A Formula for the Estimation of 24-Hour Urinary Creatinine Excretion: A Derivation and Validation Study

Kimura, Yoshiki; Azuma, Yuki; Notsu, Shoki; Bessho, Saki; Kobori, Aimi; Kubota, Takuya; Shimomura, Atsushi; Iwatani, Hirotsugu

doi:10.1053/j.jrn.2021.05.002

Journal of Renal Nutrition

2022

DOI: 10.1053/j.jrn.2021.05.002

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A Formula for the Estimation of 24-Hour Urinary Creatinine Excretion: A Derivation and Validation Study

Yoshiki Kimura

Yuki Azuma

Shoki Notsu

et al.

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Cited by 3 publications

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“…Iocca et al 31 contrived a way to include ice cream in the renal diet to aid in increasing energy intake while holding phosphorus low. Kimura et al 32 provide a prediction equation for estimating 24-hour urinary creatinine that includes a creatinine-based estimate of kidney function, age, sex, height, and weight and operates across a wide range of kidney function. The patient education piece provided in this issue of the Journal is a guidance developed by Ives 33 regarding gastroparesis with tips for managing their gastroparesis in view of also having kidney disease.…”

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confidence: 99%

Global Kidney Nutrition Care and Health Literacy: Overcoming the Disparities in Renal Nutrition Service Capacity and Education

Moore

Wang

Kalantar‐Zadeh

2022

Journal of Renal Nutrition

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mentioning

confidence: 99%

Global Kidney Nutrition Care and Health Literacy: Overcoming the Disparities in Renal Nutrition Service Capacity and Education

Moore

Wang

Kalantar‐Zadeh

2022

Journal of Renal Nutrition

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Medication dosing in adult patients with reduced lean body mass and kidney injury: A focus on cystatin C

Erstad

Nix

2023

American Journal of Health-System Pharmacy

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Disclaimer In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. Purpose Creatinine-based estimates of glomerular filtration rate (GFR) have been the standard for classifying kidney function and guiding drug dosing for over 5 decades. There have been many efforts to compare and improve different methods to estimate GFR. The National Kidney Foundation recently updated the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations without race for creatinine (CKD-EPIcr_R) and creatinine and cystatin C (CKD-EPIcr-cys_R), and the 2012 CKD-EPI equation based on cystatin C (CKD-EPIcys) remains. The focus of this review is to highlight the importance of muscle atrophy as a cause for overestimation of GFR when using creatinine-based methods. Summary Patients with liver disease, protein malnutrition, inactivity, denervation, or extensive weight loss may exhibit markedly lower creatinine excretion and serum creatinine concentration, leading to overestimation of GFR or creatinine clearance when using the Cockcroft-Gault equation or CKD-EPIcr (deindexed). In some cases, estimated GFR appears to exceed the physiological normal range (eg, >150 mL/min/1.73 m 2). Use of cystatin C is recommended when low muscle mass is suspected. One would expect discordance between the estimates such that CKD-EPIcys < CKD-EPIcr-cys < CKD-EPIcr ≈ Cockcroft-Gault creatinine clearance. Clinical evaluation can then occur to determine which estimate is likely accurate and should be used for drug dosing. Conclusion In the setting of significant muscle atrophy and stable serum creatinine levels, use of cystatin C is recommended, and the resulting estimate can be used to calibrate interpretation of future serum creatinine measurements.

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Efficacy of comprehensive group-based education in lowering body weight, uric acid levels, and diuretic use in patients with chronic kidney disease: a retrospective study

Hotta,

Iwatani

2023

BMC Nephrol

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Background Patient education for the management of chronic kidney disease (CKD) is attracting attention. Therefore, this study aimed to analyze changes in body weight, uric acid, and estimated-glomerular filtration rate (eGFR) in patients with CKD after a group-based education during admission. Methods Overall, 157 patients with CKD, who were discharged from the nephrology department of our hospital between January 2015 and October 2019, received group-based education or individual-based education by nurses at admission. Deltas of body weight, uric acid, and eGFR, 6 months from baseline, were compared between group- and individual-based education using the Wilcoxon rank sum test. Results In total, 60 patients receiving group-based education (G group, n =35) or individual-based education (I group, n =25) during admission were included in this retrospective study. The patient characteristics at baseline were as follows: age mean, 72 ± SD 9; 16 females and 44 males; body weight, 62 ± 17 kg; eGFR median, 21 (IQR: 14, 29) mL/min/1.73 m2; UA, 7 (6.1, 7.5) mg/dL; and estimated intake of salt 6.9 (6.2, 8.4) g/day. Delta eGFR (mL/min/1.73 m2) was -1 (-3, 3) for G group and -1 (-2.5, 2) for I group (p = 0.8039). Delta body weight (kg) was -0.4 (-1.6, 0) for G group and 0 (-0.45, 0.95) for I group (p = 0.0597). Delta uric acid (mg/dL) was -1.1 (-1.6, 0.1) for G group and -0.2 (-1.1, 0.5) for I group (p = 0.0567). In patients with higher sodium intake (≥ 117.4 mEq/day), delta body weight was significantly lower in the group-based education group than in the individual-based education group (p = 0.0398). Conclusions A comprehensive group-based education in patients with CKD may effectively suppress body weight and uric acid in 6 months along with less frequent diuretic use.

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A Formula for the Estimation of 24-Hour Urinary Creatinine Excretion: A Derivation and Validation Study

Cited by 3 publications

References 19 publications

Global Kidney Nutrition Care and Health Literacy: Overcoming the Disparities in Renal Nutrition Service Capacity and Education

Global Kidney Nutrition Care and Health Literacy: Overcoming the Disparities in Renal Nutrition Service Capacity and Education

Medication dosing in adult patients with reduced lean body mass and kidney injury: A focus on cystatin C

Efficacy of comprehensive group-based education in lowering body weight, uric acid levels, and diuretic use in patients with chronic kidney disease: a retrospective study

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