A fluorimetric study of pindolol and its complexes with cyclodextrins

Gazpio, Carmen; Sánchez, Miguel; Zornoza, Arantza; Martı́n, Carmen; Martínez-Ohárriz, Cristina; Vélaz, Itziar

doi:10.1016/s0039-9140(03)00077-8

Cited by 21 publications

(6 citation statements)

References 7 publications

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“…1,8 When administered in high doses it can mistakenly cause bronchodilation and tachycardia. 9 Analytical techniques reported within the literature for the determination of pindolol include spectrofluorimetry, 10 liquid chromatography-tandem mass spectrometry 11 and high-performance liquid chromatography. [12][13][14] Notably however, only one report for the electrochemical determination of pindolol exists within the literature; 15 which is a potentially rapid, facile and low cost protocol for the monitoring of such a key analyte.…”

Section: Introductionmentioning

confidence: 99%

Electroanalytical detection of pindolol: comparison of unmodified and reduced graphene oxide modified screen-printed graphite electrodes

Cumba

Smith

Brownson

et al. 2015

Analyst

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Recent work has reported the first electroanalytical detection of pindolol using reduced graphene oxide (RGO) modified glassy carbon electrodes [S. Smarzewska and W. Ciesielski, Anal. Methods, 2014, 6, 5038] where it was reported that the use of RGO provided significant improvements in the electroanalytical signal in comparison to a bare (unmodified) glassy carbon electrode. We demonstrate, for the first time, that the electroanalytical quantification of pindolol is actually possible using bare (unmodified) screen-printed graphite electrodes (SPEs). This paper addresses the electroanalytical determination of pindolol utilising RGO modified SPEs. Surprisingly, it is found that bare (unmodified) SPEs provide superior electrochemical signatures over that of RGO modified SPEs. Consequently the electroanalytical sensing of pindolol is explored at bare unmodified SPEs where a linear range between 0.1 μM-10.0 μM is found to be possible whilst offering a limit of detection (3σ) corresponding to 0.097 μM. This provides a convenient yet analytically sensitive method for sensing pindolol. The optimised electroanalytical protocol using the unmodified SPEs, which requires no pre-treatment (electrode polishing) or electrode modification step (such as with the use of RGO), was then further applied to the determination of pindolol in urine samples. This work demonstrates that the use of RGO modified SPEs have no significant benefits when compared to the bare (unmodified) alternative and that the RGO free electrode surface can provide electro-analytically useful performances.

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Section: Introductionmentioning

confidence: 99%

Electroanalytical detection of pindolol: comparison of unmodified and reduced graphene oxide modified screen-printed graphite electrodes

Cumba

Smith

Brownson

et al. 2015

Analyst

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“…Many physicochemical methods were applied to investigate the complexation reaction between CDs and guest molecule, including phase solubility measurements , UV–Vis , fluorescence , circular dichroism , and NMR spectroscopy. Furthermore, many separation‐based methods such as HPLC and CE were also used to study the host–guest interaction.…”

Section: Introductionmentioning

confidence: 99%

Structure selective complexation of cyclodextrins with five polyphenols investigated by capillary electrokinetic chromatography

Cheung

Shangguan

Zheng

2012

J of Separation Science

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The complexation of five polyphenols, namely trans-resveratrol, astilbin, taxifolin, ferulic acid, and syringic acid (guest molecules) with α-, β-, and γ-cyclodextrin (host molecules), was investigated by capillary electrokinetic chromatography. The binding constants were calculated based on the effective electrophoretic mobility change of guests with the addition of cyclodextrins into the background electrolyte. Because of cavity size, cyclodextrins showed structure-selective complexation property to different guest. The stability of the trans-resveratrol complexes was in the order of β- > α- > γ-cyclodextrin. The cavity size of α-cyclodextrin was too small for astilbin and taxifolin molecules, and thus they could not form complexes. The molecular size of syringic acid was too big for all cyclodextrins cavity, and no cyclodextrin could form complexes with it. Temperature studies showed that the binding constants decreased with the rise of temperature. Enthalpy and entropy values were calculated and the negative values of these parameters indicated that the complexation process was enthalpy-controlled. Van der Waals force and release of high-enthalpy water molecules from the cyclodextrins cavity played important roles in the process.

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“…; the positive slope may indicate an increase in the dipolar moment upon excitation, and there is a marked deviation from linearity in protic solvents, which is associated with specific solvent effects. The fluorescent red shift in protic solvents could be due to a charge‐transfer type of interaction between excited CENS and the solvent molecule .…”

Section: Resultsmentioning

confidence: 99%

Solvent effects of N‐nitroso, N‐(2‐chloroethyl), N′,N′‐dibenzylsulfamid and its copper(II) and cobalt(II) complexes: fluorescence studies

et al. 2012

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The structure of N-nitroso, N-(2-chloroethyl), N',N'-dibenzylsulfamid (CENS) was established by X-ray crystallography. The atomic coordinates, factors of isotropic thermal agitation, bond lengths and valence angles were determined. The solvent effects on the electronic absorption and fluorescence spectra of CENS were investigated at room temperature. The effects of solvent polarity and of hydrogen bonding were interpreted by means of linear solvation energy relationships (LSERs). Multiple linear regression analysis indicated that the hydrogen donation properties of the solvent play an important role in determining the position of the absorption maximum, while the classical polarity of the medium is the only dominating parameter in determining the emission maximum and the Stokes' shift. Complexation of the investigated compound by two different transition metal ions was studied. Fluorescence measurements show that fluorescence quenching by cobalt(II) is more important than that by copper(II). This phenomenon can be attributed to good stereo-structural matching between the electronic configuration of the Co(2+) ion and the active site distribution of CENS in aqueous solution.

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A fluorimetric study of pindolol and its complexes with cyclodextrins

Cited by 21 publications

References 7 publications

Electroanalytical detection of pindolol: comparison of unmodified and reduced graphene oxide modified screen-printed graphite electrodes

Electroanalytical detection of pindolol: comparison of unmodified and reduced graphene oxide modified screen-printed graphite electrodes

Structure selective complexation of cyclodextrins with five polyphenols investigated by capillary electrokinetic chromatography

Solvent effects of N‐nitroso, N‐(2‐chloroethyl), N′,N′‐dibenzylsulfamid and its copper(II) and cobalt(II) complexes: fluorescence studies

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