A framework and resource for global collaboration in non-human primate neuroscience

Hartig, Renée; Klink, P. Christiaan; Polyakova, Zlata; Dehaqani, Mohammad-Reza A.; Bondar, I. V.; Merchant, Hugo; Vanduffel, Wim; Roe, Anna Wang; Nambu, Atsushi; Thirumala, M.; Shmuel, Amir; Kapoor, Vishal; Gothard, Katalin M.; Evrard, H; Basso, Michele A.; Petkov, Christopher I.; Mitchell, Anna S.

doi:10.1016/j.crneur.2023.100079

Cited by 4 publications

(2 citation statements)

References 66 publications

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“…Mid-size animals such as rabbits, cats, and dogs have more complex brain functions than rodents and may be used for specialized testing such as sleep studies for cats or studies on the heart for dogs ( Pinnapureddy et al, 2015 ; Sánchez-León et al, 2018 ), whereas rabbits have been used extensively in peripheral nerve injury and repair studies ( Kim et al, 2020 ; Koppaka et al, 2022 ; Sorkin et al, 2022 ). Non-human primates (NHP), with complex brain functions most similar to humans, offer advantages for brain imaging studies, however are costly and may be difficult to procure ( Milham et al, 2020 ; Song et al, 2021 ; Hartig et al, 2023 ; Suminski et al, 2023 ). Additionally, most NHP are small, with rhesus macaques weighing 8–12 kg, and the largest research NHPs, baboons, weighing ~16 kg ( Nakamura et al, 2021 ; Song et al, 2021 ).…”

Section: Preclinical Studies ( K L Vincent )mentioning

confidence: 99%

Bioelectronic Medicine: a multidisciplinary roadmap from biophysics to precision therapies

González-González,

Conde,

Latorre

et al. 2024

Front. Integr. Neurosci.

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Bioelectronic Medicine stands as an emerging field that rapidly evolves and offers distinctive clinical benefits, alongside unique challenges. It consists of the modulation of the nervous system by precise delivery of electrical current for the treatment of clinical conditions, such as post-stroke movement recovery or drug-resistant disorders. The unquestionable clinical impact of Bioelectronic Medicine is underscored by the successful translation to humans in the last decades, and the long list of preclinical studies. Given the emergency of accelerating the progress in new neuromodulation treatments (i.e., drug-resistant hypertension, autoimmune and degenerative diseases), collaboration between multiple fields is imperative. This work intends to foster multidisciplinary work and bring together different fields to provide the fundamental basis underlying Bioelectronic Medicine. In this review we will go from the biophysics of the cell membrane, which we consider the inner core of neuromodulation, to patient care. We will discuss the recently discovered mechanism of neurotransmission switching and how it will impact neuromodulation design, and we will provide an update on neuronal and glial basis in health and disease. The advances in biomedical technology have facilitated the collection of large amounts of data, thereby introducing new challenges in data analysis. We will discuss the current approaches and challenges in high throughput data analysis, encompassing big data, networks, artificial intelligence, and internet of things. Emphasis will be placed on understanding the electrochemical properties of neural interfaces, along with the integration of biocompatible and reliable materials and compliance with biomedical regulations for translational applications. Preclinical validation is foundational to the translational process, and we will discuss the critical aspects of such animal studies. Finally, we will focus on the patient point-of-care and challenges in neuromodulation as the ultimate goal of bioelectronic medicine. This review is a call to scientists from different fields to work together with a common endeavor: accelerate the decoding and modulation of the nervous system in a new era of therapeutic possibilities.

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Section: Preclinical Studies ( K L Vincent )mentioning

confidence: 99%

Bioelectronic Medicine: a multidisciplinary roadmap from biophysics to precision therapies

González-González,

Conde,

Latorre

et al. 2024

Front. Integr. Neurosci.

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“…Detailed information about human participants, EEG data collection, and analysis procedures can be found in a recent study (Criscuolo, Schwartze, Henry, et al, 2022). Briefly, we randomly selected 4 human participants from a dataset of 20 (Hartig et al, 2023).…”

Section: Methodsmentioning

confidence: 99%

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Criscuolo

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Introducing individual sentience profiles in nonhuman primate neuroscience research

Kaufmann

2023

Current Research in Neurobiology

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A framework and resource for global collaboration in non-human primate neuroscience

Cited by 4 publications

References 66 publications

Bioelectronic Medicine: a multidisciplinary roadmap from biophysics to precision therapies

Bioelectronic Medicine: a multidisciplinary roadmap from biophysics to precision therapies

Ordo ab chaos

Introducing individual sentience profiles in nonhuman primate neuroscience research

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