2021
DOI: 10.3906/kim-2105-59
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A four-component modified Biginelli reaction: A novel approach for C-2 functionalized dihydropyrimidines

Abstract: A novel four component modified Biginelli reaction for the synthesis of C-2 functionalized dihydropyrimidines has been established. The approach uses assembly of less explored acetyl acetone with aromatic aldehyde, thiourea and dimethyl sulphate to construct a novel 5-acetyl 2-methylthio dihydropyrimidine system which works as an efficient well-designed intermediate for generating C-2 modified Biginelli libraries with nitrogen nucleophiles. Phenyl hydrazine, semicarbazide and aryl semicarbazides are successful… Show more

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