2021
DOI: 10.1016/j.csbj.2021.06.006
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A fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of Mycobacterium tuberculosis

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Cited by 21 publications
(19 citation statements)
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“…Ornithine acetyltransferase (ArgJ) is one of eight essential enzymes within the l -arginine biosynthesis pathway, which is critical for Mtb survival . The role of ArgJ is to recycle an acetyl moiety by catalytically transferring this group from N -acetylornithine to the l -glutamate starting material. , In 2018, Mishra and co-workers reported the first inhibitors of Mtb ArgJ .…”
Section: Preclinical Promisesmentioning
confidence: 99%
See 1 more Smart Citation
“…Ornithine acetyltransferase (ArgJ) is one of eight essential enzymes within the l -arginine biosynthesis pathway, which is critical for Mtb survival . The role of ArgJ is to recycle an acetyl moiety by catalytically transferring this group from N -acetylornithine to the l -glutamate starting material. , In 2018, Mishra and co-workers reported the first inhibitors of Mtb ArgJ .…”
Section: Preclinical Promisesmentioning
confidence: 99%
“…Ornithine acetyltransferase (ArgJ) is one of eight essential enzymes within the l -arginine biosynthesis pathway, which is critical for Mtb survival . The role of ArgJ is to recycle an acetyl moiety by catalytically transferring this group from N -acetylornithine to the l -glutamate starting material. , In 2018, Mishra and co-workers reported the first inhibitors of Mtb ArgJ . Pranlukast ( 88 ) (Figure ), an asthma medication having widespread use in Japan, was identified as the best hit from a library of approved drugs, following in silico screening and assessment in enzyme assays.…”
Section: Preclinical Promisesmentioning
confidence: 99%
“…aerA is the encoding gene of aerolysin, which is a kind of Aeromonas chief toxin [ 19 ]. argF is a key member of the arginine biosynthesis pathway, while the argF deletion mutant of Mycobacterium tuberculosis is rapidly sterilized in mice [ 83 ]. dhaL is associated with glycerol metabolism, which contributes to the cell fitness and virulence of Actinotignum schaalii [ 84 ] and Listeria monocytogenes [ 85 ].…”
Section: Discussionmentioning
confidence: 99%
“…Thus, mutants of argF encoding ornithine carbamoyltransferase exhibit decreased pathogenicity and survival of Mtb in immunocompetent and immunocompromised mice [ 6 ]. Recently, argB mutants have shown decreased survival of Mtb by inducing oxidative stress [ 7 , 8 ]. While all the enzymes of the arginine pathway have been proposed to be essential for Mtb growth, among them argJ has been considered as a promising target for drug discovery and development against Mtb survival due to the lack of a homolog in humans [ 7 , 8 ].…”
Section: Introductionmentioning
confidence: 99%
“…Recently, argB mutants have shown decreased survival of Mtb by inducing oxidative stress [ 7 , 8 ]. While all the enzymes of the arginine pathway have been proposed to be essential for Mtb growth, among them argJ has been considered as a promising target for drug discovery and development against Mtb survival due to the lack of a homolog in humans [ 7 , 8 ]. The gene argJ encodes for the monofunctional enzyme ornithine acetyltransferase in Mtb , which acts on the substrates of first and fifth reactions in the arginine biosynthetic pathway [ 9 ].…”
Section: Introductionmentioning
confidence: 99%