The current study aimed to evaluate the influence of seawater intrusion into groundwater and potential irrigation hazards in the coastal region of Tamil Nadu, India, by analyzing 177 groundwater samples. According to GQISWI, the data shows that 72% of the groundwater samples were contaminated by seawater mixing. Furthermore, seawater mixing into freshwater is evident in 65.5% of the groundwater samples, with a seawater mixing index value greater than 1. According to the USSL classification of electric conductivity for irrigation water quality, 36.7% of samples are classified as very high (>2251 µS/cm), 44% as high (751- 2250 µS/cm), 15.3% as medium (251-750 µS/cm), and 3.4% as low (<250 µS/cm) salinity hazards. Further, the potential salinity reveals that 75% of the samples have high salinity problems while 25% of the samples are moderately suitable for irrigation. According to the statistical analysis, there is a significant correlation between EC and Ca2+ (r=0.93), Mg2+ (r=0.94), Na+ (r=0.92), Cl- (r=0.99), and NO3- (r=0.19), indicating that human activities have a considerable impact on giving these ions to groundwater in the study region. In addition, overexploitation of groundwater through deep borewells for agriculture and domestic purposes, as well as climate change, may result in salinization of coastal aquifers in the study area.