This study presents a systematic review of studies related to murder and criminal investigation, policing, and implications for forensic science application in Nigeria. A literature search was done in the English language, using primary and secondary keywords; such as murder investigation, forensic science, policing, criminal investigation, standard operating procedures guiding murder investigation, and application of forensic science in Nigeria. Four academic databases selected for the study were: SAGE Online, Wiley Online Library, Science Direct, and Google Scholar. Following the inclusion and exclusion criteria earmarked for the study, 16 selected online published materials published between 2012 and 2022 met the predetermined criteria. These articles are either surveys, reviews, case studies, expert opinion materials, or theoretical articles. Central to the findings of these articles is that the application of forensic science in murder investigations in Nigeria is still suboptimal, accounting for lots of cold and unresolved murder cases across the country. In addition, there are other issues such as inadequate legislation governing forensic science application in Nigeria, lack of forensic skills and poor capacity development of Nigerian police, and non-adherence to forensic validated procedures during murder investigations. Gaps identified from these studies suggest a need for research focusing on the importance of suspect forensic profiling, a criminal investigative tool that can aid in narrowing down the suspect pool which has become a perennial problem in Nigeria's justice system as evidenced by the rising number of murder suspects across the country’s penitentiaries. This would make murder investigation more effective and efficient for criminal justice experts.<p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/soc/0788/a.php" alt="Hit counter" /></p>