Neurosurgical procedures
often cause
damage to the brain tissue at the periphery from surgical manipulations.
Especially during retraction, a large amount of pressure could be
applied on the brain surface, which can damage it, leading to brain
herniation, which can be fatal for patients. To resolve this issue,
we have developed a pressure sensor that can be used to monitor the
applied pressure during surgery for intraoperative care. This device
was tested on a rodent model to create a superficial surgically induced
damage profile for three different applied pressures (30, 50, and
70 mmHg) and compared to a standard intracranial pressure monitoring
system. Magnetic resonance imaging has been performed after surgical
procedures to detect the herniation caused by applied pressure. To
evaluate the damage to brain cells and tissue rupture, histological
analysis was performed using hematoxylin and eosin staining. A scoring
system was developed to understand the severity of the surgically
induced brain injury, which will help neurosurgeons to limit the pressure
to an optimum point without causing damage.