A framework for designing delivery systems

Poon, Wilson; Kingston, Benjamin R.; Ouyang, Ben; Ngo, Wayne; Chan, Warren C. W.

doi:10.1038/s41565-020-0759-5

Cited by 388 publications

(298 citation statements)

References 112 publications

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“…In particular, the relatively insufficient targeting and accumulation of nanoparticles in the tumor present a major limitation for nanomedicine translation, which may be overcome by analyzing the nanoparticle‐biological interactions and further optimizing the delivery systems. [ 127 ] Besides, more studies about the systemic toxicity and optimal dosing of nanoparticles are required.…”

Section: Conclusion and Future Outlookmentioning

confidence: 99%

Macrophage‐Mediated Tumor Cell Phagocytosis: Opportunity for Nanomedicine Intervention

Zhou

Liu

Huang

2020

Adv Funct Materials

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Macrophages are one of the most abundant non‐malignant cells in the tumor microenvironment, playing critical roles in mediating tumor immunity. As important innate immune cells, macrophages possess the potential to engulf tumor cells and present tumor‐specific antigens for adaptive antitumor immunity induction, leading to growing interest in targeting macrophage phagocytosis for cancer immunotherapy. Nevertheless, live tumor cells have evolved to evade phagocytosis by macrophages via the extensive expression of anti‐phagocytic molecules, such as CD47. In addition, macrophages also rapidly recognize and engulf apoptotic cells (efferocytosis) in the tumor microenvironment, which inhibits inflammatory responses and facilitates immune escape of tumor cells. Thus, intervention of macrophage phagocytosis by blocking anti‐phagocytic signals on live tumor cells or inhibiting tumor efferocytosis presents a promising strategy for the development of cancer immunotherapies. Here, the regulation of macrophage‐mediated tumor cell phagocytosis is first summarized, followed by an overview of strategies targeting macrophage phagocytosis for the development of antitumor therapies. Given the potential off‐target effects associated with the administration of traditional therapeutics (for example, monoclonal antibodies and small molecule inhibitors), the opportunity for nanomedicine in macrophage phagocytosis intervention is highlighted.

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Section: Conclusion and Future Outlookmentioning

confidence: 99%

Macrophage‐Mediated Tumor Cell Phagocytosis: Opportunity for Nanomedicine Intervention

Zhou

Liu

Huang

2020

Adv Funct Materials

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“…Similarly, this model can also be used to predict more sequential and complexed anticancer delivery progress, such as the incorporation of intracellular trafficking and responsive release, with the addition of corresponding parameters. Moreover, our prediction function formula may be incorporated with the specific parameters that represented the patient-specific microenvironments for guiding nanocarrier optimal design and further personalized therapy ( 39 ).…”

Section: Discussionmentioning

confidence: 99%

Experimental and theoretical explorations of nanocarriers’ multistep delivery performance for rational design and anticancer prediction

et al. 2021

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The poor understanding of the complex multistep process taken by nanocarriers during the delivery process limits the delivery efficiencies and further hinders the translation of these systems into medicine. Here, we describe a series of six self-assembled nanocarrier types with systematically altered physical properties including size, shape, and rigidity, as well as both in vitro and in vivo analyses of their performance in blood circulation, tumor penetration, cancer cell uptake, and anticancer efficacy. We also developed both data and simulation-based models for understanding the influence of physical properties, both individually and considered together, on each delivery step and overall delivery process. Thus, beyond finding that nanocarriers that are simultaneously endowed with tubular shape, short length, and low rigidity outperformed the other types, we now have a suit of theoretical models that can predict how nanocarrier properties will individually and collectively perform in the multistep delivery of anticancer therapies.

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“…Introducing small biomolecules, nucleic acids (DNA and RNA), proteins, synthetic nanomaterials, and drugs into cells (coined as intracellular delivery) is a powerful means to monitor and decode the cellular behaviors as well as influence the cellular fates and its biological functions. [ 1 ] Efficient intracellular delivery technologies play a crucial role in biomedical discoveries, biomanufacture, and therapeutic applications. [ 2 ] Direct delivery of exogenous cargoes requires to surpass the plasma membrane barrier, which protects the intracellular compositions from outside of the cell.…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Review on Intracellular Delivery

Rad

Bazaz

et al. 2021

Advanced Materials

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Intracellular delivery is considered an indispensable process for various studies, ranging from medical applications (cell‐based therapy) to fundamental (genome‐editing) and industrial (biomanufacture) approaches. Conventional macroscale delivery systems critically suffer from such issues as low cell viability, cytotoxicity, and inconsistent material delivery, which have opened up an interest in the development of more efficient intracellular delivery systems. In line with the advances in microfluidics and nanotechnology, intracellular delivery based on micro‐ and nanoengineered platforms has progressed rapidly and held great promises owing to their unique features. These approaches have been advanced to introduce a smorgasbord of diverse cargoes into various cell types with the maximum efficiency and the highest precision. This review differentiates macro‐, micro‐, and nanoengineered approaches for intracellular delivery. The macroengineered delivery platforms are first summarized and then each method is categorized based on whether it employs a carrier‐ or membrane‐disruption‐mediated mechanism to load cargoes inside the cells. Second, particular emphasis is placed on the micro‐ and nanoengineered advances in the delivery of biomolecules inside the cells. Furthermore, the applications and challenges of the established and emerging delivery approaches are summarized. The topic is concluded by evaluating the future perspective of intracellular delivery toward the micro‐ and nanoengineered approaches.

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A framework for designing delivery systems

Cited by 388 publications

References 112 publications

Macrophage‐Mediated Tumor Cell Phagocytosis: Opportunity for Nanomedicine Intervention

Macrophage‐Mediated Tumor Cell Phagocytosis: Opportunity for Nanomedicine Intervention

Experimental and theoretical explorations of nanocarriers’ multistep delivery performance for rational design and anticancer prediction

A Comprehensive Review on Intracellular Delivery

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