Acknowledging the growing impact of nanotechnologies across various fields, this engaging research paper focuses on harnessing the potential of nano-sized materials as enhancers for concretes. The paper emphasizes the strategic integration of these entities to comprehensively improve the strength and performance of concrete matrixes. To achieve this, an analytical study is conducted to investigate the static behavior of concrete beams infused with different types of clay nano-platelets (NC’s), employing quasi-3D beam theory. The study leverages the effective Eshelby’s homogenization model to determine the equivalent elastic characteristics of the nanocomposite. The intricate interactions of the soil medium are captured through the use of a Winkler–Pasternak elastic foundation. By employing virtual work principles, the study derives equations of motion and proposes analytical solutions based on Navier’s theory to unravel the equilibrium equations of simply supported concrete beams. The results shed light on influential factors, such as the clay nano-platelet type, volume percentage, geometric parameters, and soil medium, providing insights into the static behavior of the beams. Moreover, this research presents previously unreported referential results, highlighting the potential of clay nano-platelets as reinforcements for enhancing structural mechanical resistance.