substitution on 2-fluoro-4-nitro benzaldehyde by ortho-methoxyphenol. [46] Both the compounds were characterized for their identity and purity by 1 H, 13 C NMRs and HPLC respectively (Supplementary Information Figure S1 to S6).…”

Section: Design Of the Receptormentioning

confidence: 99%

“…[11][12] Several sensors for the mercury, based on organic molecules and polymers have been reported in the literature. This includes use of coumarin, [13,14] hydroxyl chromones, [15] triazole, [16,17] benzimidazole, [18,19] benzothiadiazole, [20,21] thiophene, [22,23] porphyrin, [24,25] naphthalenediimide, [26,27] naphthyridine, [28,29] naphthalimides, [29,30] BODIPY, [31,32] 1-(2-aminoethyl)thioureas, [33] and dansylamides [34] groups to create optical probes that can work in organic or aqueous medium with a detection range of 10 À 5 to 10 À 10 M. Cleavage of the spirolactam ring in the rhodamine derivatives forms the basis of many Hg 2 + ion sensors. [35] The use of phenyl ethers for the detection of various cations and anions has recently been demonstrated.…”

Section: Introductionmentioning

confidence: 99%

“…[18] Another Hg 2 + and thiol selective coumarin derivative displayed increased emission intensity with increasing concentration of water in ethanol (9 : 1). [13] Present work also describes the use of a ninety-nine percent aqueous medium to detect Hg 2 + and Cu 2 + ions.…”

Section: Introductionmentioning

confidence: 99%

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Determination of Mercury Ions in Aqueous Medium and Urine Sample Using Thiocarbohydrazide Based Sensor

Kumar

Chhibber

2020

ChemistrySelect

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The identification and quantification of toxic Hg 2 + ions in biological fluids is significant due to its harmful effects. The ion is an exceptional contaminant due to its manifestation in the environment through anthropogenic emissions besides other industrial processes. The bioaccumulation of Hg 2 + ions through water bodies, soil and food causes damage to the central nervous system and endocrine glands. This work describes the synthesis of Compd-2 (Compound 2), a thiocarbohydrazidebased UV-active sensor, that can detect Hg 2 + and Cu 2 + ions in the aqueous medium (HEPES buffer (3 mM) /acetonitrile = 99 : 1, v/v). Compd-2 responds linearly to the varying concentrations of Hg 2 + with a minimum detection limit of 27 nM and a 1 : 1 stoichiometry. 1 H NMR titration with increasing Hg 2 + ion concentrations confirmed its interaction by shifting of the peak. In-silico modelling using Gaussian 16.0 and IR spectroscopy verified a single binding site for the Hg 2 + ions. Aqueous solubility of Compd-2 was used as an advantage to develop a methodology for the detection and quantification of Hg 2 + ions in the human urine sample. The work also demonstrates the nM quantification of Hg 2 + ions in the urine sample by the standard addition method.

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Section: Resultssupporting

confidence: 82%

Section: Design Of the Receptormentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Determination of Mercury Ions in Aqueous Medium and Urine Sample Using Thiocarbohydrazide Based Sensor

Kumar

Chhibber

2020

ChemistrySelect

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“…Stimuli‐responsive and smart materials have always been at the forefront of various material science applications 1‐17 . Among these stimuli‐responsive materials, fluorescent materials have been used as smart functional materials in multidisciplinary areas, including chemosensor and biosensor design, 18‐22 biomedical applications, 23,24 imaging processes, 25,26 light‐emitting diode device fabrication 27,28 and the tagging of biomolecules 29‐31 and photoswitches 32,33 .…”

Section: Introductionmentioning

confidence: 99%

Colorimetric sensing of acidic vapour through protonation of a Meisenheimer complex

Das

Mohar

2020

Coloration Technology

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In the current work, we investigate the mechanism of protonation of a Meisenheimer complex derived from picric acid and N,N′‐dicyclohexylcarbodiimide to provide the correct structure of the protonated Meisenheimer complex with the proper mechanism. A substituted picramide derivative has also been synthesised and characterised using various spectroscopic techniques to rule out the previously suggested protonated Meisenheimer complexes and support our proposed protonated structure. Various other investigations, including the interactions of the Meisenheimer complex with bulky electrophile Lawesson's reagent and bulky Lewis acid Eu(fod)3, were also carried out to support the mechanism of protonation. Various bulky bases as well as bases of different strengths were treated with the protonated Meisenheimer complex to support our proposed structure. Based on the protonation of the Meisenheimer complex, a general colorimetric volatile acid sensor has been designed, where a distinct colour change from orange to colourless was found to take place after protonation. The sensor can detect volatile acids both in the solid and in the solution state. The sensor was also applied to detect hydrogen chloride vapour in an automated manner using a smartphone, where information regarding the leakage position can be obtained through wireless communication. The detection limit of hydrogen chloride vapour was found to be 43.5 ppm.

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Coumarin‐based Chemosensors for Metal Ions Detection

et al. 2022

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Coumarins, due to their intense and persistent emission of fluorescence, structural flexibility, and excellent biocompatibility, have become a popular choice in developing new fluorescent chemosensors. Coumarins have long been used for sensing anions, cations, chemically reactive nitrogen, oxygen, sulfur-containing species, and small molecules. They have also been shown to have applicability in imaging, biology, and medical research. Due to the widespread use and excellent biological activity, hundreds of such coumarin motifs have either been isolated from nature or synthesized in a laboratory. This review covers all the developments pertaining to the synthesis and use of coumarin for sensing a variety of metal ions (alkali, alkaline earth, transition, heavy, and noble metal ions). This comprehensive review includes an overview of the coumarin-based chemosensor's pH limit, detection limit, and binding mode. A brief explanation of the stoichiometric ratio between metal and chemosensor moiety and the applicability of each chemosensor is also given.

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A fluorescent probe for the dual detection of mercury ions and thiols based on a simple coumarin derivative

Cited by 22 publications

References 51 publications

Determination of Mercury Ions in Aqueous Medium and Urine Sample Using Thiocarbohydrazide Based Sensor

Determination of Mercury Ions in Aqueous Medium and Urine Sample Using Thiocarbohydrazide Based Sensor

Colorimetric sensing of acidic vapour through protonation of a Meisenheimer complex

Coumarin‐based Chemosensors for Metal Ions Detection

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