A frame shift due to a two‐nucleotide insertion results in an HLA‐DRB1 null allele, DRB1*1517N

Lebedeva, Tatiana; Ohashi, M.; Huang, A.; Zannelli, Georgia; Yu, Neng

doi:10.1111/j.1399-0039.2005.00472c.x

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Hla High‐resolution Typing Results: Statistics 2009a1

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Cited by 6 publications

(2 citation statements)

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“…So far, only a few DRB1 null alleles have been reported (DRB1*1517N, DRB1*0710N, DRB1‐14N and DRB1*1613N) (1–4). The mutations that prevent the expression of these null alleles include nucleotide insertions or deletions and, as seen in the allele described here, a nucleotide substitution.…”

mentioning

confidence: 70%

DRB1*1613N: a novel DRB1 allele with a premature termination codon

Zhao¹,

Guerrero²,

Kerman³

et al. 2007

Tissue Antigens

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mentioning

confidence: 70%

DRB1*1613N: a novel DRB1 allele with a premature termination codon

Zhao¹,

Guerrero²,

Kerman³

et al. 2007

Tissue Antigens

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“…Compared with HLA‐A and ‐B, only a few DRB1 null mutants have been identified so far (4–7): 66 HLA‐A null variants, 57 HLA‐B and 6 HLA‐DRB1, including the DRB1*12:24N (IMGT/HLA database v 3.1 released July 2010). The length of the variable region of the DBR1 gene is smaller (exon 2: 270 bp) than that of the class I genes (exon 2 + 3: 546 bp).…”

Section: Hla High‐resolution Typing Results: Statistics 2009amentioning

confidence: 99%

Eight new alleles found in Flanders (Belgium), including the HLA‐DRB112:24N* allele

Sandt¹,

Mahieu²,

Emonds³

2011

Tissue Antigens

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Human leukocyte antigen (HLA) high-resolution matching is routinely performed in the case of hematopoietic stem cell transplantation. Misdiagnosis of rare or new variants will result in additional unknown mismatches that can trigger graft versus host disease and/or graft failure. Using a mono allelic sequencing strategy, we obtained >90% first-step sequence-based high-resolution typing results, conforming to the standards set down by the European Federation for Immunogenetics. During this routine analysis, eight new HLA alleles were identified, including one DRB1*12 null variant, DRB1*12:24N and three other coding mutants, resulting in a change of properties of the corresponding antigens.

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Nomenclature for Factors of the HLA System, Update November 2005

Marsh¹

2005

Human Immunology

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A frame shift due to a two‐nucleotide insertion results in an HLA‐DRB1 null allele, DRB1*1517N

Cited by 6 publications

References 5 publications

DRB1*1613N: a novel DRB1 allele with a premature termination codon

DRB1*1613N: a novel DRB1 allele with a premature termination codon

Eight new alleles found in Flanders (Belgium), including the HLA‐DRB112:24N* allele

Nomenclature for Factors of the HLA System, Update November 2005

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A frame shift due to a two‐nucleotide insertion results in an HLA‐DRB1 null allele, DRB1*1517N

Cited by 6 publications

References 5 publications

DRB1*1613N: a novel DRB1 allele with a premature termination codon

DRB1*1613N: a novel DRB1 allele with a premature termination codon

Eight new alleles found in Flanders (Belgium), including the HLA‐DRB1*12:24N allele

Nomenclature for Factors of the HLA System, Update November 2005

Contact Info

Product

Resources

About

Eight new alleles found in Flanders (Belgium), including the HLA‐DRB112:24N* allele