A four year prospective study of age-related 
cognitive change in adults with Down's syndrome

Oliver, Chris; Crayton, Lissa; Holland, Anthony; Hall, S. Kate; Bradbury, June

doi:10.1017/s0033291798007417

Cited by 146 publications

(178 citation statements)

References 34 publications

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“…Since one-third of people with severe learning disabilities have Down's syndrome, and because of increasing longevity, they contribute significantly to the numbers of people who have dementia (Cooper, 1997). It should be noted, however, that the prevalence of cognitive impairments consistent with the presence of Alzheimer's disease is not as high as would be expected from neuropathological studies (Oliver et al, 1998). Cooper (1997) has shown that dementia is also more frequent among elderly people with learning disabilities who do not have Down's syndrome than among the wider elderly population.…”

Section: Mental Healthmentioning

confidence: 97%

Working with elderly carers of people with learning disabilities and planning for the future

Hubert¹,

Hollins²

2000

Adv. psychiatr. treat

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The majority of people with learning disabilities in the UK live at home with their families, usually with their parents (Mental Health Foundation, 1996) or – more commonly in later life – with one parent, usually their mother. Nowadays, people with learning disabilities live much longer than they did in the past, with the result that there is also an expanding population of elderly parents who are continuing to care for a son or daughter well into old age.

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Section: Mental Healthmentioning

confidence: 97%

Working with elderly carers of people with learning disabilities and planning for the future

Hubert¹,

Hollins²

2000

Adv. psychiatr. treat

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“…There appears to be no relationship between level of learning disability and risk of dementia or age at onset of dementia . The rate of deterioration appears to increase with age (Oliver et al, 1998). The level of pre-existing cognitive function is also closely associated with the rate of decline (Temple et al, 2001).…”

Section: Epidemiology and Aetiologymentioning

confidence: 99%

“…Early-onset symptoms may vary from person to person, but there is evidence that the acquisition of deficits tends to mimic those seen in Alzheimer's disease generally (Oliver et al, 1998). Deterioration in memory, learning and orientation tend to be the first signs, and these symptoms are often accompanied by increased dependence (Cosgrave et al, 2000).…”

Section: Presentation Of Dementia In Down's Syndromementioning

confidence: 99%

Down's syndrome and dementia

Stanton¹,

Coetzee²

2004

Adv. psychiatr. treat

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). Her research interests are in liaison in old age psychiatry, the interface between old age psychiatry and learning disability services, and neuropsychiatry. Rikus Coetzee is also a specialist registrar in general adult psychiatry and old age psychiatry at Duncan Macmillan House, Nottingham. His research interests are in the treatment and epidemiology of trauma-related neurosis in the elderly and the use of cognitive-behavioural therapy with elderly people. Down's syndrome and dementiaLisa R. Stanton & Rikus H. Coetzee Abstract Down's syndrome is the most common genetic disorder seen in clinical practice: about 94% occurs because of non-disjunction of chromosome 21 and 3-5% because of translocation. Individuals increasingly survive to middle and old age, probably because of advances in medical treatment and improved living conditions. People with Down's syndrome have an increased risk of developing Alzheimer's disease in middle age. Within ICD-10 and DSM-IV classifications there is no consensus on the diagnosis of dementia in people with learning disability. New treatments have been licensed for use in mild to moderate Alzheimer's disease (e.g. acetylcholinesterase inhibitors and memantine). The comorbid picture of Down's syndrome and Alzheimer's disease presents a unique challenge to the clinician in both diagnosis and management.

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“…This risk increases with age and is greater for relatives of individuals with early-onset rather than late-onset (63). Late-onset AD appears to result from multiple mutations that create a predisposition for the disease.…”

Section: Non-modifiable Risk Factorsmentioning

confidence: 99%

Will a Healthy Lifestyle Help Prevent Alzheimer's Disease?

Pope

Shue

Beck

2003

Annu. Rev. Public Health

114

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Alzheimer's disease (AD) appears to resemble other chronic diseases, whereby a myriad of interconnected factors, including those associated with lifestyle, are involved in disease development. In this paper, we examine accepted and proposed risk factors for AD and explore health behaviors, including diet, exercise, prevention of injury, and cognitive stimulation, that may help prevent AD. Adherence to a healthy lifestyle may directly protect against AD or may prevent diseases associated with AD, such as vascular disease and diabetes. A healthy lifestyle to prevent AD may be important throughout life rather than after disease manifestation and may be particularly relevant if other factors, such as genetic predisposition, also increase risk of AD. If changes in lifestyle can help prevent AD by reducing modifiable risk factors, this knowledge can aid individuals who wish to take action to protect themselves and their families from the disease.

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A four year prospective study of age-related cognitive change in adults with Down's syndrome

Cited by 146 publications

References 34 publications

Working with elderly carers of people with learning disabilities and planning for the future

Working with elderly carers of people with learning disabilities and planning for the future

Down's syndrome and dementia

Will a Healthy Lifestyle Help Prevent Alzheimer's Disease?

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